The effects of capsaicin on gastrin secretion in isolated human antral glands: Before and after ingestion of red chilli

Digestive Diseases and Sciences

Volumn 54, Issue 3, 2009, Pages 491-498

  Ericson, A ^a   Nur, E Mohammed ^a   Petersson, F ^b   Kechagias, S ^c  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Capsaicin; Gastric hormone release; Gastrin cells; Immunohistochemistry; Radioimmunoassay

Indexed keywords

BUFFER; CAPSAICIN; GASTRIN; SEROTONIN; SOMATOSTATIN; VANILLOID RECEPTOR 1;

ADULT; ARTICLE; CONTROLLED STUDY; ENDOCRINE CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GASTRIN BLOOD LEVEL; GASTRIN CELL; GASTRIN RELEASE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; INGESTION; MALE; MICROSCOPY; NORMAL HUMAN; PEPPER; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RADIOIMMUNOASSAY; SEROTONIN BLOOD LEVEL; SOMATOSTATIN BLOOD LEVEL; STOMACH ANTRUM; STOMACH BIOPSY; STOMACH GLAND;

ADULT; CAPSAICIN; CAPSICUM; DIET; FEMALE; GASTRIC MUCOSA; GASTRINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PYLORIC ANTRUM; SEROTONIN; SOMATOSTATIN; TRPV CATION CHANNELS; YOUNG ADULT;

EID: 59449088166     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-008-0400-1     Document Type: Article

References (43)

