In silico and in vitro modeling of hepatocyte drug transport processes: Importance of ABCC2 expression levels in the disposition of carboxydichlorofluroscein

Drug Metabolism and Disposition

Volumn 37, Issue 2, 2009, Pages 391-399

  Howe, Katharine ^a   Gibson, G Gordon ^a   Coleman, Tanya ^b   Plant, Nick ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYDICHLOROFLUORESCEIN; CARRIER PROTEIN; DICHLOROFLUORESCEIN; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; PROTEIN ABCC2; UNCLASSIFIED DRUG; VERLUKAST;

ANIMAL CELL; ARTICLE; COMPUTER MODEL; DRUG DISPOSITION; DRUG TRANSPORT; IN VITRO STUDY; LIVER CELL; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; SIMULATION; TRANSPORT KINETICS;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; FLUORESCEINS; GENE EXPRESSION; HEPATOCYTES; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHYSIOLOGICAL PROCESSES; RATS;

RATTUS;

EID: 59649087914     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.022921     Document Type: Article

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