Trichothecenes in cereal grains

International Journal of Molecular Sciences

Volumn 10, Issue 1, 2009, Pages 147-173

  Foroud, Nora A ^a,b   Eudes, Francois ^a  

^a LETHBRIDGE RESEARCH CENTRE   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cereal grain; Fusarium head blight; Trichothecene

Indexed keywords

BUTENOLIDE; FUMONISIN; HT 2 TOXIN; MONILIFORMIN; NIVALENOL; T 2 TOXIN; TRICHOTHECENE DERIVATIVE; VOMITOXIN; ZEARALENONE;

CEREAL; FOOD CONTAMINATION; FOOD QUALITY; FOOD SAFETY; FUSARIUM; FUSARIUM HEAD BLIGHT; GRAIN; INFECTION RESISTANCE; MYCOTOXICOSIS; NONHUMAN; PHYTOTOXICITY; PLANT BREEDING; REVIEW; SCREENING; TOXIN ANALYSIS; TOXIN STRUCTURE; TOXIN SYNTHESIS;

CEREAL GRAIN; FUSARIUM HEAD BLIGHT; TRICHOTHECENE;

CEREALS; DISEASE RESISTANCE; FUSARIUM; PLANT DISEASES; TRICHOTHECENES;

FUSARIUM;

EID: 59649092613     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms10010147     Document Type: Review

References (175)

1. Parry, D.W.; Jenkinson, P.; McLeod, L. Fusarium ear blight (scab) in small grain cereals-a review. Plant Pathol. 1995, 44, 207-238.
2. Tóth, B.; Mesterházy, Á.; Horvath, Z.; Bartók, T.; Varga, M.; Varga, J. Genetic Variability of Central European Isolates of the Fusarium graminearum Species Complex. Eur. J. Plant Pathol. 2005, 113, 35-45.
3. Eudes, F.; Comeau, A.; Rioux, S.; Collin, J. Impact of trichothecenes on fusarium head blight (Fusarium graminearum) development in spring wheat (Triticum aestivum). Can. J. Plant Pathol. 2001, 23, 318-322.
4. Harris, L.J.; Desjardins, A.E.; Plattner, R.D.; Nicholson, P.; Butler, G.; Young, Y.C.; Weston, G.; Proctor, R.H.; Hohn, T.M. Possible role of trichothecene mycotoxins in virulence of Fusarium graminearum on maize. Plant Dis. 1999, 83, 954-960.
5. Langevin, F.; Eudes, F.; Comeau, A. Effect of trichothecenes produced by Fusarium graminearum during fusarium head blight development in six cereal species. Eur. J. Plant Pathol. 2004, 110, 735-746.
6. Proctor, R.H.; Hohn, T.M.; McCormick, S.P. Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene. Mol. Plant-Microbe Interact. 1995, 8, 593-601.
7. Eriksen, G.S.; Pettersson, H. Toxicological evaluation of trichothecenes in animal feed. Anim. Feed Sci. Technol. 2004, 114, 205-239.
8. Stack, R.W. History of fusarium head blight with emphasis on North America. In Fusarium Head Blight of Wheat and Barley; Leonard, K.J., Bushnell, W.R., Eds.; The American Phytopathological Society: St. Paul, Minnesota, USA, 2003; Chapter 1, pp. 1-34.
9. Gilbert, J.; Tekauz, A. Review: Recent developments in research on fusarium head blight of wheat in Canada. Can. J. Plant Pathol. 2000, 22, 1-8.
10. Moschini, R.C.; Fortugno, C. Predicting wheat head blight incidence using models based on meteorological factors in Pergamino, Argentina. Eur. J. Plant Pathol. 1996, 102, 211-218.
11. McMullen, M. Impacts of fusarium head blight on North American agricultural community: The power of one disease to catapult change. In Fusarium Head Blight of Wheat and Barley; Leonard, K.J., Bushnell, W.R., Eds.; The American Phytopathological Society: St. Paul, Minnesota, USA, 2003; Chapter 18, pp. 484-503.
12. Bai, G.-H.; Chen, L.-F.; Shaner, G.E. Breeding for resistance to fusarium head blight of wheat in China. In Fusarium Head Blight of Wheat and Barley; Leonard, K.J., Bushnell, W.R., Eds.; The American Phytopathological Society: St. Paul, Minnesota, USA, 2003; Chapter 11, pp. 296-317.
13. Bhat, R.V.; Beedu, S.R.; Ramakrishna, Y.; Munshi, K.L. Outbreak of Trichothecene mycotoxicosis associated with consumption of mold-damaged wheat products in Kashmir Valley India. Lancet 1989, 1, 35-37.
14. Burgess, L.W.; Klein, T.A.; Bryden, W.L.; Tobin, N.F. Head Blight of Wheat Caused by Fusarium graminearum Group 1 in New South Wales Australia in 1983. Australas. Plant Pathol. 1987, 16, 72-78.
15. Xu, X.M.; Nicholson, P.; Thomsett, M.A.; Simpson, D.; Cooke, B.M.; Doohan, F.M.; Brennan, J.; Monaghan, S.; Moretti, A.; Mule, G.; Homok, L.; Beki, E.; Tatnell, J.; Ritieni, A.; Edwards, S.G. Relationship between the fungal complex causing fusarium head blight of wheat and environmental conditions. Phytopathology 2008, 98, 69-78.
16. Kriel, W.M.; Pretorius, Z.A. The FHB challenge to irrigation wheat production in South Africa. Cereal Res. Commun. 2008, 36, 569-571.
17. Scott, D.B.; De Jager, E.J.H.; Van Wyk, P.S. Head blight of irrigated wheat in South Africa. Phytophylactica 1988, 20, 317-319.
