Actions of propofol on substantia gelatinosa neurones in rat spinal cord revealed by in vitro and in vivo patch-clamp recordings

European Journal of Neuroscience

Volumn 29, Issue 3, 2009, Pages 518-528

  Takazawa, Tomonori ^a,b   Furue, Hidemasa ^a   Nishikawa, Koichi ^b   Uta, Daisuke ^a   Takeshima, Kaori ^a   Goto, Fumio ^b   Yoshimura, Megumu ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Anaesthetic mechanisms; GABAA receptor; In vivo patch clamp; Spinal dorsal horn

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; GLYCINE RECEPTOR; PROPOFOL;

ACTION POTENTIAL; ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN NERVE CELL; BRAIN SLICE; BREATHING; CELL ACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EVOKED CORTICAL RESPONSE; GABAERGIC SYSTEM; IN VITRO STUDY; IN VIVO STUDY; INJECTION; MALE; MECHANICAL STIMULATION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SKIN; SPINAL CORD; SUBSTANTIA GELATINOSA; SYNAPSE; WHOLE CELL;

ANESTHETICS, INTRAVENOUS; ANIMALS; EXCITATORY POSTSYNAPTIC POTENTIALS; GAMMA-AMINOBUTYRIC ACID; INHIBITORY POSTSYNAPTIC POTENTIALS; MALE; NEURAL INHIBITION; NEURONS; NOCICEPTORS; ORGAN CULTURE TECHNIQUES; PAIN; PAIN MEASUREMENT; PATCH-CLAMP TECHNIQUES; PHYSICAL STIMULATION; PROPOFOL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SPINAL CORD; SUBSTANTIA GELATINOSA; SYNAPTIC TRANSMISSION;

EID: 59149085131     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2008.06607.x     Document Type: Article

References (43)

