Identifying genes that regulate bone remodeling as potential therapeutic targets

Journal of Experimental Medicine

Volumn 201, Issue 6, 2005, Pages 841-843

  Krane, Stephen M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN; CAS INTERACTING ZINC FINGER PROTEIN; FRIZZLED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; SCLEROPROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; ZINC FINGER PROTEIN;

BONE MASS; BONE REMODELING; CELL DIFFERENTIATION; CELL FUNCTION; FRACTURE; GENE FUNCTION; GENE IDENTIFICATION; GENE TARGETING; HUMAN; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BONE REMODELING; BONE RESORPTION; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, KNOCKOUT; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; OSTEOPOROSIS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 17144383676     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20050354     Document Type: Review

References (24)

1. Rodan, G.A., L.G. Raisz, and J.P. Bilezikian. 2002. Pathophysiology of osteoporosis. In Principles of Bone Biology. J.P. Bilezikian, L.G. Raisz, and G.A. Rodan, editors. San Diego, Academic Press. 1275-1289.
2. Lanyon, L., and T. Skerry. 2001. Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis. J. Bone Miner. Res. 16:1937-1947.
3. Delmas, P.D. 2000. How does antiresorptive therapy decrease the risk of fracture in women with osteoporosis? Bone. 27:1-3.
4. Neer, R.M., C.D. Arnaud, J.R. Zanchetta, R. Prince, G.A. Gaich, J.Y. Reginster, A.B. Hodsman, E.F. Eriksen, S. Shalom, H.K. Genant, O. Wang, and B.H. Mitlak. 2001. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med. 344:1434-1441.
5. Morinobu, M., T. Nakamoto, K. Hino, K. Tsuji, Z.-J. Shen, K. Nakashima, A. Nifuji, H. Yamamoto, H. Hirai, and M. Noda. 2005. The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein-induced bone formation. J. Exp. Med. 201:961-970.
6. Karsenty, G., and E.F. Wagner. 2002. Reaching a genetic and molecular understanding of skeletal development. Dev. Cell. 2:389-406.
7. Karsenty, G. 2003. The complexities of skeletal biology. Nature. 423:316-318.
8. Nakashima, K., X. Zhou, G. Kunkel, Z. Zhang, J.M. Deng, R.R. Behringer, and B. de Crombrugghe. 2002. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 108:17-29.
9. He, X., M. Semenov, K. Tamai, and X. Zeng. 2004. LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: arrows point the way. Development. 131:1663-1677.
10. Gong, Y., R.B. Slee, N. Fukai, G. Rawadi, S. Roman-Roman, A.M. Reginato, H. Wang, T. Cundy, F.H. Glorieux, D. Lev, M. Zacharin, K. Oexle, J. Marcelin et al. 2001. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 107:513-523.
11. Kato, M., M.S. Patel, R. Levasseur, I. Lobov, B.H. Chang, D.A. Glass II, C. Hartmann, L. Li, T.H. Hwang, C. F. Brayton, R.A. Lang, G. Karsenty, and L. Chan. 2002. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 157:303-314.
12. Yang, X., K. Matsuda, P. Bialek, S. Jacquot, H.C. Masuoka, T. Schinke, L. Li, S. Brancorsini, P. Sassone-Corsi, T.M. Townes, et al. 2004. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 117:387-398.
13. Chen, D., M. Zhao, and G.R. Mundy. 2004. Bone morphogenetic proteins. Growth Factors. 22:233-241.
14. Mundy, G.R. 2002. Directions of drug discovery in osteoporosis. Annu. Rev. Med. 53:337-354.
15. Mbalaviele, G., S. Sheikh, J.P. Stains, V.S. Salazar, S.L. Cheng, D. Chen, and R. Civitelli. 2005. β-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation. J. Cell. Biochem. 94:403-418.
16. Boyden, L.M., J.M. Mao, J. Belsky, L. Mitzner, A. Farhi, M.A. Mitnick, D. Wu, K. Insogna, and R.P. Lifton. 2002. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346:1513-1521.
17. Guo, J., F.R. Bringhurst, and H.M. Kronenberg. 2004. α1 collagen promoter-directed overexpression of Dkk1 in mice causes dwarfism and very short limbs. J. Bone Miner. Res. 19:S6.
18. Elefteriou, F., S. Takeda, K. Ebihara, J. Magre, N. Patano, C.A. Kim, Y. Ogawa, X. Liu, S.M. Ware, W.J. Craigen, et al. 2004. Serum leptin level is a regulator of bone mass. Proc. Natl. Acad. Sci. USA. 101:3258-3263.
19. Teitelbaum, S.L., and P.P. Ross. 2003. Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 4:638-649.
20. Gori, F., L.C. Hofbauer, C.R. Dunstan, T.C. Spelsberg, S. Khosla, and B.L. Riggs. 2000. The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated. Endocrinology. 141:4768-4776.
21. Whyte, M.P., S.E. Obrecht, P.M. Finnegan, J.L. Jones, M.N. Podgornik, W.H. McAlister, and S. Mumm. 2002. Homozygous deletion of osteoprotegerin and juvenile Paget disease. N. Engl. J. Med. 347:175-184.
22. Nakamoto, T., T. Yamagata, R. Sakai, S. Ogawa, H. Honda, H. Ueno, N. Hirano, Y. Yazaki, and H. Hirai. 2000. CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases. Mol. Cell. Biol. 20:1649-1658.
23. Shen, Z.J., T. Nakamoto, K. Tsuji, A. Nifuji, K. Miyazono, T. Komori, H. Hirai, and M. Noda. 2002. Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts. J. Biol. Chem. 277:29840-29846.
24. Yoshida, Y., A. von Bubnoff, N. Ikematsu, I.L. Blitz, J.K. Tsuzuku, E.H. Yoshida, H. Umemori, K. Miyazono, T. Yamamoto, and K.W. Cho. 2003. Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling. Mech. Dev. 120:629-637.