18. McMullen, M.; Jones, R.; Gallenberg, D. Scab of wheat and barley: A re-emerging disease of devasting impact. Plant Dis. 1997, 81, 1340-1348.
19. Xu, X. Effects of environmental conditions on the development of Fusarium ear blight. Eur. J. Plant Pathol. 2003, 109, 683-689.
20. Hongxiang, M.; Yao, J.; Zhou, M.; Zhang, X.; Ren, L.; Yu, G.; Lu, W. Molecular breeding for wheat fusarium head blight resistance in China. Cereal Res. Commun. 2008, 36, 1-730.
21. Dill-Macky, R.; Jones, R.K. The effect of previous crop residues and tillage on fusarium head blight of wheat. Plant Dis. 2000, 84, 71-76.
22. Gilbert, J.; Fernando, W.G.D. Epidemiology and biological control of Gibberella zeae Fusarium graminearum. Can. J. Plant Pathol. 2004, 26, 464-472.
23. Horsley, R.D.; Pederson, J.D.; Schwarz, P.B.; McKay, K.; Hochhalter, M.R.; McMullen, M.P. Integrated use of tebuconazole and fusarium head blight-resistant barley genotypes. Agron. J. 2006, 98, 194-197.
24. Jones, R.K. Assessments of fusarium head blight of wheat and barley in response to fungicide treatment. Plant Dis. 2000, 84, 1021-1030.
25. Khan, M.R.; Fischer, S.; Egan, D.; Doohan, F.M. Biological control of Fusarium seedling blight disease of wheat and barley. Phytopathology 2006, 96, 386-394.
26. Miller, J.D.; Culley, J.; Fraser, K.; Hubbard, S.; Meloche, F.; Ouellet, T.; Seaman, W.L.; Seifert, K.A.; Turkington, K.; Voldeng, H. Effect of tillage practice on fusarium head blight of wheat. Can. J. Plant Pathol. 1998, 20, 95-103.
27. Paul, P.A.; Lipps, P.E.; Hershman, D.E.; McMullen, M.P.; Draper, M.A.; Madden, L.V. A Quantitative review of tebuconazole effect on fusarium head blight and deoxynivalenol content in wheat. Phytopathology 2007, 97, 211-220.
28. De Wolf, E.D.; Madden, L.V.; Lipps, P.E. Risk assessment models for wheat fusarium head blight epidemics based on within-season weather data. Phytopathology 2003, 93, 428-435.
29. Prandini, A.; Sigolo, S.; Filippi, L.; Battilani, P.; Piva, G. Review of predictive models for fusarium head blight and related mycotoxin contamination in wheat. Food Chem. Toxicol. 2008, [epub].
30. McMullen, M.; Halley, S.; Schatz, B.; Meyer, S.; Jordahl, J.; Ransom, J. Integrated strategies for fusarium head blight management in the United States. Cereal Res. Commun. 2008, 36, 563-568.
31. Miedaner, T.; Reinbrecht, C.; Lauber, U.; Schollenberger, M.; Geiger, H.H. Effects of genotype and genotype-environment interaction on deoxynivalenol accumulation and resistance to fusarium head blight in rye, triticale, and wheat. Plant Breed. 2001, 120, 97-105.
32. Foroud, N.; MacMillan, T.; Ellis, B.; Eudes, F. The role of trichothecene-chemotypes in fusarium head blight disease spread in wheat. Cereal Res. Commun. 2008, 36, 489-490.
33. Mesterhazy, Á. Role of deoxynivalenol in aggressiveness of Fusarium graminearum and F. culmorum and in resistance to fusarium head blight. Eur. J. Plant Pathol. 2002, 108, 675-684.
34. Desjardins, A.E.; Hohn, T.M.; McCormick, S.P. Trichothecene biosynthesis in Fusarium species: Chemistry, genetics, and significance. Microbiol. Rev. 1993, 57, 595-604.
35. Mirocha, C.J.; Xie, W.; Filho, E.R. Chemistry and detection of Fusarium mycotoxins. In Fusarium Head Blight of Wheat and Barley; Leonard, K.J., Bushnell, W.R., Eds.; The American Phytopathological Society: St. Paul, Minnesota, USA, 2003; Chapter 6, pp. 144-164.
36. Liddell, C.M. Systematics of Fusarium species and allies associated with fusarium head blight. In Fusarium Head Blight of Wheat and Barley; Leonard, K.J., Bushnell, W.R., Eds.; The American Phytopathological Society: St. Paul, Minnesota, USA, 2003; Chapter 2, pp. 35-43.
37. Ueno, Y. Trichothecenes: Chemical, Biological and Toxicological Aspects. Elsevier Scientific Publishers: Amsterdam, 1983.
38. Sudakin, D.L. Trichothecenes in the environment: Relevance to human health. Toxicol. Lett. 2003, 143, 97-107.
39. Desjardins, A.E.; Proctor, R.H. Molecular biology of Fusarium mycotoxins. Int. J. Food Microbiol. 2007, 119, 47-50.
40. Harris, L.J.; Alexander, N.J.; Saparno, A.; Blackwell, B.; McCormick, S.P.; Desjardins, A.E.; Robert, L.S.; Tinker, N.; Hattori, J.; Piche, C.; Schernthaner, J.P.; Watson, R.; Ouellet, T. A novel gene cluster in Fusarium graminearum contains a gene that contributes to butenolide synthesis. Fungal Genet. Biol. 2007, 44, 293-306.
41. Hohn, T.M.; Vanmiddlesworth, F. Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides. Arch. Biochem. Biophys. 1986, 251, 756-761.
