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Volumn 4, Issue 1, 2009, Pages

Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P53; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TRANSFERASE; ACYLTRANSFERASE; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; OSTERIX PROTEIN, MOUSE; SMAD PROTEIN; TRANSCRIPTION FACTOR;

EID: 59249101074     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004135     Document Type: Article
Times cited : (37)

References (39)
  • 1
    • 17144383676 scopus 로고    scopus 로고
    • Identifying genes that regulate bone remodeling as potential therapeutic targets
    • Krane SM (2005) Identifying genes that regulate bone remodeling as potential therapeutic targets. J Exp Med 201: 841-843.
    • (2005) J Exp Med , vol.201 , pp. 841-843
    • Krane, S.M.1
  • 2
    • 0028925088 scopus 로고
    • Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
    • Manolagas SC, Jilka RL (1995) Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332: 305-311.
    • (1995) N Engl J Med , vol.332 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 3
    • 13244267455 scopus 로고    scopus 로고
    • Osteoclast-derived activity in the coupling of bone formation to resorption
    • Martin TJ, Sims NA (2005) Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol Med 11: 76-81.
    • (2005) Trends Mol Med , vol.11 , pp. 76-81
    • Martin, T.J.1    Sims, N.A.2
  • 4
    • 0242668869 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, their antagonists, and the skeleton
    • Canalis E, Economides AN, Gazzerro E (2003) Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev 24: 218-235.
    • (2003) Endocr Rev , vol.24 , pp. 218-235
    • Canalis, E.1    Economides, A.N.2    Gazzerro, E.3
  • 5
    • 0041304833 scopus 로고    scopus 로고
    • Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics
    • Zaidi M, Blair HC, Moonga BS, Abe E, Huang CL (2003) Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics. J Bone Miner Res 18: 599-609.
    • (2003) J Bone Miner Res , vol.18 , pp. 599-609
    • Zaidi, M.1    Blair, H.C.2    Moonga, B.S.3    Abe, E.4    Huang, C.L.5
  • 6
    • 0036782072 scopus 로고    scopus 로고
    • Discoveries, drugs and skeletal disorders
    • Goltzman D (2002) Discoveries, drugs and skeletal disorders. Nat Rev Drug Discov 1: 784-796.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 784-796
    • Goltzman, D.1
  • 7
    • 0037673933 scopus 로고    scopus 로고
    • Control of osteoblast function and regulation of bone mass
    • Harada S, Rodan GA (2003) Control of osteoblast function and regulation of bone mass. Nature 423: 349-355.
    • (2003) Nature , vol.423 , pp. 349-355
    • Harada, S.1    Rodan, G.A.2
  • 8
    • 0034984151 scopus 로고    scopus 로고
    • Minireview: Transcriptional control of osteoblast differentiation
    • Karsenty G (2001) Minireview: transcriptional control of osteoblast differentiation. Endocrinology 142: 2731-2733.
    • (2001) Endocrinology , vol.142 , pp. 2731-2733
    • Karsenty, G.1
  • 10
    • 0036306768 scopus 로고    scopus 로고
    • Transcription factors in bone: Developmental and pathological aspects
    • Yang X, Karsenty G (2002) Transcription factors in bone: developmental and pathological aspects. Trends Mol Med 8: 340-345.
    • (2002) Trends Mol Med , vol.8 , pp. 340-345
    • Yang, X.1    Karsenty, G.2
  • 11
    • 0030690556 scopus 로고    scopus 로고
    • The missing bone
    • Rodan GA, Harada S (1997) The missing bone. Cell 89: 677-680.
    • (1997) Cell , vol.89 , pp. 677-680
    • Rodan, G.A.1    Harada, S.2
  • 12
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, et al. (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108: 17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5
  • 13
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89: 747-754.
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 14
    • 36849055594 scopus 로고    scopus 로고
    • Kaback LA, Soung dY, Naik A, Smith N, Schwarz EM, et al. (2008) Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification. J Cell Physiol 214: 173-182.
    • Kaback LA, Soung dY, Naik A, Smith N, Schwarz EM, et al. (2008) Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification. J Cell Physiol 214: 173-182.
  • 16
    • 29944437296 scopus 로고    scopus 로고
    • p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling
    • Wang X, Kua HY, Hu Y, Guo K, Zeng Q, et al. (2006) p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling. J Cell Biol 172: 115-125.
