Inhibition of pituitary tumors in Rb mutant chimeras through E2f4 loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis

Oncogene

Volumn 28, Issue 4, 2009, Pages 500-508

  Parisi, T ^a   Bronson, R T ^b   Lees, J A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

E2f4; Neuroendocrine tumors; Rb; Urothelial cancer

Indexed keywords

TRANSCRIPTION FACTOR E2F;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; GENE LOSS; GENE MUTATION; HYPOPHYSIS TUMOR; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; UROTHELIUM;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; E2F4 TRANSCRIPTION FACTOR; LONGEVITY; MICE; MICE, KNOCKOUT; PITUITARY NEOPLASMS; RETINOBLASTOMA PROTEIN; URINARY BLADDER; URINARY BLADDER NEOPLASMS; UROTHELIUM;

ANIMALIA; MUS;

EID: 59149085687     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.406     Document Type: Article

References (32)

1. Clarke AR, Maandag ER, van Roon M, van der Lugt NM, van der Valk M, Hooper ML et al. (1992). Requirement for a functional Rb1 gene in murine development. Nature 359: 328-330.
2. Dannenberg JH, van Rossum A, Schuijff L, Te Riele H. (2000). Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev 14: 3051-3064.
3. DeGregori J, Leone G, Miron A, Jakoi L, Nevins JR. (1997). Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci USA 94: 7245-7250.
4. Dinney CP, McConkey DJ, Millikan RE, Wu X, Bar-Eli M, Adam L et al. (2004). Focus on bladder cancer. Cancer Cell 6: 111-116.
5. Du W, Pogoriler J. (2006). Retinoblastoma family genes. Oncogene 25: 5190-5200.
6. Dyson N. (1998). The regulation of E2F by pRB-family proteins. Genes Dev 12: 2245-2262.
7. Friedrich G, Soriano P. (1991). Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5: 1513-1523.
8. Gaubatz S, Lees JA, Lindeman GJ, Livingston DM. (2001). E2F4 is exported from the nucleus in a CRM1-dependent manner. Mol Cell Biol 21: 1384-1392.
9. Gaubatz S, Lindeman GJ, Ishida S, Jakoi L, Nevins JR, Livingston DM et al. (2000). E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell 6: 729-735.
10. Harbour JW, Dean DC. (2000). The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev 14: 2393-2409.
11. Huber K. (2006). The sympathoadrenal cell lineage: specification, diversification, and new perspectives. Dev Biol 298: 335-343.
12. Humbert PO, Rogers C, Ganiatsas S, Landsberg RL, Trimarchi JM, Dandapani S et al. (2000a). E2F4is essential for normal erythrocyte maturation and neonatal viability. Mol Cell 6: 281-291.
13. Humbert PO, Verona R, Trimarchi JM, Rogers C, Dandapani S, Lees JA. (2000b). E2f3 is critical for normal cellular proliferation. Genes Dev 14: 690-703.
14. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA. (1992). Effects of an Rb mutation in the mouse. Nature 359: 295-300.
15. Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA, Dynlacht BD. (2002). E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell 2: 463-472.
16. Meuwissen R, Linn SC, Linnoila RI, Zevenhoven J, Mooi WJ, Berns A. (2003). Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell 4: 181-189.
17. Moberg K, Starz MA, Lees JA. (1996). E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol Cell Biol 16: 1436-1449.
18. Parisi T, Yuan TL, Faust AM, Caron AM, Bronson R, Lees JA. (2007). Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues. Mol Cell Biol 27: 2283-2293.
19. Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ et al. (2002). E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev 16: 933-947.
20. Rempel RE, Saenz-Robles MT, Storms R, Morham S, Ishida S, Engel A et al. (2000). Loss of E2F4 activity leads to abnormal development of multiple cellular lineages. Mol Cell 6: 293-306.
21. Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA et al. (2002). E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev 16: 245-256.
22. Sage J, Mulligan GJ, Attardi LD, Miller A, Chen S, Williams B et al. (2000). Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev 14: 3037-3050.
23. Schulz WA. (2006). Understanding urothelial carcinoma through cancer pathways. Int J Cancer 119: 1513-1518.
24. Trimarchi JM, Lees JA. (2002). Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 3: 11-20.
25. Verona R, Moberg K, Estes S, Starz M, Vernon JP, Lees JA. (1997). E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol Cell Biol 17: 7268-7282.
26. Weinberg RA. (1995). The retinoblastoma protein and cell cycle control. Cell 81: 323-330.
27. Wikenheiser-Brokamp KA. (2006). Retinoblastoma family proteins: insights gained through genetic manipulation of mice. Cell Mol Life Sci 63: 767-780.
28. Williams BO, Schmitt EM, Remington L, Bronson RT, Albert DM, Weinberg RA et al. (1994). Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. Embo J 13: 4251-4259.
29. Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT et al. (2001). The E2F1-3 transcription factors are essential for cellular proliferation. Nature 414: 457-462.
30. Wu XR. (2005). Urothelial tumorigenesis: a tale of divergent pathways. Nat Rev Cancer 5: 713-725.
31. Zhang ZT, Pak J, Shapiro E, Sun TT, Wu XR. (1999). Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in situ and invasive transitional cell carcinoma. Cancer Res 59: 3512-3517.
32. Ziebold U, Lee EY, Bronson RT, Lees JA. (2003). E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. Mol Cell Biol 23: 6542-6552.