The human major histocompatibility complex and childhood leukemia: An etiological hypothesis based on molecular mimicry

Blood Cells, Molecules, and Diseases

Volumn 42, Issue 2, 2009, Pages 129-135

  Taylor, Malcolm ^a   Hussain, Adiba ^a   Urayama, Kevin ^b   Chokkalingam, Anand ^b   Thompson, Pamela ^a   Trachtenberg, Elizabeth ^c   Buffler, Patricia ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

Childhood leukaemia; Etiology; HLA; MHC mapping; Molecular mimicry; Reverse immunogenetics

Indexed keywords

HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN;

ADAPTIVE IMMUNITY; AUTOIMMUNE DISEASE; CASE CONTROL STUDY; CELL SURFACE; CHILDHOOD LEUKEMIA; CHROMOSOME 6; DNA POLYMORPHISM; GENE CLUSTER; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; HAPLOTYPE; HUMAN; IMMUNE RESPONSE; IMMUNOGENETICS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR MIMICRY; MOLECULAR TYPING; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ACUTE DISEASE; ADOLESCENT; ALLELES; ANTIGEN PRESENTATION; AUTOIMMUNE DISEASES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; ENVIRONMENTAL EXPOSURE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; INFECTION; LEUKEMIA; LINKAGE DISEQUILIBRIUM; MAJOR HISTOCOMPATIBILITY COMPLEX; MODELS, BIOLOGICAL; MOLECULAR MIMICRY; MYELOPOIESIS; POLYMORPHISM, GENETIC; PRELEUKEMIA;

EID: 59349108575     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2008.10.009     Document Type: Review

References (62)