1. Antognini, J.F., Wang, X.W., Piercy, M. Carstens, E. (2000) Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goats. Can. J. Anaesth., 47, 273 279.
2. Bai, D., Zhu, G., Pennefather, P., Jackson, M.F., MacDonald, J.F. Orser, B.A. (2001) Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons. Mol. Pharmacol., 59, 814 824.
3. Bieda, M.C. MacIver, M.B. (2004) Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability. J. Neurophysiol., 92, 1658 1667.
4. Chen, C.L., Yang, Y.R. Chiu, T.H. (1999) Activation of rat locus coeruleus neuron GABA(A) receptors by propofol and its potentiation by pentobarbital or alphaxalone. Eur. J. Pharmacol., 386, 201 210.
5. Chery, N. de Koninck, Y. (1999) Junctional versus extrajunctional glycine and GABA(A) receptor-mediated IPSCs in identified lamina I neurons of the adult rat spinal cord. J. Neurosci., 19, 7342 7355.
6. Evans, R.H. Smith, D.A. (1982) Effect of urethane on synaptic and amino acid-induced excitation in isolated spinal cord preparations. Neuropharmacology, 21, 857 860.
7. Franks, N.P. (2006) Molecular targets underlying general anaesthesia. Br. J. Pharmacol., 147 (Suppl. 1 S72 S81.
8. Furue, H., Narikawa, K., Kumamoto, E. Yoshimura, M. (1999) Responsiveness of rat substantia gelatinosa neurones to mechanical but not thermal stimuli revealed by in vivo patch-clamp recording. J. Physiol., 521 (Pt 2 529 535.
9. Grasshoff, C. Antkowiak, B. (2004) Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets. Anesthesiology, 101, 1167 1176.
10. Gredell, J.A., Turnquist, P.A., MacIver, M.B. Pearce, R.A. (2004) Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro. Br. J. Anaesth., 93, 810 817.
11. Grudt, T.J. Henderson, G. (1998) Glycine and GABAA receptor-mediated synaptic transmission in rat substantia gelatinosa: inhibition by mu-opioid and GABAB agonists. J. Physiol., 507 (Pt 2 473 483.
12. Hemmings, H.C. Jr., Akabas, M.H., Goldstein, P.A., Trudell, J.R., Orser, B.A. Harrison, N.L. (2005) Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol. Sci., 26, 503 510.
13. + channel involved in neuroprotection and general anesthesia. EMBO J., 23, 2684 2695.
14. Ito, A., Kumamoto, E., Takeda, M., Shibata, K., Sagai, H. Yoshimura, M. (2000) Mechanisms for ovariectomy-induced hyperalgesia and its relief by calcitonin: participation of 5-HT1A-like receptor on C-afferent terminals in substantia gelatinosa of the rat spinal cord. J. Neurosci., 20, 6302 6308.
15. Kato, G., Yasaka, T., Katafuchi, T., Furue, H., Mizuno, M., Iwamoto, Y. Yoshimura, M. (2006) Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J. Neurosci., 26, 1787 1794.
16. Kawasaki, Y., Kumamoto, E., Furue, H. Yoshimura, M. (2003) Alpha 2 adrenoceptor-mediated presynaptic inhibition of primary afferent glutamatergic transmission in rat substantia gelatinosa neurons. Anesthesiology, 98, 682 689.
17. Kazama, T., Ikeda, K. Morita, K. (1997) Reduction by fentanyl of the Cp50 values of propofol and hemodynamic responses to various noxious stimuli. Anesthesiology, 87, 213 227.
18. Kitamura, A., Marszalec, W., Yeh, J.Z. Narahashi, T. (2003) Effects of halothane and propofol on excitatory and inhibitory synaptic transmission in rat cortical neurons. J. Pharmacol. Exp. Ther., 304, 162 171.
19. Labrakakis, C., Tong, C.K., Weissman, T., Torsney, C. MacDermott, A.B. (2003) Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat. J. Physiol., 549, 131 142.
20. Maggi, C.A. Meli, A. (1986) Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 1: general considerations. Experientia, 42, 109 114.
21. Matute, E., Rivera-Arconada, I. Lopez-Garcia, J.A. (2004) Effects of propofol and sevoflurane on the excitability of rat spinal motoneurones and nociceptive reflexes in vitro. Br. J. Anaesth., 93, 422 427.
22. Mazoit, J.X. Samii, K. (1999) Binding of propofol to blood components: implications for pharmacokinetics and for pharmacodynamics. Br. J. Clin. Pharmacol., 47, 35 42.
23. Millan, M.J. (2002) Descending control of pain. Prog. Neurobiol., 66, 355 474.
24. Nadeson, R. Goodchild, C.S. (1997) Antinociceptive properties of propofol: involvement of spinal cord gamma-aminobutyric acid(A) receptors. J. Pharmacol. Exp. Ther., 282, 1181 1186.
25. Nakatsuka, T., Park, J.S., Kumamoto, E., Tamaki, T. Yoshimura, M. (1999) Plastic changes in sensory inputs to rat substantia gelatinosa neurons following peripheral inflammation. Pain, 82, 39 47.
26. Narikawa, K., Furue, H., Kumamoto, E. Yoshimura, M. (2000) In vivo patch-clamp analysis of IPSCs evoked in rat substantia gelatinosa neurons by cutaneous mechanical stimulation. J. Neurophysiol., 84, 2171 2174.
27. Orser, B.A., Wang, L.Y., Pennefather, P.S. MacDonald, J.F. (1994) Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons. J. Neurosci., 14, 7747 7760.
28. Rudolph, U. Antkowiak, B. (2004) Molecular and neuronal substrates for general anaesthetics. Nat. Rev. Neurosci., 5, 709 720.
29. Sceniak, M.P. MacIver, M.B. (2006) Cellular actions of urethane on rat visual cortical neurons in vitro. J. Neurophysiol., 95, 3865 3874.
30. Shimizu, M., Yamakura, T., Tobita, T., Okamoto, M., Ataka, T., Fujihara, H., Taga, K., Shimoji, K. Baba, H. (2002) Propofol enhances GABA(A) receptor-mediated presynaptic inhibition in human spinal cord. Neuroreport, 13, 357 360.
31. Smith, C., McEwan, A.I., Jhaveri, R., Wilkinson, M., Goodman, D., Smith, L.R., Canada, A.T. Glass, P.S. (1994) The interaction of fentanyl on the Cp50 of propofol for loss of consciousness and skin incision. Anesthesiology, 81, 820 828.
32. Sonohata, M., Furue, H., Katafuchi, T., Yasaka, T., Doi, A., Kumamoto, E. Yoshimura, M. (2004) Actions of noradrenaline on substantia gelatinosa neurones in the rat spinal cord revealed by in vivo patch recording. J. Physiol., 555, 515 526.
33. Takahashi, A., Mashimo, T. Uchida, I. (2006) GABAergic tonic inhibition of substantia gelatinosa neurons in mouse spinal cord. Neuroreport, 17, 1331 1335.
34. Takizawa, D., Hiraoka, H., Goto, F., Yamamoto, K. Horiuchi, R. (2005) Human kidneys play an important role in the elimination of propofol. Anesthesiology, 102, 327 330.
35. Tan, P.P., Shyr, M.H., Yang, C.H., Kuo, T.B., Pan, W.H. Chan, S.H. (1993) Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: intravenous infusion. Neurosci. Lett., 160, 205 208.
36. Uchida, H., Kishikawa, K. Collins, J.G. (1995) Effect of propofol on spinal dorsal horn neurons. Comparison with lack of ketamine effects. Anesthesiology, 83, 1312 1322.
37. Wall, P.D., Merrill, E.G. Yaksh, T.L. (1979) Responses of single units in laminae 2 and 3 of cat spinal cord. Brain Res., 160, 245 260.
38. Wu, X.S., Sun, J.Y., Evers, A.S., Crowder, M. Wu, L.G. (2004) Isoflurane inhibits transmitter release and the presynaptic action potential. Anesthesiology, 100, 663 670.
39. Yang, C.H., Shyr, M.H., Kuo, T.B., Tan, P.P. Chan, S.H. (1995) Effects of propofol on nociceptive response and power spectra of electroencephalographic and systemic arterial pressure signals in the rat: correlation with plasma concentration. J. Pharmacol. Exp. Ther., 275, 1568 1574.
40. Ying, S.W., Abbas, S.Y., Harrison, N.L. Goldstein, P.A. (2006) Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons. Eur. J. Neurosci., 23, 465 480.
41. Yoshimura, M. Nishi, S. (1993) Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: pharmacological properties of synaptic currents. Neuroscience, 53, 519 526.
42. Yoshimura, M. Nishi, S. (1995) Primary afferent-evoked glycine- and GABA-mediated IPSPs in substantia gelatinosa neurones in the rat spinal cord in vitro. J. Physiol., 482 (Pt 1 29 38.
43. Zhang, Y., Laster, M.J., Hara, K., Harris, R.A., Eger, E.I., 2nd., Stabernack, C.R. Sonner, J.M. (2003) Glycine receptors mediate part of the immobility produced by inhaled anesthetics. Anesth. Analg., 96, 97 101.