Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system

International Journal of Biochemistry and Cell Biology

Volumn 41, Issue 5, 2009, Pages 1205-1215

  Ebstein, Frédéric ^a   Lange, Nicole ^a   Urban, Sabrina ^a   Seifert, Ulrike ^a   Krüger, Elke ^a   Kloetzel, Peter Michael ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cross presentation; Dendritic cells; FAT10; ISG15; UBE2L6; Ubiquitin proteasome system

Indexed keywords

CD40 LIGAND; CYTOKINE; INTERFERON; LIPOPOLYSACCHARIDE; PROTEASOME; UBIQUITIN;

ANTIGEN PRESENTING CELL; ARTICLE; AUTOCRINE EFFECT; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; DENDRITIC CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; T LYMPHOCYTE; UBIQUITINATION;

ANTIGEN PRESENTATION; CD40 LIGAND; CROSS-PRIMING; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; GENE SILENCING; HUMANS; LIPOPOLYSACCHARIDES; POLY I-C; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITINS;

EID: 59649085296     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.10.023     Document Type: Article

References (40)

1. Banchereau J., Schuler-Thurner B., Palucka A.K., and Schuler G. Dendritic cells as vectors for therapy. Cell 106 (2001) 271-274
2. Bates E.E., Ravel O., Dieu M.C., Ho S., Guret C., Bridon J.M., et al. Identification and analysis of a novel member of the ubiquitin family expressed in dendritic cells and mature B cells. Eur J Immunol 27 (1997) 2471-2477
3. Canaan A., Yu X., Booth C.J., Lian J., Lazar I., Gamfi S.L., et al. FAT10/diubiquitin-like protein-deficient mice exhibit minimal phenotypic differences. Mol Cell Biol 26 (2006) 5180-5189
4. Caux C., Massacrier C., Vanbervliet B., Dubois B., Van Kooten C., Durand I., et al. Activation of human dendritic cells through CD40 cross-linking. J Exp Med 180 (1994) 1263-1272
5. Cella M., Salio M., Sakakibara Y., Langen H., Julkunen I., and Lanzavecchia A. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J Exp Med 189 (1999) 821-829
6. Chiu Y.H., Sun Q., and Chen Z.J. E1-L2 activates both ubiquitin and FAT10. Mol Cell 27 (2007) 1014-1023
7. Dastur A., Beaudenon S., Kelley M., Krug R.M., and Huibregtse J.M. Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells. J Biol Chem 281 (2006) 4334-4338
8. De Smedt T., Pajak B., Muraille E., Lespagnard L., Heinen E., De Baetselier P., et al. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J Exp Med 184 (1996) 1413-1424
9. Elliott T., and Neefjes J. The complex route to MHC class I-peptide complexes. Cell 127 (2006) 249-251
10. Fonteneau J.F., Kavanagh D.G., Lirvall M., Sanders C., Cover T.L., Bhardwaj N., et al. Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells. Blood 102 (2003) 4448-4455
11. Fonteneau J.F., Larsson M., Somersan S., Sanders C., Munz C., Kwok W.W., et al. Generation of high quantities of viral and tumor-specific human CD4+ and CD8+ T-cell clones using peptide pulsed mature dendritic cells. J Immunol Methods 258 (2001) 111-126
12. Glickman M.H., and Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82 (2002) 373-428
13. Hipp M.S., Kalveram B., Raasi S., Groettrup M., and Schmidtke G. FAT10, a ubiquitin-independent signal for proteasomal degradation. Mol Cell Biol 25 (2005) 3483-3491
14. Hipp M.S., Raasi S., Groettrup M., and Schmidtke G. NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation. J Biol Chem 279 (2004) 16503-16510
15. Jonuleit H., Kuhn U., Muller G., Steinbrink K., Paragnik L., Schmitt E., et al. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 27 (1997) 3135-3142
16. Kanzler H., Barrat F.J., Hessel E.M., and Coffman R.L. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 13 (2007) 552-559
17. Kloetzel P.M., and Ossendorp F. Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr Opin Immunol 16 (2004) 76-81
