The ins and outs of biological zinc sites

BioMetals

Volumn 22, Issue 1, 2009, Pages 141-148

  Auld, David S ^a  

^a BOSTON COLLEGE   (United States)

Author keywords

Alcohol dehydrogenase; Carbonic anhydrase; Carboxypeptidase; Chelation; Chelators; D pencillamine; Matrix metalloproteinase; Metalloenzymes; Thionein; X ray structure; Zinc; Zinc enzymes

Indexed keywords

ALCOHOL DEHYDROGENASE; CARBONATE DEHYDRATASE; GELATINASE A; INTERSTITIAL COLLAGENASE; MUTANT PROTEIN; PENICILLAMINE; PROMATRIX METALLOPROTEASE; PROTEIN PRECURSOR; PROTEINASE; UNCLASSIFIED DRUG; ZINC; ZINC BINDING PROTEIN; ZINC PROTEASE;

BINDING SITE; CATALYSIS; CHELATION; CONFERENCE PAPER; ENZYME INHIBITION; ENZYME STABILITY; HUMAN; HYDROGEN BOND; HYDROPHILICITY; METAL BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

ALCOHOL DEHYDROGENASE; AMINO ACID SEQUENCE; BINDING SITES; CARBONIC ANHYDRASES; CATALYSIS; HUMANS; METALLOPROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN PRECURSORS; SEQUENCE ALIGNMENT; ZINC;

EID: 59449107552     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-008-9184-1     Document Type: Conference Paper

References (35)

1. C Andreini L Banci I Bertini A Rosato 2006 Counting the zinc-proteins encoded in the human genome J Proteome Res 5 196 201 10.1021/pr050361j
2. C Andreini L Banci I Bertini A Rosato 2006 Zinc through the three domains of life J Proteome Res 5 3173 3178 10.1021/pr0603699
3. P Argos RM Garavito W Eventoff MG Rossmann CI Branden 1978 Similarities in active center geometries of zinc-containing enzymes, proteases and dehydrogenases J Mol Biol 126 141 158 10.1016/0022-2836(78)90356-X
4. DS Auld 1988 Use of chelating agents to inhibit enzymes Methods Enzymol 158 110 114 10.1016/0076-6879(88)58051-5
5. DS Auld 1995 Removal and replacement of metal ions in metallopeptidases Methods Enzymol 248 228 242 10.1016/0076-6879(95)48016-1
6. DS Auld 2001 Zinc coordination sphere in biochemical zinc sites Biometals 14 271 313 10.1023/A:1012976615056
7. DS Auld 2001
8. DS Auld 2004
9. DS Auld 2004
10. DS Auld 2005
11. DS Auld T Bergman 2008 Medium- and short-chain dehydrogenase/reductase gene and protein families: the role of zinc for alcohol dehydrogenase structure and function Cell Mol Life Sci 65 3961 3970
12. T Bergman K Zhang C Palmberg H Jörnvall DS Auld 2008 Zinc binding to peptide Analogs of the structural zinc site in alcohol dehydrogenase: implications for an entatic state Cell Mol Life Sci 65 4019 4027 10.1007/s00018-008-8379-5
13. CR Chong DS Auld 2000 Inhibition of carboxypeptidase A by d-pencillamine: mechanism and implications for drug design Biochemistry 39 7580 7588 10.1021/bi000101+
14. CR Chong DS Auld 2007 Catalysis of zinc transfer by d-penicillamine to secondary chelators J Med Chem 50 5524 5527 10.1021/jm070803y
15. DW Christianson CA Fierke 1996 Carbonic anhydrase: evolution of the design of the zinc binding site by nature and by design Acc Chem Res 29 331 339 10.1021/ar9501232
16. H Eklund B Nordstrom E Zeppezauer G Soderlund I Ohlsson T Boiwe BO Soderberg O Tapia CI Branden A Akeson 1976 Three-dimensional structure of horse liver alcohol dehydrogenase at 2-4 A resolution J Mol Biol 102 27 59 10.1016/0022-2836(76)90072-3
17. D Jozic G Bourenkov NH Lim R Visse H Nagase W Bode K Maskos 2005 X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding J Biol Chem 280 9578 9585 10.1074/jbc.M411084200
18. JH Kagi A Schaffer 1988 Biochemistry of metallothionein Biochemistry 27 8509 8515 10.1021/bi00423a001
19. LL Kiefer SA Paterno CA Fierke 1995 Hydrogen bond network in the metal binding site of carbonic anhydrase enhances zinc affinity and catalytic efficiency J Am Chem Soc 117 6831 6837 10.1021/ja00131a004
20. A Krezel W Maret 2007 Different redox states of metallothionein/thionein in biological tissue Biochem J 402 551 558 10.1042/BJ20061044
21. CA Lesburg DW Christianson 1995 X-ray crystallographic studies of engineered hydrogen bond networks in a protein-zinc binding site J Am Chem Soc 117 6838 6844 10.1021/ja00131a005
22. W Maret 2004
23. E Morgunova A Tuuttila U Bergmann M Isupov Y Lindqvist G Schneider K Tryggvason 1999 Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed Science 284 1667 1670 10.1126/science.284.5420.1667 see comments
24. R Natesh SL Schwager ED Sturrock KR Acharya 2003 Crystal structure of the human angiotensin-converting enzyme-lisinopril complex Nature 421 551 554 10.1038/nature01370
25. MA Ondetti B Rubin DW Cushman 1977 Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents Science 196 441 444 10.1126/science.191908
26. K Patel A Kumar S Durani 2007 Analysis of the structural consensus of the zinc coordination centers of metalloprotein structures Biochim Biophys Acta 1774 1247 1253
27. AS Prasad AR Schulert A Miale Jr Z Farid HH Sandstead 1963 Zinc and iron deficiencies in male subjects with dwarfism and hypogonadism but without ancylostomiasis, schistosomiasis or severe anemia Am J Clin Nutr 12 437 444
28. J Raulin 1869 Etudes cliniques sur la vegetation Ann Sci Bot Biol Veg 11 93
29. Sillen LG, Martell AE (1971) Stability constants of metal-ion complexes. The Chemical Society, London, pp 250-281
30. EB Springman EL Angleton H Birkedal-Hansen HE Van Wart 1990 Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation Proc Natl Acad Sci USA 87 364 368 10.1073/pnas.87.1.364
31. P Towler B Staker SG Prasad S Menon J Tang T Parsons D Ryan M Fisher D Williams NA Dales MA Patane MW Pantoliano 2004 ACE2 structures reveal a large hinge-bending motion important for inhibitor binding and catalysis J Biol Chem 279 17996 18007 10.1074/jbc.M311191200
32. 2O of zinc enzymes Proc Natl Acad Sci USA 87 220 224 10.1073/pnas.87.1.220
33. BL Vallee DS Auld 1990 Zinc coordination, function, and structure of zinc enzymes and other proteins Biochemistry 29 5647 5659 10.1021/bi00476a001
34. BL Vallee DS Auld 1993 New perspective on zinc biochemistry: cocatalytic sites in multi-zinc enzymes Biochemistry 32 6493 6500 10.1021/bi00077a001
35. M Vasak JHR Kagi 1983 Spectroscopic properties of metallothionein Metal Ions Biol Syst 16 213 273