42. Hohn, T.M.; Desjardins, A.E.; McCormick, S.P. The Tri4 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase involved in trichothecene biosynthesis. Mol. Gen. Genet. 1995, 248, 95-102.
43. McCormick, S.P.; Alexander, N.J.; Proctor, R.H. Fusarium Tri4 encodes a multifunctional oxygenase required for trichothecene biosynthesis. Can. J. Microbiol. 2006, 52, 636-642.
44. McCormick, S.P.; Taylor, S.L.; Plattner, R.D.; Beremand, M.N. Bioconversion of possible T-2 toxin precursors by a mutant strain of Fusarium sporotrichioides NRRL 3299. Appl. Environ. Microbiol. 1990, 56, 702-6.
45. McCormick, S.P.; Alexander, N.J.; Trapp, S.E.; Hohn, T.M. Disruption of TRI101, the gene encoding trichothecene 3-O-acetyltransferase, from Fusarium sporotrichioides. Appl. Environ. Microbiol. 1999, 65, 5252-5256.
46. Alexander, N.J.; Hohn, T.M.; McCormick, S.P. The TRI11 gene of Fusarium sporotrichioides encodes a cytochrome P-450 monooxygenase required for C-15 hydroxylation in trichothecene biosynthesis. Appl. Environ. Microbiol. 1998, 64, 221-225.
47. McCormick, S.P.; Hohn, T.M.; Desjardins, A.E. Isolation and characterization of Tri3, a gene encoding 15-O-acetyltransferase from Fusarium sporotrichioides. Appl. Environ. Microbiol. 1996, 62, 353-9.
48. Desjardins, A.E. Natural product chemistry meets genetics: when is a genotype a chemotype? J. Agric. Food Chem. 2008, 56, 7587-7592.
49. Lee, T.; Han, Y.K.; Kim, K.H.; Yun, S.H.; Lee, Y.W. Tri13 and Tri7 determine deoxynivalenol- and nivalenol-producing chemotypes of Gibberella zeae. Appl. Environ. Microbiol. 2002, 68, 2148-2154.
50. Brown, D.W.; McCormick, S.P.; Alexander, N.J.; Proctor, R.H.; Desjardins, A.E. A genetic and biochemical approach to study trichothecene diversity in Fusarium sporotrichioides and Fusarium graminearum. Fungal Genet. Biol. 2001, 32, 121-133.
51. Rocha, O.; Ansari, K.; Doohan, F.M. Effects of trichothecene mycotoxins on eukaryotic cells: A review. Food Addit. Contam. 2005, 22, 369-378.
52. McLaughlin, C.S.; Vaughn, M.H.; Campbell, J.M.; Wei, C.M.; Stafford, M.E. Mycotoxins in Human and Health; Rodricks, J.V., Hesseltine, C.W., Mehlman, M.A., Eds.; Pathotox Publishers: Park Forest South, Illinois, 1977; pp. 263-275.
53. Ueno, Y. Mode of action of trichothecenes. Ann. Nutr. Aliment. 1977, 31, 885-900.
54. Ueno, Y. The toxicology of mycotoxins. Crit. Rev. Toxicol. 1985, 14, 99-133.
55. Minervini, F.; Fornelli, F.; Flynn, K.M. Toxicity and apoptosis induced by the mycotoxins nivalenol, deoxynivalenol and fumonisin B1 in a human erythroleukemia cell line. Toxicol. In Vitro 2004, 18, 21-28.
56. Thompson, W.L.; Wannemacher, R.W.J. Structure-function relationships of 12,13- epoxytrichothecene mycotoxins in cell culture comparison to whole animal lethality. Toxicon 1986, 24, 985-994.
57. Pace, J.G.; Watts, M.R.; Canterbury, W.J. T-2 Mycotoxin inhibits mitochondrial protein synthesis. Toxicon 1988, 26, 77-86.
58. Bunner, D.L.; Morris, E.R. Alteration of multiple cell Membrane functions in L-6 myoblasts by T-2 toxin an important mechanism of action. Toxicol. Appl. Pharmacol. 1988, 92, 113-121.
59. Kang, Z.; Buchenauer, H. Immunocytochemical localization of Fusarium toxins in infected wheat spikes by Fusarium culmorum. Physiol. Mol. Plant Pathol. 1999, 55, 275-288.
60. Islam, Z.; Pestka, J.J. Role of IL-1beta in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice. Toxicol. Sci. 2003, 74, 93-102.
61. Shifrin, V.I.; Anderson, P. Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis. J. Biol. Chem. 1999, 274, 13985-13992.
62. Yoshino, N.; Takizawa, M.; Tashiro, F.; Honda, M.; Ueno, Y. T-2 toxin induced apoptosis in human peripheral blood lymphocytes in vitro. Res. Commun. Biochem. Cell Mol. Biol. 1997, 1, 218-228.
63. Mayer, C.F. Endemic panmyelotoxicosis in the Russian grain belt. I. The clinical aspects of alimentary toxic aleukia (ATA); a comprehensive review. Mil. Surg. 1953, 113, 173-189.
64. Yagen, B.; Joffe, A.Z. Screening of toxic isolates of Fusarium poae and Fusarium sporotrichioides involved in causing alimentary toxic aleukia. Appl. Environ. Microbiol. 1976, 32, 423-427.
65. Del, P.E.M.; Fernandes, J.M.C.; Bergstrom, G.C. Influence of growth stage on fusarium head blight and deoxynivalenol production in wheat. J. Phytopathol. 2007, 155, 577-581.
66. Bushnell, W.R.; Hazen, B.E.; Pritsch, C. Histology and physiology of fusarium head blight. In Fusarium Head Blight of Wheat and Barley; Leonard, K.J., Bushnell, W.R., Eds.; The American Phytopathological Society: St. Paul, Minnesota, USA, 2003; Chapter 3, pp. 44-83.