18. Li X.L., and Hassel B.A. Involvement of proteasomes in gene induction by interferon and double-stranded RNA. Cytokine 14 (2001) 247-252
19. Liu M., Li X.L., and Hassel B.A. Proteasomes modulate conjugation to the ubiquitin-like protein, ISG15. J Biol Chem 278 (2003) 1594-1602
20. Liu Y.C., Pan J., Zhang C., Fan W., Collinge M., Bender J.R., et al. A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2. Proc Natl Acad Sci U S A 96 (1999) 4313-4318
21. Liu Y.C., Penninger J., and Karin M. Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol 5 (2005) 941-952
22. Longman R.S., Braun D., Pellegrini S., Rice C.M., Darnell R.B., and Albert M.L. Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation. Blood 109 (2007) 1113-1122
23. Macagno A., Gilliet M., Sallusto F., Lanzavecchia A., Nestle F.O., and Groettrup M. Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation. Eur J Immunol 29 (1999) 4037-4042
24. Malakhov M.P., Malakhova O.A., Kim K.I., Ritchie K.J., and Zhang D.E. UBP43 (USP18) specifically removes ISG15 from conjugated proteins. J Biol Chem 277 (2002) 9976-9981
25. Menges M., Rossner S., Voigtlander C., Schindler H., Kukutsch N.A., Bogdan C., et al. Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity. J Exp Med 195 (2002) 15-21
26. Mukhopadhyay D., and Riezman H. Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 315 (2007) 201-205
27. Pitha-Rowe I., Hassel B.A., and Dmitrovsky E. Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. J Biol Chem 279 (2004) 18178-18187
28. Raasi S., Schmidtke G., de Giuli R., and Groettrup M. A ubiquitin-like protein which is synergistically inducible by interferon-gamma and tumor necrosis factor-alpha. Eur J Immunol 29 (1999) 4030-4036
29. Rock K.L., York I.A., Saric T., and Goldberg A.L. Protein degradation and the generation of MHC class I-presented peptides. Adv Immunol 80 (2002) 1-70
30. Schaft N., Dorrie J., Thumann P., Beck V.E., Muller I., Schultz E.S., et al. Generation of an optimized polyvalent monocyte-derived dendritic cell vaccine by transfecting defined RNAs after rather than before maturation. J Immunol 174 (2005) 3087-3097
31. Shen L., Sigal L.J., Boes M., and Rock K.L. Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity 21 (2004) 155-165
32. Shin E.C., Seifert U., Kato T., Rice C.M., Feinstone S.M., Kloetzel P.M., et al. Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection. J Clin Invest 116 (2006) 3006-3014
33. Steinman R.M., and Banchereau J. Taking dendritic cells into medicine. Nature 449 (2007) 419-426
34. Strehl B., Seifert U., Kruger E., Heink S., Kuckelkorn U., and Kloetzel P.M. Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing. Immunol Rev 207 (2005) 19-30
35. Whiteside T.L., Stanson J., Shurin M.R., and Ferrone S. Antigen-processing machinery in human dendritic cells: up-regulation by maturation and down-regulation by tumor cells. J Immunol 173 (2004) 1526-1534
36. Wong B.R., Parlati F., Qu K., Demo S., Pray T., Huang J., et al. Drug discovery in the ubiquitin regulatory pathway. Drug Discov Today 8 (2003) 746-754
37. Wong J.J., Pung Y.F., Sze N.S., and Chin K.C. HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. Proc Natl Acad Sci U S A 103 (2006) 10735-10740
38. Yewdell J.W. The seven dirty little secrets of major histocompatibility complex class I antigen processing. Immunol Rev 207 (2005) 8-18
39. Zhao C., Beaudenon S.L., Kelley M.L., Waddell M.B., Yuan W., Schulman B.A., et al. The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. Proc Natl Acad Sci U S A 101 (2004) 7578-7582
40. Zou W., and Zhang D.E. The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase. J Biol Chem 281 (2006) 3989-3994