Gγ1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration

PLoS Genetics

Volumn 5, Issue 1, 2009, Pages

  Deshpande, Girish ^a   Godishala, Anuradha ^a   Schedl, Paul ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GERANYLGERANYL DIPHOSPHATE SYNTHETASE; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOPRENOID; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; SYNTHETASE; UNCLASSIFIED DRUG; WNT1 PROTEIN; DIMETHYLALLYLTRANSFERASE; DROSOPHILA PROTEIN; FARNESYL TRANS TRANSFERASE; G PROTEIN COUPLED RECEPTOR; HEDGEHOG PROTEIN, DROSOPHILA; MEVALONIC ACID; QUEMAO PROTEIN, DROSOPHILA; SMOOTHENED PROTEIN, DROSOPHILA; TERPENE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; GERM CELL; NONHUMAN; PHENOTYPE; PROTEIN LOCALIZATION; PROTEIN SECRETION; ANIMAL; CELL MOTION; CYTOLOGY; DROSOPHILA; FEMALE; FORELIMB; GENETICS; HISTOLOGY; MALE; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; PROTEIN PROCESSING; TRANSGENIC ANIMAL;

ERINACEIDAE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL MOVEMENT; DIMETHYLALLYLTRANSTRANSFERASE; DROSOPHILA; DROSOPHILA PROTEINS; FARNESYLTRANSTRANSFERASE; FEMALE; GERM CELLS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HEDGEHOG PROTEINS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; MALE; METABOLIC NETWORKS AND PATHWAYS; MEVALONIC ACID; MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, G-PROTEIN-COUPLED; TERPENES; WING;

EID: 59249084586     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000333     Document Type: Article

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