Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium

Endocrinology

Volumn 150, Issue 2, 2009, Pages 561-569

  Cao, Guofan ^a   Gu, Zhen ^a   Ren, Yongxin ^a   Shu, Lei ^a   Tao, Chunxiang ^a   Karaplis, Andrew ^b   Goltzman, David ^b   Miao, Dengshun ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CALCIUM; PARATHYROID HORMONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DENSITY; BONE TURNOVER; BREAST MILK; CONTROLLED STUDY; DIET; FEMALE; HORMONE BLOOD LEVEL; LACTATION; MALE; MOUSE; NEWBORN PERIOD; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; ANIMALS, SUCKLING; BONE DENSITY; CALCIUM; CHOLECALCIFEROL; DRUG SYNERGISM; EATING; FEMALE; GROWTH; LACTATION; MALE; MICE; MICE, TRANSGENIC; MILK; OSTEOBLASTS; OSTEOGENESIS; PARATHYROID HORMONE; PARATHYROID HORMONE-RELATED PROTEIN;

EID: 59649096889     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0654     Document Type: Article

References (50)

1. Juppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski Jr LF, Hock J, Potts Jr JT, Kronenberg HM, Segre GV 1991 A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024-1026
2. Reeve J 1996 PTH: a future role in the management of osteoporosis? J Bone Miner Res 11:440-445
3. Hodsman AB, Fraher LJ, Watson PH, Ostbye T, Stitt LW, Adachi JD, Taves DH, Drost D 1997 A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 82:620-628
4. Orwoll ES, Scheele WH, Paul S, Adami S, Syversen U, Diez-Perez A, Kaufman JM, Clancy AD, Gaich GA 2003 The effect of teriparatide [human parathyroid hormone (1-34)] therapy on bone density in men with osteoporosis. J Bone Miner Res 18:9-17
5. Girotra M, Rubin MR, Bilezikian JP 2006 Anabolic skeletal therapy for osteoporosis. Arq Bras Endocrinol Metabol 50:745-754
6. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH 2001 Effectofparathyroidhormone(1-34)onfracturesandbonemineraldensity in postmenopausal women with osteoporosis. N Engl J Med 344:1434-1441
7. Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL 2003 Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem 278:50259-50272
8. Zaidi M 2007 Skeletal remodeling in health and disease. Nat Med 13:791-801
9. Miao D, He B, Karaplis AC, Goltzman D 2002 Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 109:1173-1182
10. Xue Y, Karaplis AC, Hendy GN, Goltzman D, Miao D 2005 Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development. Hum Mol Genet 14:1515-1528
11. Chan FK,Tiu SC,Choi KL,Choi CH, Kong AP,Shek CC 2003 Increased bone mineral density in patients with chronic hypoparathyroidism. J Clin Endocrinol Metab 88:3155-3159
12. Miao D,HeB,Lanske B,Bai XY,Tong XK,Hendy GN,Goltzman D,Karaplis AC 2004 Skeletal abnormalities in Pth-null mice are influenced by dietary calcium. Endocrinology 145:2046 -2053
13. FlynnA2003Theroleofdietarycalciuminbonehealth.ProcNutrSoc62: 851-858
14. Aloia JF, Vaswani A, Yeh JK, Ross PL, Flaster E,Dilmanian FA1994 Calcium supplementation with and without hormone replacement therapy to prevent postmenopausal bone loss. Ann Intern Med 120:97-103
15. Fujita T, Ohue T, Fujii Y, Miyauchi A, Takagi Y 1995 Effect of calcium supplementation on bone density and parathyroid function in elderly subjects. Miner Electrolyte Metab 21:229-231
16. Thomas M, Weisman SM 2006 Calcium supplementation during pregnancy and lactation: effects on the mother and the fetus. Am J Obstet Gynecol 194:937-945
17. Kalkwarf HJ, Specker BL, Bianchi DC, Ranz J, Ho M 1997 The effect of calcium supplementation on bone density during lactation and after weaning. N Engl J Med 337:523-528
18. Heaney RP2001 Calcium needs of the elderly to reduce fracture risk. J Am Coll Nutr 20(Suppl):192S-197S
19. Lewiecki EM 2008 Prevention and treatment of postmenopausal osteoporosis. Obstet Gynecol Clin North Am 35:301-315
20. Prince RL, Devine A, Dhaliwal SS, Dick IM 2006 Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med 166:869-875
21. Shea B, Wells G, Cranney A, Zytaruk N, Robinson V, Griffith L, Hamel C, Ortiz Z, Peterson J, Adachi J, Tugwell P, Guyatt G 2004 Calcium supplementation on bone loss in postmenopausal women. Cochrane Database Syst Rev CD004526
22. VanHouten J, Dann P, McGeoch G, Brown EM, Krapcho K, Neville M, Wysolmerski JJ 2004 The calcium-sensing receptor regulates mammary gland parathyroid hormone-related proteinproduction and calciumtransport. J Clin Invest 113:598-608
23. Xue Y, Zhang Z, Karaplis AC, Hendy GN, Goltzman D, Miao D 2005 Exogenous PTH-related protein and PTH improve mineral and skeletal status in 25-hydroxyvitamin D-1α-hydroxylase and PTH double knockout mice. J Bone Miner Res 20:1766-1777
24. Xue Y, Karaplis AC, Hendy GN, Goltzman D, Miao D 2006 Exogenous 1,25-dihydroxyvitamin D3 exerts a skeletal anabolic effect and improves mineral ion homeostasis in mice that are homozygous for both the 1 α-hydroxylase and parathyroid hormone null alleles. Endocrinology 147:4801-4810
