Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents

BioMetals

Volumn 22, Issue 1, 2009, Pages 61-75

  Miller, Marvin J ^a   Zhu, Helen ^a   Xu, Yanping ^a   Wu, Chunrui ^a   Walz, Andrew J ^a   Vergne, Anne ^a   Roosenberg, John M ^a   Moraski, Garrett ^a   Minnick, Albert A ^a   McKee Dolence, Julia ^a   Hu, Jingdan ^a   Fennell, Kelley ^a   Kurt Dolence, E ^a   Dong, Li ^a   Franzblau, Scott ^b   Malouin, Francois ^c   Möllmann, Ute ^d  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

^d HANS KNÖLL INSTITUTE   (Germany)

Author keywords

Antibiotics; Anticancer agents; Antituberculosis agents; Drug conjugates; Mycobactins; Siderophores

Indexed keywords

3 [(1 CARBOXYMETHYL 1H TETRAZOL 5 YL)THIOMETHYL] 7 [2 (6,7 DIHYDROXY 4 OXO 4H 1 BENZOPYRAN 3 CARBOXAMIDO) 2 (4 HYDROXYPHENYL)ACETAMIDO] 8 OXO 5 THIA 1 AZABICYCLO[4.2.0]OCT 2 ENE 2 CARBOXYLIC ACID; AMAMISTATIN A; AMAMISTATIN B; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; BE 32030; BETA LACTAMASE; CYCLOSPORIN DERIVATIVE; DEFEROXAMINE; DESFERRICARBOXYMYCOBACTIN DERIVATIVE; FORMOBACTIN; GRISEIN; IRON CHELATING AGENT; JH II 122; LB 10522; MYCOBACTIN; MYCOBACTIN M; MYCOBACTIN S; MYCOBACTIN T; NOCARDIMICIN A; NOCARDIMICIN B; NOCOBACTIN; OUTER MEMBRANE PROTEIN; SALMYCIN A; SALMYCIN B; SALMYCIN C; SALMYCIN D; SIDEROPHORE; TP A 0674; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; YPX I 145;

ACTIVE TRANSPORT; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; BACTERIAL VIRULENCE; BINDING SITE; CONFERENCE PAPER; DRUG DELIVERY SYSTEM; DRUG MANUFACTURE; DRUG RELEASE; DRUG RESEARCH; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; IRON METABOLISM; IRON TRANSPORT; LIPOPHILICITY; MICROBIAL METABOLISM; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR RECOGNITION; NONHUMAN; OXIDATIVE STRESS; REDUCTION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; ANTITUBERCULAR AGENTS; BACTERIA; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG RESISTANCE, MICROBIAL; HUMANS; IRON; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NEOPLASMS; OXAZOLES; SIDEROPHORES;

EQUIDAE;

EID: 59449105814     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-008-9185-0     Document Type: Conference Paper

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