Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice

Molecular Immunology

Volumn 46, Issue 5, 2009, Pages 969-977

  Scheikl, Tanja ^a   Reis, Bernhard ^b   Pfeffer, Klaus ^b   Holzmann, Bernhard ^a   Beer, Sandra ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Marginal zone B cells; Notch; T independent antibody response

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN SLY1; ALPHA4 INTEGRIN; B LYMPHOCYTE RECEPTOR; CHEMOKINE RECEPTOR; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; NOTCH RECEPTOR; PNEUMOCOCCUS POLYSACCHARIDE; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR HES 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL MATURATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE TARGETING; GROWTH REGULATION; IMMUNIZATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; LYMPHOID PROGENITOR CELL; MARGINAL ZONE B CELL; MOUSE; MOUSE MUTANT; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; HOMEODOMAIN PROTEINS; IMMUNOGLOBULIN M; INTEGRIN ALPHA4; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; MICE, MUTANT STRAINS; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, NOTCH; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS;

MUS;

EID: 59249101010     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.09.023     Document Type: Article

References (37)

1. Allman D., Srivastava B., and Lindsley R.C. Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells. Immunol. Rev. 197 (2004) 147-160
2. Ansel K.M., Ngo V.N., Hyman P.L., Luther S.A., Förster R., Sedgwick J.D., Browning J.L., Lipp M., and Cyster J.G. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406 (2000) 309-314
3. Artavanis-Tsakonas S., Rand M.D., and Lake R.J. Notch signaling: cell fate control and signal integration in development. Science 284 (1999) 770-776
4. Astoul E., Laurence A.D., Totty N., Beer S., Alexander D.R., and Cantrell D.A. Approaches to define antigen receptor induced serine kinase signal transduction pathways. J. Biol. Chem. 278 (2003) 9267-9275
5. Beer S., Scheikl T., Reis B., Hüser N., Pfeffer K., and Holzmann B. Impaired immune responses and prolonged allograft survival in Sly1 mutant mice. Mol. Cell. Biol. 25 (2005) 9646-9660
6. Beer S., Simins A.B., Schuster A., and Holzmann B. Molecular cloning and characterization of a novel SH3 protein (SLY) preferentially expressed in lymphoid cells. Biochim. Biophys. Acta 1520 (2001) 89-93
7. Beres T.M., Masui T., Swift G.H., Shi L., Henke R.M., and MacDonald R.J. PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian suppressor of hairless (RBP-J) or its paralogue, RBP-L. Mol. Cell. Biol. 26 (2006) 117-130
8. Bleul C.C., Schultze J.L., and Springer T.A. B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement. J. Exp. Med. 187 (1998) 753-762
9. Bray S.J. Notch signalling: a simple pathway becomes complex. Nat. Rev. Mol. Cell Biol. 7 (2006) 678-689
10. Cariappa A., Tang M., Parng C., Nebelitsky E., Carroll M., Georgopoulos K., and Pillai S. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity 14 (2001) 603-615
11. Dou S., Zeng X., Cortes P., Erdjument-Bromage H., Tempst P., Honjo T., and Vales L.D. The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor. Mol. Cell. Biol. 14 (1994) 3310-3319
12. Förster R., Mattis A.E., Kremmer E., Wolf E., Brem G., and Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87 (1996) 1037-1047
13. Francis S.A., Shen X., Young J.B., Kaul P., and Lerner D.J. Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood 107 (2006) 1627-1635
14. Fukui Y., Hashimoto O., Sanui T., Oono T., Koga H., Abe M., Inayoshi A., Noda M., Oike M., Shirai T., and Sasazuki T. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 412 (2001) 826-831
15. Garcia-Bernal D., Sotillo-Mallo E., Nombela-Arrieta C., Samaniego R., Fukui Y., Stein J.V., and Teixido J. DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin α4β1. J. Immunol. 177 (2006) 5215-5225