25. Miao D,Bai X,Panda D,McKee M,Karaplis A,Goltzman D2001 Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition. Endocrinology 142:926 -939
26. 3 response to short-term treatment with 1,25-dihy-droxyvitamin D3 in vivo. BMC Musculoskelet Disord 3:16
27. Ardeshirpour L, Dann P, Pollak M, Wysolmerski J, VanHouten J 2006 The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland. Bone 38:787-793
28. Van Houten JN, Neville MC, Wysolmerski JJ 2007 The calcium-sensing re-ceptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk. Endocrinology 148:5943-5954
29. Townsend K, Banwell CM, Guy M, Colston KW, Mansi JL, Stewart PM, Campbell MJ, Hewison M 2005 Autocrine metabolism of vitamin D in normal and malignant breast tissue. Clin Cancer Res 11:3579-3586
30. Basile LA, Taylor SN, Wagner CL, Horst RL, Hollis BW2006 The effect of high-dose vitamin D supplementation on serum vitamin D levels and milk calcium concentration in lactating women and their infants. Breastfeed Med 1:27-35
31. Jarjou LM, Prentice A, Sawo Y, Laskey MA, Bennett J, Goldberg GR, Cole TJ 2006 Randomized, placebo-controlled, calcium supplementation study in pregnant Gambian women: effects on breast-milk calcium concentrations and infant birth weight, growth, and bone mineral accretion in the first year of life. Am J Clin Nutr 83:657-666
32. Caplan RH, Wickus GG, Sloane K, Silva PD 1995 Serum parathyroid hormone-related protein levels during lactation. J Reprod Med 40:216 -218
33. Lippuner K, Zehnder HJ, Casez JP, Takkinen R, Jaeger P 1996 PTH-related protein is released into the mother's bloodstream during location: evidence for beneficial effects on maternal calcium-phosphate metabolism. J Bone Miner Res 11:1394-1399
34. Sowers MF, Hollis BW, Shapiro B, Randolph J, Janney CA, Zhang D, Schork A, Crutchfield M, Stanczyk F, Russell-Aulet M 1996 Elevated parathyroid hormone-related peptide associated with lactation and bone density loss. JAMA 276:549-554
35. Kovacs CS, Fuleihan Gel H 2006 Calcium and bone disorders during pregnancy and lactation. Endocrinol Metab Clin North Am 35:21-51
36. Kovacs CS, Kronenberg HM 1997 Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocr Rev 18:832-872
37. Horst RL, Goff JP, Reinhardt TA 2005 Adapting to the transition between gestation and lactation: differences between rat,human anddairycow. JMammary Gland Biol Neoplasia 10:141-156
38. Hodnett DW, DeLuca HF,Jorgensen NA1992Boneminerallossduringlactation occurs in absence of parathyroid tissue. Am J Physiol 262(2 Pt1):E230-E233
39. Hollis BW, Roos BA, Draper HH, Lambert PW 1981 Vitamin D and its metabolites in human and bovine milk. J Nutr 111:1240 -1248
40. Panda DK,Miao D,Tremblay ML,Sirois J,Farookhi R,Hendy GN,Goltzman D 2001 Targeted ablation of the 25-hydroxyvitamin D 1α-hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci USA 98:7498-7503
41. Mentaverri R, Yano S, Chattopadhyay N, Petit L, Kifor O, Kamel S, Terwilliger EF, Brazier M, Brown EM2006 The calcium sensing receptor is directlyinvolved in both osteoclast differentiation and apoptosis. FASEB J 20:2562-2564
42. 2+-sensing receptor promotes loss of cancellous bone. Endocrinology 148:3156-3163
43. Dvorak MM,Tu C,Elalieh H, Chen T, Liu B, Kream BE, Bikle DD,ChangW, Shoback DM 2007 Conditional ablation of the osteoblast calcium-sensing receptor causes abnormalities in skeletal development and mineralization. J Bone Miner Res 22(Suppl 1):M223
44. Chang W,Tu C,ChenTH, Bikle D, Shoback D 2008 The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal 1:ra1
45. GodwinSL,Soltoff SP1997 Extracellular calcium and platelet-derived growth factor promote receptor-mediated chemotaxis in osteoblasts through different signaling pathways. J Biol Chem 272:11307-11312
46. Yamaguchi T, Chattopadhyay N, Kifor O, Butters Jr RR, Sugimoto T, Brown EM 1998 Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca2 + o)-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells. J Bone Miner Res 13:1530-1538
47. Dvorak MM, Siddiqua A, Ward DT, Carter DH, Dallas SL, Nemeth EF, Riccardi D 2004 Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones. Proc Natl Acad Sci USA 101:5140-5145
48. Eklou-Kalonji E, Denis I, Lieberherr M, Pointillart A 1998 Effects of extracellular calcium on the proliferation and differentiation of porcine osteoblasts in vitro. Cell Tissue Res 292:163-171
49. Nakade O, Takahashi K, Takuma T, Aoki T, Kaku T2001 Effect of extracellular calcium on the gene expression of bone morphogenetic protein-2 and -4 of normal human bone cells. J Bone Miner Metab 19:13-19
50. Woodrow JP, Sharpe CJ, Fudge NJ, Hoff AO, Gagel RF, Kovacs CS 2006 Calcitonin plays a critical role in regulating skeletal mineral metabolism during lactation. Endocrinology 147:4010-4021