Prolonged treatment of human osteoarthritic chondrocytes with insulin-like growth factor-I stimulates proteoglycan synthesis but not proteoglycan matrix accumulation in alginate cultures

Journal of Rheumatology

Volumn 30, Issue 7, 2003, Pages 1565-1570

  Loeser, Richard F ^b   Todd, Marque D ^c   Seely, B Lynn ^a  

^a Cytyc Health Corporation   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c NONE

Author keywords

Cartilage repair; Chondrocyte; Insulin like growth factor I; Osteoarthritis; Osteogenic protein 1

Indexed keywords

ALGINIC ACID; DIMETHYLMETHYLENE BLUE; METHYLENE BLUE; OSTEOGENIC PROTEIN 1; PROTEOGLYCAN; RECOMBINANT SOMATOMEDIN C; SULFATE; UNCLASSIFIED DRUG;

ARTICLE; CARTILAGE CELL; CELL ASSAY; CELL CULTURE; CELL ISOLATION; CELL STIMULATION; DOSE RESPONSE; HUMAN; HUMAN CELL; ISOTOPE LABELING; KNEE OSTEOARTHRITIS; MEASUREMENT; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS;

AGED; AGED, 80 AND OVER; ALGINATES; BONE MORPHOGENETIC PROTEINS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR MATRIX; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KNEE JOINT; MIDDLE AGED; OSTEOARTHRITIS; PROTEOGLYCANS; RECOMBINANT PROTEINS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0037490969     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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