67. Steffenson, B.J. Fusarium head blight of barley: Impact, epidemics, management, and strategies for identifying and utilizing genetic resistance. In Fusarium Head Blight of Wheat and Barley; Leonard, K.J., Bushnell, W.R., Eds.; The American Phytopathological Society: St. Paul, Minnesota, USA, 2003; Chapter 10, pp. 241-295.
68. Hart, L.P.; Pestka, J.J.; Liu, M.T. Effect of kernel development and wet periods on production of deoxynivalenol in wheat infected with Gibberella zeae. Phytopathology 1984, 74, 1415-1418.
69. Pestka, J.J.; Smolinski, A.T. Deoxynivalenol: Toxicology and potential effects on humans. J. Toxicol. Environ. Health B Crit. Rev. 2005, 8, 36-39.
70. Rotter, B.A.; Prelusky, D.B.; Pestka, J.J. Toxicology of deoxynivalenol (Vomitoxin). J. Toxicol. Environ. Health 1996, 48, 1-34.
71. Wolpert, T.J.; Dunkle, L.D.; Ciuffetti, L.M. Host-selective toxins and avirulence determinants: What's in a name? Annu. Rev. Phytopathol. 2002, 40, 251-85.
72. Tanaka, A.; Shiotani, H.; Yamamoto, M.; Tsuge, T. Insertional mutagenesis and cloning of the genes required for biosynthesis of the host-specific AK-toxin in the Japanese pear pathotype of Alternaria alternata. Mol. Plant-Microbe Interact. 1999, 12, 691-702.
73. Navarre, D.A.; Wolpert, T.J. Victorin induction of an apoptotic/senescence-like response in oats. Plant Cell 1999, 11, 237-249.
74. Baker, S.E.; Kroken, S.; Inderbitzin, P.; Asvarak, T.; Li, B.Y.; Shi, L.; Yoder, O.C.; Turgeon, B.G. Two polyketide synthase-encoding genes are required for biosynthesis of the polyketide virulence factor, T-toxin, by Cochliobolus heterostrophus. Mol. Plant-Microbe Interact. 2006, 19, 139-149.
75. Reino, J.L.; Hernandez, G.R.; Duran, P.R.; Collado, I.G. Virulence-toxin production relationship in isolates of the plant pathogenic fungus Botrytis cinerea. J. Phytopathol. 2004, 152, 563-566.
76. Cotty, P.J.; Misaghi, I.J. Zinniol Production by Alternaria Species. Phytopathology 1984, 74, 785-788.
77. Beremand, M.N.; Desjardins, A.E.; Hohn, T.M.; Vanmiddlesworth, F.L. Survey of Fusarium sambucinum Equals Gibberella pulicaris for Mating Type Trichothecene production and other selected tTraits. Phytopathology 1991, 81, 1452-1458.
78. Miedaner, T.; Reinbrecht, C.; Schilling, A.G. Association among aggressiveness, fungal colonization, and mycotoxin production of 26 isolates of Fusarium graminearum in winter rye head blight. Z. Pflanzenkr. Pflanzenschutz 2000, 107, 124-134.
79. Perkowski, J.; Kiecana, I.; Schumacher, U.; Mueller, H.M.; Chelkowski, J.; Golinski, P. Head blight and biosynthesis of Fusarium toxins in barley kernels field inoculated with Fusarium culmorum. Eur. J. Plant Pathol. 1996, 102, 491-496.
80. Snijders, C.H.A.; Perkowski, J. Effects of head blight caused by Fusarium culmorum on toxin content and weight of wheat kernels. Phytopathology 1990, 80, 570.
81. Mesterházy, Á.; Bartók, T.; Mirocha, C.G.; Komoroczy, R. Nature of wheat resistance to fusarium head blight and the role of deoxynivalenol for breeding. Plant Breed. 1999, 118, 97-110.
82. Arseniuk, E.; Góral, T.; Czembor, H.J. Reaction of triticale, wheat and rye accessions to graminaceous Fusarium spp. infection at the seedling and adult plant growth stages. Euphytica 1993, 70, 175-183.
83. Boutigny, A.L.; Richard, F.F.; Barreau, C. Natural mechanisms for cereal resistance to the accumulation of Fusarium trichothecenes. Eur. J. Plant Pathol. 2008, 121, 411-423.
84. Bai, G.-H.; Desjardins, A.E.; Plattner, R.D. Deoxynivalenol-nonproducing Fusarium graminearum causes initial infection, but does not cause disease spread in wheat spikes. Mycopathologia 2002, 153, 91-8.
85. Maier, F.J.; Miedaner, T.; Hadeler, B.; Felk, A.; Salomon, S.; Lemmens, M.; Kassner, H.; Schaefer, W. Involvement of trichothecenes in fusarioses of wheat, barley and maize evaluated by gene disruption of the trichodiene synthase (Tri5) gene in three field isolates of different chemotype and virulence. Mol. Plant Pathol. 2006, 7, 449-461.
86. Jansen, C.; von, W.D.; Schaefer, W.; Kogel, K.H.; Felk, A.; Maier, F.J. Infection patterns in barley and wheat spikes inoculated with wild-type and trichodiene synthase gene disrupted Fusarium graminearum. Proc. Natl. Acad. Sci. USA 2005, 102, 16892-16897.
87. Mesterhazy, A. Types and components of resistance to fusarium head blight of wheat. Plant Breed. 1995, 114, 377-386.
88. Reid, L.M.; Mather, D.E.; Hamilton, R.I.; Bolton, A.T. Genotypic differences in the resistance of maize silk to Fusarium graminearum. Can. J. Plant Pathol. 1992, 14, 211-214.
