Lung development in the Holtzman rat is adversely affected by gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Toxicological Sciences

Volumn 107, Issue 2, 2009, Pages 498-511

  Kransler, Kevin M ^a   Mcgarrigle, Barbara P ^a   Swartz, Daniel D ^a   Olson, James R ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

2,3,7,8 tetrachlorodibenzo p dioxin; Ahr; Ahrr; Aryl Hydrocarbon receptor; Aryl hydrocarbon receptor repressor; Lung development; Morphometric analysis; Pressure volume curve; Respiratory mechanics; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BREATHING MECHANICS; CHEMICAL TERATOGENESIS; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; FEMALE; FETUS; GESTATIONAL AGE; IMMATURITY; IMMUNOHISTOCHEMISTRY; LUNG DEVELOPMENT; LUNG HYPOPLASIA; LUNG TOXICITY; LUNG WEIGHT; NEWBORN; NONHUMAN; PRENATAL EXPOSURE; PRESSURE VOLUME CURVE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALS; ANIMALS, NEWBORN; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP1A1; ENVIRONMENTAL POLLUTANTS; FEMALE; FETAL VIABILITY; GENE EXPRESSION; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; LUNG; ORGAN SIZE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; RESPIRATORY MECHANICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TETRACHLORODIBENZODIOXIN;

ANIMALIA; RATTUS;

EID: 59149089822     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn235     Document Type: Article

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