16. Girkontaite I., Missy K., Sakk V., Harenberg A., Tedford K., Pötzel T., Pfeffer K., and Fischer K.-D. Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Nat. Immunol. 2 (2001) 855-862
17. Guinamard R., Okigaki M., Schlessinger J., and Ravetch J.V. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in humoral immune responses. Nat. Immunol. 1 (2000) 31-36
18. Iso T., Kedes L., and Hamamori Y. Hes and HERP families: multiple effectors of the Notch signaling pathway. J. Cell Physiol. 194 (2003) 237-255
19. Jeurissen A., Wuyts M., Kasran A., Ramdien-Murli S., Boon L., Ceuppens J.L., and Bossuyt X. Essential role for CD40 ligand interactions in T lymphocyte-mediated modulation of the murine immune response to pneumococcal capsular polysaccharides. J. Immunol. 168 (2002) 2773-2781
20. Kannabiran C., Zeng X., and Vales L.D. The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression. Mol. Cell. Biol. 17 (1997) 1-9
21. Kraal G., Schornagel K., Streeter P.R., Holzmann B., and Butcher E.C. Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen. Am. J. Pathol. 147 (1995) 763-771
22. Kuroda K., Han H., Tani S., Tanigaki K., Tun T., Furukawa T., Taniguchi Y., Kurooka H., Hamada Y., Toyokuni S., and Honjo T. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity 18 (2003) 301-312
23. Lai E.C. Keeping of good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins. EMBO Rep. 3 (2002) 840-845
24. Lopes-Carvalho T., and Kearney J.F. Development and selection of marginal zone B cells. Immunol. Rev. 197 (2004) 192-205
25. Lu T.T., and Cyster J.G. Integrin-mediated long-term B cell retention in the splenic marginal zone. Science 297 (2002) 409-412
26. MacLennan I.C.M., Toellner K.-M., Cunningham A.F., Serre K., Sze D.M.Y., Zuniga E., Cook M.C., and Vinuesa C.G. Extrafollicular antibody response. Immunol. Rev. 194 (2003) 8-18
27. Nie Y., Waite J., Brewer F., Sunshine M.-J., Littman D.R., and Zou Y.-R. The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J. Exp. Med. 200 (2004) 1145-1156
28. Olave I., Reinberg D., and Vales L.D. The mammalian transcriptional repressor RBP-J (CBF1) targets TFIID and TFIIA to prevent activated transcription. Genes Dev. 12 (1998) 1621-1637
29. Pillai S., Cariappa A., and Moran S.T. Marginal zone B cells. Annu. Rev. Immunol. 23 (2005) 161-196
30. Plaisance S., vanden Berghe W., Boone E., Fiers W., and Haegeman G. Recombination signal sequence binding protein Jκ is constitutively bound to the NF-κB site of the interleukin-6 promoter and acts as a negative regulatory factor. Mol. Cell. Biol. 17 (1997) 3733-3743
31. Qiao F., and Bowie J.U. The many faces of SAM. SciSTKE 286 (2005) re7
32. Rolink A.G., Andersson J., and Melchers F. Molecular mechanisms guiding late stages of B-cell development. Immunol. Rev. 197 (2004) 41-50
33. Saito T., Chiba S., Ichikawa M., Kunisato A., Asai T., Shimizu K., Yamaguchi T., Yamamoto G., Seo S., Kumano K., Nakagami-Yamaguchi E., Hamada Y., Aizawa S., and Hirai H. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 18 (2003) 675-685
34. Semmrich M., Smith A., Feterowski C., Beer S., Engelhardt B., Busch D.H., Bartsch B., Laschinger M., Hogg N., Pfeffer K., and Holzmann B. Importance of integrin LFA-1 deactivation for the generation of immune responses. J. Exp. Med. 201 (2005) 1987-1998
35. Strauch U.G., Gosslar U., Lifka A., and Holzmann B. Distinct functions of integrins α4β7, α4β1, and αIELβ7 in lymphocyte recirculation and matrix adhesion. Top. Mol. Med. 1 (1995) 187
36. Tanigaki K., Han H., Yamamoto N., Tashiro K., Ikegawa M., Kuroda K., Suzuki A., Nakano T., and Honjo T. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat. Immunol. 3 (2002) 443-450
37. Tanigaki K., and Honjo T. Regulation of lymphocyte development by Notch signaling. Nat. Immunol. 8 (2007) 451-456