89. Chungu, C.; Mather, D.E.; Reid, L.M.; Hamilton, R.I. Inheritance of kernel resistance to Fusarium graminearum in maize. J. Hered. 1996, 87, 382-385.
90. Schroeder, H.W.; Christensen, J.J. Factors affecting resistance of wheat to scab by Gibberella zeae. Phytopathology 1963, 42, 720-727.
91. Dill-Macky, R. Inoculation methods and evaluation of fusarium head blight resistance in wheat. In Fusarium Head Blight of Wheat and Barley; Leonard, K.J., Bushnell, W.R., Eds.; The American Phytopathological Society: St. Paul, Minnesota, USA, 2003; Chapter 8, pp. 184-210.
92. Rudd, J.C.; Horsley, R.D.; McKendry, A.L.; Elias, E.M. Host plant resistance genes for fusarium head blight: sources, mechanisms, and utility in conventional breeding systems. Crop Sci. 2001, 41, 620-627.
93. Eudes, F.; Zhou, W.; Badea, A.; Laroche, A. Toward the development of fusarium head blight resistance and reduced levels of mycotoxin in wheat and barley. Recent Res. Devel. Plant Pathology 2004, 3, 1-33.
94. Mesterházy, Á.; Tóth, B.; Bartók, T.; Varga, M. Breeding strategies against FHB in winter wheat and their relation to type I resistance Cereal Res. Commun. 2008, 36, 37-43.
95. Kang, Z.; Buchenauer, H. Ultrastructural immunocytochemical investigation of pathogen development and host responses in resistant and susceptible wheat spikes infected by Fusarium culmorum. Physiol. Mol. Plant Pathol. 2000, 57, 255-268.
96. Ilgen, P.; Maier, F.J.; Schäfer, W. Trichothecenes and lipases are host-induced and secreted virulence factors of Fusarium graminearum. Cereal Res. Commun. 2008, 36, 421-428.
97. Miller, J.D.; Young, J.C.; Sampson, D.R. Deoxynivalenol and fusarium head blight resistance in spring cereals. J. Phytopathol. 1985, 113, 359-367.
98. Wang, Y.Z.; Miller, J.D. Effects of Fusarium graminearum metabolites on wheat tissue in relation to fusarium head blight resistance. J. Phytopathol. 1988, 122, 118-125.
99. Mesterhazy, Á. Breeding wheat for fusarium head blight resistance in Europe. In Fusarium Head Blight of Wheat and Barley; Leonard, K.J., Bushnell, W.R., Eds.; The American Phytopathological Society: St. Paul, Minnesota, USA, 2003; Chapter 13, pp. 363-381.
100. Miedaner, T. Breeding wheat and rye for resistance to Fusarium diseases. Plant Breed. 1997, 116, 201-220.
101. Tekauz, A.; McCallum, B.; Gilbert, J. Review: Fusarium head blight of barley in western Canada. Can. J. Plant Pathol. 2000, 22, 9-16.
102. Tekauz, A.; McCallum, B.; Ames, N.; Fetch, J.M. Fusarium head blight of oat-current status in western Canada. Can. J. Plant Pathol. 2004, 26, 473-479.
103. Tekauz, A.; Mitchell Fetch, J.W.; Rossnagel, B.G.; Savard, M.E. Progress in assessing the impact of fusarium head blight on oat in western Canada and screening of avena germplasm for resistance Cereal Res. Commun. 2008, 36, 49-56.
104. Bjørnstad, Å.; Skinnes, H. Resistance to Fusrium infection in oats (Avena sativa L.) Cereal Res. Commun. 2008, 36, 57-62.
105. Cooper, B.; Skoglund, L.; Askelson, S.; Van Horn, J. In 2nd International Symposium on Fusarium Head Blight: Orlando, FL, USA, 2004; pp. 44-48.
106. de la Pena, R.C.; Smith, K.P.; Capettini, F.; Muehlbauer, G.J.; Gallo, M.M.; Dill, M.R.; Somers, D.A.; Rasmusson, D.C. Quantitative trait loci associated with resistance to fusarium head blight and kernel discoloration in barley. Theor. Appl. Genet. 1999, 99, 561-569.
107. Ma, Z.; Steffenson, B.J.; Prom, L.K.; Lapitan, N.L. Mapping of Quantitative Trait Loci for Fusarium Head Blight Resistance in Barley. Phytopathology 2000, 90, 1079-1088.
108. Zhu, H.; Gilchrist, L.; Hayes, P.; Kleinhofs, A.; Kudrna, D.; Liu, Z.; Prom, L.; Steffenson, B.; Toojinda, T.; Vivar, H. Does function follow form? Principal QTLs for fusarium head blight (FHB) resistance are coincident with QTLs for inflorescence traits and plant height in a doubled- haploid population of barley. Theor. Appl. Genet. 1999, 99, 1221-1232.
109. Oliver, R.E.; Cal, X.; Friesen, T.L.; Halley, S.; Stack, R.W.; Xu, S.S. Evaluation of fusarium head blight resistance in tetraploid wheat (Triticum turgidum L.). Crop Sci. 2008, 48, 213-222.
110. Bürstmayr, H.; Ban, T.; Anderson, A.J. QTL mapping and marker-assisted selection for fusarium head blight resistance in wheat: A review. Plant Breed. 2008, In press.
111. Anderson, J.A. Marker-assisted selection for fusarium head blight resistance in wheat. Int. J. Food Microbiol. 2007, 119, 51-53.
