Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs as sigma-2 receptor ligands

Medicinal Chemistry Research

Volumn 11, Issue 7, 2002, Pages 380-398

  Mach, Robert H ^a,c   Vangveravong, Suwanna ^a,b   Huang, Yunsheng ^a,b   Yang, Biao ^a,b   Blair, Joseph B ^a   Wu, Li ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b Anasazi Biomedical Research Inc   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 AZA BICYCLO[3.3.1]NONAN 3ALPHA YLPHENYLCARBAMATE DERIVATIVE; BICYCLO COMPOUND; CARBAMIC ACID DERIVATIVE; LIGAND; N [9 (4 AMINOPHENETHYL) 9 AZABICYCLO[3.3.1]NONAN 3ALPHA YL] N' (2 METHOXY 5 METHYLPHENYL)CARBAMATE; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0037765110     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Walker J.M., Bowen W.D., Walker F.O., Matsumoto R.E., De Costa B. and Rice K.R. Pharmacol. Rev. 1990, 42, 355-402.
2. Hellewell S.B., Bruce A., Feinstein G., Orringer J., Williams W. and Bowen, W.D. Eur. J. Pharmacol. Mol. Pharmacol. Sec. 1994, 268, 9-18.
3. Hanner M., Moebius F.F., Flandorfer A., Knaus H.-G., Striessnig J., Kempner E. and Glossmann H. Proc. Natl. Acad. Sci. USA 1996, 93, 8072-8077.
4. Su T.-P., London E. and Jaffe J. Science 1988, 240, 219-221.
5. Bowen W.D., Bertha C.M., Vilner B.J. and Rice K. Eur. J. Pharmacol. 1995, 278, 257-260.
6. Nguyen V.H., Kassiou M., Johnston G.A.R. and Christie M.J. Eur. J. Pharmacol. 1996, 311, 233-240.
7. Bowen W.D., Vilner B.J., Bertha C.M., Kuehne M.E. and Jocabson A.E. Eur. J. Pharmacol. 1995, 279, R1-3.
8. Mach R.H., Smith C.R. and Childers S.R. Life Sci. 1995, 57, PL 57-62.
9. Perredgaard J., Moltzen E.K., Meier E. and Sanchez C. J. Med. Chem. 1995, 38, 1998-2008.
10. Moltzen, E.K., Perregaard J. and Meier E. J. Med. Chem. 1995, 38, 2009-2017.
11. Bonhaus D.W., Loury D.N., Jakeman L.B., To Z., DeSouza A., Eglen R.M. and Wong E.H.F.J. Pharmacol. Exp. Ther. 1993, 267, 961-970.
12. Mach R.H., Yang B., Kuhner R.J., Whirrett B.R. and West T. Med. Chem. Res. 2001, 10, 339-355.
13. Mach R.H., Wheeler K.T., Blair S., Yang B., Day C.S., Blair J.B., Choi S.-R. and Kung H.F. J. Labelled Cmpds. Radiopharm. 2001, 44, 899-908.
14. Bradford M.M. Anal. Biochem. 1976, 72, 248-254.
15. Cheng Y.C. and Prusoff W.H. Biochem. Pharmacol. 1973, 22, 3099-4022.