    • (2006) J Cell Biol , vol.172 , pp. 115-125
    • Wang, X.1    Kua, H.Y.2    Hu, Y.3    Guo, K.4    Zeng, Q.5
  • 17
    • 24744462930 scopus 로고    scopus 로고
    • BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways
    • Celil AB, Campbell PG (2005) BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. J Biol Chem 280: 31353-31359.
    • (2005) J Biol Chem , vol.280 , pp. 31353-31359
    • Celil, A.B.1    Campbell, P.G.2
  • 18
    • 42949101521 scopus 로고    scopus 로고
    • BMP-2 Induces Osterix Expression through Up-regulation of Dlx5 and Its Phosphorylation by p38
    • Ulsamer A, Ortuno MJ, Ruiz S, Susperregui AR, Osses N, et al. (2008) BMP-2 Induces Osterix Expression through Up-regulation of Dlx5 and Its Phosphorylation by p38. J Biol Chem 283: 3816-3826.
    • (2008) J Biol Chem , vol.283 , pp. 3816-3826
    • Ulsamer, A.1    Ortuno, M.J.2    Ruiz, S.3    Susperregui, A.R.4    Osses, N.5
  • 19
    • 33947427924 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase regulates osteoblast differentiation through osterix
    • Wang X, Goh CH, Li B (2007) p38 mitogen-activated protein kinase regulates osteoblast differentiation through osterix. Endocrinology 148: 1629-1637.
    • (2007) Endocrinology , vol.148 , pp. 1629-1637
    • Wang, X.1    Goh, C.H.2    Li, B.3
  • 20
    • 33646588049 scopus 로고    scopus 로고
    • Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways
    • Lu X, Gilbert L, He X, Rubin J, Nanes MS (2006) Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways. J Biol Chem 281: 6297-6306.
    • (2006) J Biol Chem , vol.281 , pp. 6297-6306
    • Lu, X.1    Gilbert, L.2    He, X.3    Rubin, J.4    Nanes, M.S.5
  • 21
    • 40449139405 scopus 로고    scopus 로고
    • Dimorphic effects of Notch signaling in bone homeostasis
    • Engin F, Yao Z, Yang T, Zhou G, Bertin T, et al. (2008) Dimorphic effects of Notch signaling in bone homeostasis. Nat Med 14: 299-305.
    • (2008) Nat Med , vol.14 , pp. 299-305
    • Engin, F.1    Yao, Z.2    Yang, T.3    Zhou, G.4    Bertin, T.5
  • 23
    • 3543099503 scopus 로고    scopus 로고
    • Palmitoylation of intracellular signaling proteins: Regulation and function
    • Smotrys JE, Linder ME (2004) Palmitoylation of intracellular signaling proteins: regulation and function. Annu Rev Biochem 73: 559-87, 559-587.
    • (2004) Annu Rev Biochem , vol.73 , Issue.559-587 , pp. 559-587
    • Smotrys, J.E.1    Linder, M.E.2
  • 24
    • 33845794047 scopus 로고    scopus 로고
    • Palmitoylation: Policing protein stability and traffic
    • Linder ME, Deschenes RJ (2007) Palmitoylation: policing protein stability and traffic. Nat Rev Mol Cell Biol 8: 74-84.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 74-84
    • Linder, M.E.1    Deschenes, R.J.2
  • 25
    • 34247590130 scopus 로고    scopus 로고
    • Palmitoylation of ligands, receptors, and intracellular signaling molecules
    • Resh MD (2006) Palmitoylation of ligands, receptors, and intracellular signaling molecules. Sci STKE 2006: re14.
    • (2006) Sci STKE 2006
    • Resh, M.D.1
  • 26
    • 33646830442 scopus 로고    scopus 로고
    • Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins
    • Ohno Y, Kihara A, Sano T, Igarashi Y (2006) Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Biochim Biophys Acta 1761: 474-483.
    • (2006) Biochim Biophys Acta , vol.1761 , pp. 474-483
    • Ohno, Y.1    Kihara, A.2    Sano, T.3    Igarashi, Y.4
  • 27
    • 0037047404 scopus 로고    scopus 로고
    • Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity
    • Li B, Cong F, Tan CP, Wang SX, Goff SP (2002) Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity. J Biol Chem 277: 28870-28876.