112. Liu, S.; Pumphrey, M.O.; Gill, B.S.; Trick, H.N.; Zhang, J.X.; Dolezel, J.; Chalhoub, B.; Anderson, J.A. Toward positional cloning of Fhb1, a major QTL for fusarium head blight resistance in wheat Cereal Res. Commun. 2008, 36, 195-201.
113. Han, F.P.; Fedak, G.; Ouellet, T.; Dan, H.; Somers, D.J. Mapping of genes expressed in Fusarium graminearum-infected heads of wheat cultivar 'Frontana'. Genome 2005, 48, 88-96.
114. Mardi, M.; Pazouki, L.; Delavar, H.; Kazemi, M.B.; Ghareyazie, B.; Steiner, B.; Nolz, R.; Lemmens, M.; Buerstmayr, H. QTL analysis of resistance to fusarium head blight in wheat using a 'Frontana'-derived population. Plant Breed. 2006, 125, 313-317.
115. Steiner, B.; Lemmens, M.; Griesser, M.; Scholz, U.; Schondelmaier, J.; Burstmayr, H. Molecular mapping of resistance to fusarium head blight in the spring wheat cultivar Frontana. Theor. Appl. Genet. 2004, 109, 215-24.
116. Couture, L. Susceptibility of spring cereal cultivars to seed contamination by Fusarium-Spp during inflorescence. Can. J. Plant Sci. 1982, 62, 29-34.
117. Klahr, A.; Zimmermann, G.; Wenzel, G.; Mohler, V. Effects of environment disease progress, plant height and heading date on the detection of QTLs or resistance to fusarium head blight in an European winter wheat cross. Euphytica 2007, 154, 17-28.
118. Draeger, R.; Gosman, N.; Steed, A.; Chandler, E.; Thomsett, M.; Srinivasachary; Schondelmaier, J.; Bürstmayr, H.; Lemmens, M.; Schmolke, M.; Mesterházy, Á.; Nicholson, P. Identification of QTLs for resistance to fusarium head blight, DON accumulation and associated traits in the winter wheat variety Arina. Theor. Appl. Genet. 2007, 115, 617-25.
119. Zhang, X.; Yang, S.; Zhou, Y.; He, Z.; Xia, X. Distribution of the Rht-B1b, Rht-D1b and Rht8 reduced height genes in autumn-sown Chinese wheats detected by molecular markers. Euphytica 2006, 152, 109-116.
120. Nicholson, P.; Sriniv Asachary, N.; Gosman, N.; Steed, A.; Chen, X. Role of phytohormone signalling in resistance of wheat to fusarium head blight Cereal Res. Commun. 2008, 36, 213-216.
121. Reid, L.M.; McDiarmid, G.; Parker, A.J.; Woldemariam, T. CO441 corn inbred line. Can. J. Plant Sci. 2003, 83, 79-80.
122. Ali, M.L.; Taylor, J.H.; Jie, L.; Sun, G.; William, M.; Kasha, K.J.; Reid, L. M.; Pauls, K.P. Molecular mapping of QTLs for resistance to Gibberella ear rot, in corn, caused by Fusarium graminearum. Genome 2005, 48, 521-533.
123. Pè, M.E.; Gianfranceschi, L.; Taramino, G.; Tarchini, R.; Angelini, P.; Dani, M.; Binelli, G. Mapping quantitative trait loci (QTLs) for resistance to Gibberella zeae infection in maize Mol. Gen. Genet. 1993, 241, 11-16.
124. Reinprecht, Y.; Wu, X.; Yan, S.; Labey, L.; Dasilva, E.; Martin, J.C.; Pauls, K.P. A microarray-based approach for identifying genes for resistance to Fusarium graminearum in maize (Zea Mays L.) Cereal Res. Commun. 2008, 36, 253-259.
125. Dodds, P.N.; Lawrence, G.J.; Catanzariti, A.M.; Teh, T.; Wang, C.I.A.; Ayliffe, M.A.; Kobe, B.; Ellis, J.G. Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes. Proc. Natl. Acad. Sci. USA 2006, 103, 8888-8893.
126. Zhang, G.; Mergoum, M. Molecular mapping of kernel shattering and its association with fusarium head blight resistance in a Sumai3 derived population. Theor. Appl. Genet. 2007, 115, 757-766.
127. Bai, G.H.; Plattner, R.; Desjardins, A.; Kolb, F. Resistance to fusarium head blight and deoxynivalenol accumulation in wheat. Plant Breed. 2001, 120, 1-6.
128. Geddes, J.; Eudes, F.; Tucker, J.R.; Legge, W.G.; Selinger, L.B. Evaluation of inoculation methods on infection and deoxynivalenol production by Fusarium graminearum on barley. Can. J. Plant Pathol. 2008, 30, 66-73.
129. Bruins, M.B.M.; Karsai, I.; Schepers, J.; Snijders, C.H.A. Phytotoxicity of deoxynivalenol to wheat tissue with regard to in vitro selection for fusarium head blight resistance. Plant Sci. 1993, 94, 195-206.
130. Fadel, F.; Wenzel, G. In vitro selection for tolerance to Fusarium in F-1 microspore populations of wheat. Plant Breed. 1993, 110, 89-95.
131. Eudes, F.; Comeau, A.; Rioux, S.; Collin, J. Trichothecene-mediated in vitro selection in wheat for reduced mycotoxin accumulation caused by Fusarium graminearum. Trichothecene-mediated in vitro selection in wheat for reduced mycotoxin accumulation caused by Fusarium graminearum 2008, In Press.
132. Campbell, M.A.; Fitzgerald, H.A.; Ronald, P.C. Engineering pathogen resistance in crop plants. Transgenic Res. 2002, 11, 599-613.