1. Smith M., Ries L., Gurney J., and Ross J. Leukemia. In: Ries L., Smith M., Gurney J., Linet M., Tamra T., Young J., and Bunin G. (Eds). Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995 (1999), National Cancer Institute, SEER Program, Bethesda, MD 17-34
2. Steliarova-Foucher E., Stiller C., Kaatsch P., Berrino F., et al. Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCISproject): an epidemiological study. Lancet 364 (2004) 2097-2105
3. Greaves M.F., Colman S.M., Beard M.E., Bradstock K., et al. Geographical distribution of acute lymphoblastic leukaemia subtypes: second report of the collaborative group study. Leukemia 7 (1993) 27-34
4. Greaves M.F., and Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat. Rev., Cancer 3 (2003) 639-649
5. Greaves M. Infection, immune responses and the aetiology of childhood leukaemia. Nat. Rev. Cancer 6 (2006) 193-203
6. McNally R.J., and Eden T.O. An infectious aetiology for childhood acute leukaemia: a review of the evidence. Br. J. Haematol. 127 (2004) 243-263
7. O'Connor S.M., and Boneva R.S. Infectious etiologies of childhood leukemia: plausibility and challenges to proof. Environ. Health Perspect. 115 (2007) 146-150
8. Mori H., Colman S.M., Xiao Z., Ford A.M., et al. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 8242-8247
9. Ravetto P.F., Agarwal R., Chiswick M.L., D'Souza S.W., et al. Absence of leukaemic fusion gene transcripts in preterm infants exposed to diagnostic X rays. Arch. Dis. Child. Fetal Neonatal Ed. 88 (2003) F237-244
10. Horton R., Wilming L., Rand V., Lovering R.C., et al. Gene map of the extended human MHC. Nat. Rev. Genet. 5 (2004) 889-899
11. Madden D.R. The three-dimensional structure of peptide-MHC complexes. Annu. Rev. Immunol. 13 (1995) 587-622
12. Trowsdale J. HLA genomics in the third millennium. Curr. Opin. Immunol. 17 (2005) 498-504
13. Sette A., and Sidney J. HLA supertypes and supermotifs: a functional perspective on HLA polymorphism. Curr. Opin. Immunol. 10 (1998) 478-482
14. Hammer J., Sturniolo T., and Sinigaglia F. HLA class II peptide binding specificity and autoimmunity. Adv. Immunol. 66 (1997) 67-100
15. Christen U., and von Herrath M.G. Initiation of autoimmunity. Curr. Opin. Immunol. 16 (2004) 759-767
16. Klein J. Genetic control of virus susceptibility. Chapter 16. Biology of the Mouse Histocompatibility-2 Complex (1975), Springer-Verlag, Berlin 389-410
17. Lilly F., Boyse E.A., and Old L.J. Genetic basis of susceptibility to viral leukaemogenesis. Lancet 2 (1964) 1207-1209
18. Harris R., Lawler S.D., and Oliver R.T. The HLA system in acute leukaemia and Hodgkin's disease. Br. Med. Bull. 34 (1978) 301-304
19. Casper J.T., Marrari M., Piaskowski V., Lauer S.J., et al. Association between HLA-D region antigens and disease-free survival in childhood non-T, non-B acute lymphocytic leukemia. Blood 60 (1982) 698-702
20. Petersdorf E.W., Anasetti C., Martin P.J., and Hansen J.A. Tissue typing in support of unrelated hematopoietic cell transplantation. Tissue Antigens 61 (2003) 1-11
21. de Bakker P.I., McVean G., Sabeti P.C., Miretti M.M., et al. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat. Genet. 38 (2006) 1166-1172
22. Nejentsev S., Howson J.M., Walker N.M., Szeszko J., et al. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450 (2007) 887-892
23. Lincoln M.R., Montpetit A., Cader M.Z., Saarela J., et al. A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat. Genet. 37 (2005) 1108-1112
24. Miretti M.M., Walsh E.C., Ke X., Delgado M., et al. A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms. Am. J. Hum. Genet. 76 (2005) 634-646
25. Yunis E.J., Larsen C.E., Fernandez-Vina M., Awdeh Z.L., et al. Inheritable variable sizes of DNA stretches in the human MHC: conserved extended haplotypes and their fragments or blocks. Tissue Antigens 62 (2003) 1-20
26. UK Childhood Cancer Study Investigators. The United Kingdom Childhood Cancer Study: objectives, materials and methods. Br. J. Cancer 82 (2000) 1073-1102
27. Gardner M.J., Snee M.P., Hall A.J., Powell C.A., et al. Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ 300 (1990) 423-429
28. Chang J.S., Selvin S., Metayer C., Crouse V., et al. Parental smoking and the risk of childhood leukemia. Am. J. Epidemiol. 163 (2006) 1091-1100
29. Davies M.N., and Flower D.R. Harnessing bioinformatics to discover new vaccines. Drug Discov. Today 12 (2007) 389-395
30. De Groot A.S., and Berzofsky J.A. From genome to vaccine-new immunoinformatics tools for vaccine design. Methods 34 (2004) 425-428
31. Bian H., and Hammer J. Discovery of promiscuous HLA-II-restricted T cell epitopes with TEPITOPE. Methods 34 (2004) 468-475
32. Taylor G.M., Dearden S., Ravetto P., Ayres M., et al. Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201. Hum. Mol. Genet. 11 (2002) 1585-1597