1. P Holzer 1991 Capsaicin: cellular targets, mechanism of action, and selectivity for thin sensory neurons Pharmacol Rev 43 143 201
2. MJ Caterina 1997 The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature 389 816 824
3. A Szallasi PM Blumberg 1999 Vanilloid (Capsaicin) receptors and mechanisms Pharmacol Rev 51 159 211
4. P Holzer 1988 Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides Neuroscience 24 739 768
5. DE Clapham 2003 TRP channels as cellular sensors Nature 426 517 524
6. Benham CD, Gunthorpe MJ, Davis JB (2003) TRPV channels as temperature sensors. Cell Calcium 33:479-487
7. A Debreceni 1999 Caspsaicin increases gastric emptying rate in healthy human subjects measured by 13C-labeled octanoic acid breath test J Physiol Paris 93 455 460
8. R Gonzalez 1998 Effect of capsaicin-containing red pepper sauce suspension on upper gastrointestinal motility in healthy volunteers Dig Dis Sci 43 1165 1171
9. H Uno 1997 Involvement of capsaicin-sensitive sensory nerves in gastric adaptive relaxation in isolated guinea-pig stomachs Digestion 58 232 239
10. C Shibata 2002 Intraileal capsaicin inhibits gastrointestinal contractions via a neural reflex in conscious dogs Gastroenterology 123 1904 1911
11. JY Kang CH Teng FC och Chen 1995 The effects of capsaicin and chili on ethanol-induced gastric mucosal injury in the rat Gut 36 664 669
12. KG Yeoh 1995 Chili protects against aspirin-induced gastroduodenal mucosal injury in humans Dig Dis Sci 40 580 583
13. S Horie 2004 Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats Scand J Gastroenterol 39 303 312
14. M Tominaga 1998 The cloned capsaicin receptor integrates multiple pain-producing stimuli Neuron 21 531 543
15. Y Nozawa 2001 Distribution and characterization of vanilloid receptors in the rat stomach Neurosci Lett 309 33 36
16. B Veronesi 1999 Particulate matter initiates inflammatory cytokine release by activation of capsaicin and acid receptors in a human bronchial epithelial cell line Toxicol Appl Pharmacol 154 106 115
17. K Inoue 2002 Functional vanilloid receptors in cultured normal human epidermal keratinocytes Biochem Biophys Res Commun 291 124 129
18. S Stander 2005 Stimulation of keratinocyte differentiation-a new role for the vanilloid receptor subtype 1 (VR1/TRPV1)? Exp Dermatol 14 155
19. S Ständer 2004 Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures Exp Dermatol 13 129
20. Y Zhang 2006 Expression and characteristics of vanilloid receptor 1 in the rabbit submandibular gland Biochem Biophys Res Commun 345 467 473
21. S Kato 2003 Expression of vanilloid receptors in rat gastric epithelial cells: role in cellular protection Biochem Pharmacol 66 1115 1121
22. S Kechagias 2005 Expression of vanilloid receptor-1 in epithelial cells of human antral gastric mucosa Scand J Gastroenterol 40 775 782
23. C Bordi 2000 Classifiaction of gastric endocrine cells at the light and electron microscopic level.Micr Microsc Res Tech 48 258 271
24. MA Tzaneva 2003 Ultrastructural immunohistochemical localization of gastrin, somatostatin and serotonin in endocrine cells of human antral gastric mucosa Acta Histochem 105 191 201
25. T Berglindh KJ Obrink 1976 A method for preparing isolated glands from the rabbit gastric mucosa Acta Physiol Scand 96 150 159
26. MK Agarwal 2002 Effect of red chillies on small boweland colonic transit and rectal sensitivity in men with irritable bowel syndrome Ind J Gastroenterol 21 179 182
27. MF Dixon 1996 Classification, grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994 Am J Surg Pathol 20 1161 1181
28. M-S Faussone-Pelligrini 1995 Distribution of the vanilloid (capsaicin) receptor type 1 in the human stomach Histochem Cell Biol 124 61 68
29. SH Buck TS Burks 1986 The neuropharmacology of capsaicin: a review of some recent observations Pharmacol Rev 38 179 226
30. LA Birder 2001 Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells Proc Natl Acad Sci USA 98 13396 13400
31. P Holzer 1991 Sensory neurons mediate protective vasodilation in rat gastric mucosa Am J Physiol 260 G363 370
32. IT Lippe MA Pabst P och Holzer 1989 Intragastric capsaicin enhances rat gastric acid elimination and mucosal blood flow by afferent nerve stimulation Br J Pharmacol 96 91 100
33. K Takeuchi 1993 Regulation of gastroduodenal bicarbonate sevretion by capsaicin-sensitive sensory neurons in rats J Clin Gastroenterol 17 Suppl 33 39
34. FD Manela 1995 Calcitonin gene-related peptide modulates acid-mediated regulation of somatostatin and gastrin release from rat antrum Gastroenterology 109 701 706
35. OM Abdel-Salam 1999 Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents J Physiol (Paris) 93 443 454
36. P Holzer 2007 Taste receptors in the gastrointestinal tract. V, Acid sensing in the gastrointestinal tract Am J Physiol Gastrointest Liver Physiol 292 699 705
37. Yamada T, Chiba T (1989) Somatostatin. In: Schultz ST, Makhlouf GM (eds) Handbook of physiology: the gastrointestinal system II. Oxford University Press, Oxford, pp 431-453
38. E Fellenius 1983 A micro-method for the study of acid secretory function in isolated human oxyntic glands from gastroscopic biopsies Clin Sci (Lond) 64 423 431
39. A Berg 2004 Nitric oxide-an endogenous inhibitor of gastric acid secretion in isolated human gastric glands BMC Gastroenterol 4 16
40. SM Carlton 2004 Somatostatin modulates the transient receptor potential vanilloid 1 (TRPV1) ion channel Pain 110 616 627
41. OME Abdel-Salam J Szolcsanyi G och Mozsik 1997 Capsaicin and the stomach. A review of experimental and clinical data J Physiol Paris 91 151 171
42. MN Satyanarayana 2006 Capsaicin and gastric ulcers Crit Rev Food Sci Nutr 46 275 328
43. AS Piper JC Yeats S Bevan RJ och Docherty 1999 A study of the voltage dependence of capsaicin-activated membrane currents in rat sensory neurones before and after acute desensitization J Physiol 518 721 733