133. Dahleen, L.S.; Okubara, P.A.; Blechl, A.E. Transgenic approaches to combat fusarium head blight in wheat and barley. Crop Sci. 2001, 41, 628-637.
134. Munkvold, G.P. Epidemiology of Fusarium diseases and their mycotoxins in maize ears. Eur. J. Plant Pathol. 2003, 109, 705-713.
135. Ehrlich, K.C.; Daigle, K.W. Protein Synthesis Inhibition by 8 Oxo-12 13-Epoxytrichothecenes. Biochim. Biophys. Acta 1987, 923, 206-213.
136. Kimura, M.; Kaneko, I.; Komiyama, M.; Takatsuki, A.; Koshino, H.; Yoneyama, K.; Yamaguchi, I. Trichothecene 3-O-acetyltransferase protects both the producing organism and transformed yeast from related mycotoxins. Cloning and characterization of Tri101. J. Biol. Chem. 1998, 273, 1654-1661.
137. Eriksen, G.S.; Pettersson, H.; Lundh, T. Comparative cytotoxicity of deoxynivalenol, nivalenol, their acetylated derivatives and de-epoxy metabolites. Food Chem. Toxicol. 2004, 42, 619-624.
138. Alexander, N.J. The TRI101 story: engineering wheat and barley to resist fusarium head blight. World Mycotoxin J. 2008, 1, 31-37.
139. Ohsato, S.; Ochiai, F.T.; Nishiuchi, T.; Takahashi, A.N.; Koizumi, S.; Hamamoto, H.; Kudo, T.; Yamaguchi, I.; Kimura, M. Transgenic rice plants expressing trichothecene 3-O-acetyltransferase show resistance to the Fusarium phytotoxin deoxynivalenol. Plant Cell Rep. 2007, 26, 531-538.
140. Okubara, P.A.; Blechl, A.E.; McCormick, S.P.; Alexander, N.J.; Dill, M.R.; Hohn, T.M. Engineering deoxynivalenol metabolism in wheat through the expression of a fungal trichothecene acetyltransferase gene. Theor. Appl. Genet. 2002, 106, 74-83.
141. Alexander, N.J.; McCormick, S.P.; Hohn, T.M. TRI12, a trichothecene efflux pump from Fusarium sporotrichioides: Gene isolation and expression in yeast. Mol. Gen. Genet. 1999, 261, 977-984.
142. Poppenberger, B.; Berthiller, F.; Lucyshyn, D.; Sieberer, T.; Schuhmacher, R.; Krska, R.; Kuchler, K.; Glossl, J.; Luschnig, C.; Adam, G. Detoxification of the Fusarium mycotoxin deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana. J. Biol. Chem. 2003, 278, 47905-47914.
143. Berthiller, F.; Dall'Asta, C.; Schuhmacher, R.; Lemmens, M.; Adam, G.; Krska, R. Masked mycotoxins: Determination of a deoxynivalenol glucoside in artificially and naturally contaminated wheat by liquid chromatography-tandem mass spectrometry. J. Agric. Food Chem. 2005, 53, 3421-3425.
144. Dall'Asta, C.; Berthiller, F.; Schuhmacher, R.; Adam, G.; Lemmens, M.; Krska, R. DON- glycosides: Characterisation of synthesis products and screening for their occurrence in DON- treated wheat samples. Mycotox. Res. 2005, 21, 123-127.
145. Lemmens, M.; Scholz, U.; Berthiller, F.; Dall'Asta, C.; Koutnik, A.; Schuhmacher, R.; Adam, G.; Bürstmayr, H.; Mesterházy, Á.; Krska, R.; Ruckenbauer, P. The ability to detoxify the mycotoxin deoxynivalenol colocalizes with a major quantitative trait locus for fusarium head blight resistance in wheat. Mol. Plant-Microbe Interact. 2005, 18, 1318-24.
146. Gareis, M.; Bauer, J.; Thiem, J.; Plank, G.; Grabley, S.; Gedek, B. Cleavage of zearalenone- glycoside, a masked mycotoxin, during digestion in swine. Zentralbl. Veterinarmed. B 1990, 37, 236-240.
147. Savard, M.E. Deoxynivalenol fatty acid and glucoside conjugates. J. Agric. Food Chem. 1991, 39, 570-574.
148. Tanaka, T.; Yoneda, A.; Inoue, S.; Sugiura, Y.; Ueno, Y. Simultaneous determination of trichothecene mycotoxins and zearalenone in cereals by gas chromatography-mass spectrometry. J. Chromatogr. A 2000, 882, 23-28.
149. Krska, R.; Baumgartner, S.; Josephs, R. The state-of-the-art in analysis of type-A and -B trichothecene mycotoxins in cereals. Fresenius J. Anal. Chem. 2001, 371, 285-299.
150. Berthiller, F.; Schuhmacher, R.; Buttinger, G.; Krska, R. Rapid simultaneous determination of major type A- and B-trichothecenes as well as zearalenone in maize by high performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2005, 1062, 209-216.
151. Krska, R.; Welzig, E.; Berthiller, F.; Molinelli, A.; Mizaikoff, B. Advances in the analysis of mycotoxins and its quality assurance. Food Addit. Contam. 2005, 22, 345-353.
152. Zöllner, P.; Mayer-Helm, B. 2006. Trace mycotoxin analysis in complex biological and food matrices by liquid chromatography-atmospheric pressure ionisation mass spectrometry. J. Chromatogr. A 2006, 1136, 123-169
153. Krska, R.; Welzig, E.; Boudra, H. Analysis of Fusarium toxins in feed. Anim. Feed Sci. Technol. 2007, 137, 241-264.
154. Beremand, M.N. Isolation and characterization of mutants blocked in T-2 toxin biosynthesis. Appl. Environ. Microbiol. 1987, 53, 1855-1859.
