Human kidneys play an important role in the elimination of propofol

Anesthesiology

Volumn 102, Issue 2, 2005, Pages 327-330

  Takizawa, Daisuke ^a   Hiraoka, Haruhiko ^a   Goto, Fumio ^a   Yamamoto, Koujirou ^a   Horiuchi, Ryuya ^a,b  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; NITROUS OXIDE; PROPOFOL; SEVOFLURANE; VECURONIUM;

4 AMINOHIPPURIC ACID CLEARANCE; ADULT; AGED; ANESTHESIA INDUCTION; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; CANNULA; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG INFUSION; FEMALE; HUMAN; IN VIVO STUDY; KIDNEY BLOOD FLOW; KIDNEY CLEARANCE; KIDNEY VEIN; LIVER CLEARANCE; MALE; NEPHRECTOMY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIAL ARTERY;

AGED; FEMALE; HUMANS; KIDNEY; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; PROPOFOL;

EID: 13244254125     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200502000-00014     Document Type: Article

References (24)

1. Simons PJ, Cockshott ID, Douglas EJ, Gordon EA, Hopkins K, Rowland M: Disposition in male volunteers of a subanaesthetic intravenous dose of an oil In water emulsion of 14C-propofol. Xenobiotica 1988; 18:429-40
2. Hiraoka H, Yamamoto K, Okano N, Morita T, Goto F, Horiuchi R: Changes in drug plasma concentrations of an extensively bound and highly extracted drug, propofol, in response to altered plasma binding. Clin Pharmacol Ther 2004; 75:324-30
3. Gepts WE, Camu H, Cocksott ID, Douglas EJ: Disposition of propofol administered as constant rate intravenous infusion in humans. Anesth Analg 1987; 66:1256-63
4. Veroli P, Okelly B, Bertrand F, Trouvin JH, Farinotti R, Ecoffey C: Extrahepatic metabolism of propofol in man during the anhepatic phase of orthotopic liver transplantation. Br J Anaesth 1992; 68:183-6
5. Kuipers JA, Boer F, Olieman W, Burm AG, Bovill JG: First-pass lung uptake and pulmonary clearance of propofol: Assessment with a recirculatory indocyanine green pharmacokinetic model. ANESTHESIOLOGY 1999; 91:1780-7
6. Matot I, Neely CF, Katz RY, Marshall BE: Fentanyl and propofol uptake by the lung: Effect of time between injections. Acta Anaesthesiol Scand 1994; 38:711-5
7. Matot I, Neely CF, Katz RY, Neufeld GR: Pulmonary uptake of propofol in cats: Effect of fentanyl and halothane. ANESTHESIOLOGY 1993; 78:1157-65
8. Dutta S, Ebling WF: Formulation-dependent brain and lung distribution kinetics of propofol in rats. ANESTHESIOLOGY 1998; 89:678-85
9. He YL, Ueyama H, Tashiro C, Mashimo T, Yoshiya I: Pulmonary disposition of propofol in surgical patients. ANESTHESIOLOGY 2000; 93:986-91
10. Dawidowicz AL, Fornal E, Mardarwicz M, Fijalkowska A: The role of human lungs in the biotransformation of propofol. ANESTHESIOLOGY 2000; 93:992-7
11. Favetta P, Degoute CS, Perdrix JP, Dufresne C, Boulieu R, Guitton J: Propofol metabolites in man following propofol induction and maintenance. Br J Anaesth 2002; 88:653-8
12. Zhang SH, Li Q, Yao SL, Zeng BX: Subcellular expression of UGT1A6 and CYP1A1 responsible for propofol metabolism in human brain. Acta Pharmacol Sin 2001; 22:1013-7
13. King CD, Rios GR, Assouline JA, Tephly TR: Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate. Arch Biochem Biophys 1999; 365:156-62
14. McGurk KA, Brierley CH, Burchell B: Drug glucuronidation by human renal UDP-glucuronosyltransferases. Biochem Pharmacol 1998; 55:1005-12
15. Soars MG, Riley RJ, Findlay KA, Coffey MJ, Burchell B. Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney. Drug Metab Dispos 2001; 29:121-6
16. Raoof AA, van Obbergh LJ, de Ville de Goyet J, Verbeeck RK: Extrahepatic glucuronidation of propofol in man: Possible contribution of gut wall and kidney. Eur J Clin Pharmacol 1996; 50:91-6
17. Brun C: Trisulfate determination in kidney function tests. J Lab Med 1950: 35:152-54
18. Adam HK, Briggs LP, Bahar M, Douglas EJ, Dundee JW: Pharmacokinetic evaluation of ICI 35 868 in man: Single induction doses with different rates of injection. Br J Anaesth 1983; 55:97-103
19. Cockshott ID, Briggs LP, Douglas EJ, White M: Pharmacokinetics of propofol in female patients: Studies using single bolus injections. Br J Anaesth 1987; 59:1103-10
20. Icks B, Cockshott ID, Barvais L, Byttebier G, DePauw L, Vandesteene A, D'Hollander AA: Propofol infusion for induction and maintenance of anaesthesia in patients with end-stage renal disease. Br Jr Anaesth 1998; 81:854-60
21. Servin F, Desmonts JM, Haberer JP, Cockshott ID, Plummer GF, Farinotti R: Pharmacokinetics and protein binding of propofol in patients with cirrhosis. ANESTHESIOLOGY 1988; 69:887-91
22. Knibbe CA, Zuideveld KP, Dejongh J, Kuks PF, Aarts LP, Danhof M: Population pharmacokinetics and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: a comparison between propofol 6% and propofol 1%. Clin Pharmacol Ther 2002; 72:670-84
23. Schuttler J, Ihmsen H: Population pharmacokinetics of propofol: A multi-center study. ANESTHESOLOGY 2000; 92:727-38
24. Shafer SL, Stanski DR: Improving the clinical utility of anesthetic drug pharmacokinetics. ANESTHESIOLOGY 1992; 76:327-30