33. Taylor G.M., Hussain A., Lightfoot T.J., Birch J.M., et al. HLA-associated susceptibility to childhood B-cell precursor ALL: definition and role of HLA-DPB1 supertypes. Br. J. Cancer 98 (2008) 1125-1131
34. Taylor M., Harrison C., Eden T., Birch J., et al. HLA-DPB1 supertype-associated protection from childhood leukaemia: relationship to leukaemia karyotype and implications for prevention. Cancer Immunol. Immunother. 57 (2008) 53-61
35. Kalish R.A., Leong J.M., and Steere A.C. Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi. Infect. Immun. 61 (1993) 2774-2779
36. Gross D.M., Forsthuber T., Tary-Lehmann M., Etling C., et al. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 281 (1998) 703-706
37. Steere A.C., Falk B., Drouin E.E., Baxter-Lowe L.A., et al. Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis. Arthritis Rheum. 48 (2003) 534-540
38. Trollmo C., Meyer A.L., Steere A.C., Hafler D.A., et al. Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells. J. Immunol. 166 (2001) 5286-5291
39. Diaz G., Canas B., Vazquez J., Nombela C., et al. Characterization of natural peptide ligands from HLA-DP2: new insights into HLA-DP peptide-binding motifs. Immunogenetics 56 (2005) 754-759
40. Dsouza M., Larsen N., and Overbeek R. Searching for patterns in genomic data. Trends Genet. 13 (1997) 497-498
41. Bairoch A., Boeckmann B., Ferro S., and Gasteiger E. Swiss-Prot: juggling between evolution and stability. Brief Bioinform. 5 (2004) 39-55
42. Jones T.R., Wiertz E.J., Sun L., Fish K.N., et al. Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 11327-11333
43. Komatsu H., Inui A., Sogo T., Fujisawa T., et al. Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responses. Immun. Ageing 3 (2006) 11
44. Altschul S.F., Madden T.L., Schaffer A.A., Zhang J., et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25 (1997) 3389-3402
45. Briesewitz R., Epstein M.R., and Marcantonio E.E. Expression of native and truncated forms of the human integrin alpha 1 subunit. J. Biol. Chem. 268 (1993) 2989-2996
46. Hynes R.O. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69 (1992) 11-25
47. Deschaseaux F., and Charbord P. Human marrow stromal precursors are alpha 1 integrin subunit-positive. J. Cell. Physiol. 184 (2000) 319-325
48. Moreau I., Duvert V., Caux C., Galmiche M.C., et al. Myofibroblastic stromal cells isolated from human bone marrow induce the proliferation of both early myeloid and B-lymphoid cells. Blood 82 (1993) 2396-2405
49. Renard N., Duvert V., Blanchard D., Banchereau J., et al. Activated CD4+ T cells induce CD40-dependent proliferation of human B cell precursors. J. Immunol. 152 (1994) 1693-1701
50. Misko I.S., Cross S.M., Khanna R., Elliott S.L., et al. Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: implications for molecular mimicry in autoimmune disease. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 2279-2284
51. Geijtenbeek T.B., van Kooyk Y., van Vliet S.J., Renes M.H., et al. High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia. Blood 94 (1999) 754-764
52. Liesveld J.L., Winslow J.M., Frediani K.E., Ryan D.H., et al. Expression of integrins and examination of their adhesive function in normal and leukemic hematopoietic cells. Blood 81 (1993) 112-121
53. Manabe A., Murti K.G., Coustan-Smith E., Kumagai M., et al. Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells. Blood 83 (1994) 758-766
54. Wall J.D., and Pritchard J.K. Haplotype blocks and linkage disequilibrium in the human genome. Nat. Rev. Genet. 4 (2003) 587-597
55. Fernando M.M., Stevens C.R., Sabeti P.C., Walsh E.C., et al. Identification of two independent risk factors for lupus within the MHC in United Kingdom families. PLoS Genet. 3 (2007) e192
56. A. Oliphant, D.L. Barker, J.R. Stuelpnagel, M.S. Chee, BeadArray technology: enabling an accurate, cost-effective approach to high-throughput genotyping, Biotechniques Suppl (2002) 56-58, 60-51.
57. Freedman M.L., Reich D., Penney K.L., McDonald G.J., et al. Assessing the impact of population stratification on genetic association studies. Nat. Genet. 36 (2004) 388-393
58. Framework for a fully powered risk engine. Nat. Genet. 37 (2005) 1153
59. Thomas D.C., and Witte J.S. Point: population stratification: a problem for case-control studies of candidate-gene associations?. Cancer Epidemiol. Biomarkers Prev. 11 (2002) 505-512
60. Wacholder S., Rothman N., and Caporaso N. Counterpoint: bias from population stratification is not a major threat to the validity of conclusions from epidemiological studies of common polymorphisms and cancer. Cancer Epidemiol. Biomark. Prev. 11 (2002) 513-520
61. Ioannidis J.P., Boffetta P., Little J., O'Brien T.R., et al. Assessment of cumulative evidence on genetic associations: interim guidelines. Int. J. Epidemiol. 37 (2008) 120-132
62. Chanock S.J., Manolio T., Boehnke M., Boerwinkle E., et al. Replicating genotype-phenotype associations. Nature 447 (2007) 655-660