155. Beremand, M.N.; Desjardins, A.E. Trichothecene biosynthesis in Gibberella pulicaris: Inheritance of C-8 hydroxylation. J. Indus. Microbiol. 1989, 3, 167-174.
156. Meek, I.B.; Peplow, A.W.; Ake, C., Jr.; Phillips, T.D.; Beremand, M.N. Tri1 encodes the cytochrome P450 monooxygenase for C-8 hydroxylation during trichothecene biosynthesis in Fusarium sporotrichioides and resides upstream of another new Tri gene. Appl. Environ. Microbiol. 2003, 69, 1607-1613.
157. Tokai, T.; Koshino, H.; Takahashi, A.N.; Sato, M.; Fujimura, M.; Kimura, M. Fusarium Tri4 encodes a key multifunctional cytochrome P450 monooxygenase for four consecutive oxygenation steps in trichothecene biosynthesis. Biochem. Biophys. Res. Commun. 2007, 353, 412-417.
158. Hohn, T.M.; Beremand, P.D. Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides. Gene 1989, 79, 131-138.
159. McCormick, S.P.; Alexander, N.J. Fusarium Tri8 encodes a trichothecene C-3 esterase. Appl. Environ. Microbiol. 2002, 68, 2959-2964.
160. McCormick, S.P.; Hohn, T.M. Accumulation of trichothecenes in liquid cultures of a Fusarium sporotrichioides mutant lacking a functional trichothecene C-15 hydroxylase. Appl. Environ. Microbiol. 1997, 63, 1685-1688.
161. Kim, H.S.; Lee, T.; Dawlatana, M.; Yun, S.H.; Lee, Y.W. Polymorphism of trichothecene biosynthesis genes in deoxynivalenol- and nivalenol-producing Fusarium graminearum isolates. Mycol. Res. 2003, 107, 190-197.
162. Peplow, A.W.; Meek, I.B.; Wiles, M.C.; Phillips, T.D.; Beremand, M.N. Tri16 is required for esterification of position C-8 during trichothecene mycotoxin production by Fusarium sporotrichioides. Appl. Environ. Microbiol. 2003, 69, 5935-5940.
163. Kimura, M.; Tokai, T.; O'Donnell, K.; Ward, T.J.; Fujimura, M.; Hamamoto, H.; Shibata, T.; Yamaguchi, I. The trichothecene biosynthesis gene cluster of Fusarium graminearum F15 contains a limited number of essential pathway genes and expressed non-essential genes. FEBS Lett. 2003, 539, 105-110.
164. Proctor, R.H.; Hohn, T.M.; McCormick, S.P.; Desjardins, A.E. Tri6 encodes an unusual zinc finger protein involved in regulation of trichothecene biosynthesis in Fusarium sporotrichioides. Appl. Environ. Microbiol. 1995, 61, 1923-1930.
165. Hohn, T.M.; Krishna, R.; Proctor, R.H. Characterization of a transcriptional activator controlling trichothecene toxin biosynthesis. Fungal Genet. Biol. 1999, 26, 224-235.
166. Tag, A.G.; Garifullina, G.F.; Peplow, A.W.; Ake, C., Jr.; Phillips, T.D.;
167. Alexander, N.J.; Hohn, T.M.; McCormick, S.P. Molecular characterization of TRI12 which encodes an apparent transport protein involved in trichothecene production by Fusarium sporotrichioides. Cereal Res. Commun. 1997, 25, 347-348.
168. Brown, D.W.; Dyer, R.B.; McCormick, S.P.; Kendra, D.F.; Plattner, R.D. Functional demarcation of the Fusarium core trichothecene gene cluster. Fungal Genet. Biol. 2004, 41, 454-462.
169. Hohn, T.M.; McCormick, S.P.; Desjardins, A.E. Evidence for a gene cluster involving trichothecene-pathway biosynthetic genes in Fusarium sporotrichioides. Curr. Genet. 1993, 24, 291-295.
170. Kimura, M.; Tokai, T.; Takahashi, A.N.; Ohsato, S.; Fujimura, M. Molecular and genetic studies of Fusarium trichothecene biosynthesis: Pathways, genes, and evolution. Biosci. Biotechnol. Biochem. 2007, 71, 2105-2123.
171. Ward, T.J.; Bielawski, J.P.; Kistler, H.C.; Sullivan, E.; O'Donnell, K. Ancestral polymorphism and adaptive evolution in the trichothecene mycotoxin gene cluster of phytopathogenic Fusarium. Proc. Natl. Acad. Sci. USA 2002, 99, 9278-9283.
172. McCormick, S.P. The role of DON in pathogenicity. In Fusarium Head Blight of Wheat and Barley; Leonard, K.J., Bushnell, W.R., Eds.; The American Phytopathological Society: St. Paul, Minnesota, USA, 2003; Chapter 7, pp. 165-183.
173. Gottschalk, C.; Barthel, J.; Engelhardt, G.; Bauer, J.; Meyer, K. Occurrence of type A trichothecenes in conventionally and organically produced oats and oat products. Mol. Nutr. Food Res. 2007, 51, 1547-1553.
174. Brown, D.W.; Proctor, R.H.; Dyer, R.B.; Plattner, R.D. Characterization of a Fusarium 2-gene cluster involved in trichothecene C-8 modification. J. Agric. Food Chem. 2003, 51, 7936-7944.
175. McCormick, S.P.; Alexander, N.J.; Proctor, R.H. Heterologous expression of two trichothecene P450 genes in Fusarium verticillioeds. Can. J. Microbiol. 2006, 52, 220-226.