    • (2002) J Biol Chem , vol.277 , pp. 28870-28876
    • Li, B.1    Cong, F.2    Tan, C.P.3    Wang, S.X.4    Goff, S.P.5
  • 29
    • 33748958993 scopus 로고    scopus 로고
    • Use of analogs and inhibitors to study the functional significance of protein palmitoylation
    • Resh MD (2006) Use of analogs and inhibitors to study the functional significance of protein palmitoylation. Methods 40: 191-197.
    • (2006) Methods , vol.40 , pp. 191-197
    • Resh, M.D.1
  • 30
    • 8744224520 scopus 로고    scopus 로고
    • ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells
    • Yang X, Karsenty G (2004) ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells. J Biol Chem 279: 47109-47114.
    • (2004) J Biol Chem , vol.279 , pp. 47109-47114
    • Yang, X.1    Karsenty, G.2
  • 31
    • 33644879150 scopus 로고    scopus 로고
    • Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling
    • Lengner CJ, Steinman HA, Gagnon J, Smith TW, Henderson JE, et al. (2006) Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol 172: 909-921.
    • (2006) J Cell Biol , vol.172 , pp. 909-921
    • Lengner, C.J.1    Steinman, H.A.2    Gagnon, J.3    Smith, T.W.4    Henderson, J.E.5
  • 32
    • 33644910689 scopus 로고    scopus 로고
    • Skeletons in the p53 tumor suppressor closet: Genetic evidence that p53 blocks bone differentiation and development
    • Zambetti GP, Horwitz EM, Schipani E (2006) Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development. J Cell Biol 172: 795-797.
    • (2006) J Cell Biol , vol.172 , pp. 795-797
    • Zambetti, G.P.1    Horwitz, E.M.2    Schipani, E.3
  • 33
    • 0034091809 scopus 로고    scopus 로고
    • Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation
    • Li B, Boast S, de los SK, Schieren I, Quiroz M, et al. (2000) Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation. Nat Genet 24: 304-308.
    • (2000) Nat Genet , vol.24 , pp. 304-308
    • Li, B.1    Boast, S.2    de los, S.K.3    Schieren, I.4    Quiroz, M.5
  • 34
    • 33745618456 scopus 로고    scopus 로고
    • Atm-deficient mice: An osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis
    • Rasheed N, Wang X, Niu QT, Yeh J, Li B (2006) Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis. Hum Mol Genet 15: 1938-1948.
    • (2006) Hum Mol Genet , vol.15 , pp. 1938-1948
    • Rasheed, N.1    Wang, X.2    Niu, Q.T.3    Yeh, J.4    Li, B.5
  • 35
    • 0347860319 scopus 로고    scopus 로고
    • Function of bone morphogenetic protein signaling during mouse development
    • Mishina Y (2003) Function of bone morphogenetic protein signaling during mouse development. Front Biosci 8: d855-69.
    • (2003) Front Biosci , vol.8
    • Mishina, Y.1
  • 36
    • 3042778695 scopus 로고    scopus 로고
    • A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways
    • Zuzarte-Luis V, Montero JA, Rodriguez-Leon J, Merino R, Rodriguez-Rey JC, et al. (2004) A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways. Dev Biol 272: 39-52.
    • (2004) Dev Biol , vol.272 , pp. 39-52
    • Zuzarte-Luis, V.1    Montero, J.A.2    Rodriguez-Leon, J.3    Merino, R.4    Rodriguez-Rey, J.C.5
  • 37
    • 1942533517 scopus 로고    scopus 로고
    • BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways
    • Qi X, Li TG, Hao J, Hu J, Wang J, et al. (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A 101: 6027-6032.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 6027-6032
    • Qi, X.1    Li, T.G.2    Hao, J.3    Hu, J.4    Wang, J.5
  • 38
  • 39
    • 0346594337 scopus 로고    scopus 로고
    • Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction
    • Pera EM, Ikeda A, Eivers E, De Robertis EM (2003) Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev 17: 3023-3028.
    • (2003) Genes Dev , vol.17 , pp. 3023-3028
    • Pera, E.M.1    Ikeda, A.2    Eivers, E.3    De Robertis, E.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.