Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands

Journal of Medicinal Chemistry

Volumn 48, Issue 1, 2005, Pages 266-273

  Costantino, Luca ^a   Gandolfi, Francesca ^a   Sorbi, Claudia ^a,d   Franchini, Silvia ^a   Prezzavento, Orazio ^b   Vittorio, Franco ^b   Ronsisvalle, Giuseppe ^b   Leonardi, Amedeo ^c   Poggesi, Elena ^c   Brasili, Livio ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c Recordati SpA   (Italy)

^d Eurand SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (1,2,3,4 TETRAHYDRONAPHTHYLMETHYL)] 4 BENZYLPIPERAZINE; 1 [2 (1,2,3,4 TETRAHYDRONAPHTHYLMETHYL)] 4 BENZYLPIPERIDINE; 1 BENZYL 4 (2,3 DIHYDROBENZO[1,4]DIOXIN 2 YLMETHYL)PIPERAZINE; 2 (4 BENZYLPIPERIDIN 1 YLMETHYL) 1 TETRALONE; 2 [(4' BENZYLPIPERAZINYL)METHYL]CHROMANE; 2 [(4' BENZYLPIPERAZINYL)METHYL]CHROMANONE; 2 [(4' BENZYLPIPERIDINYL)METHYL]CHROMANE; 2 [(4' BENZYLPIPERIDINYL)METHYL]CHROMANONE; 3 (4 BENZYLPIPERAZIN 1 YLMETHYL)1 TETRALONE; 3 (4 BENZYLPIPERIDIN 1 YLMETHYL)1 TETRALONE; 3 [(4 BENZYLPIPERAZINYL)METHYL]CHROMONE; 3 [(4 BENZYLPIPERIDINYL)METHYL]CHROMONE; 3 [(4' BENZYLPIPERAZINYL)METHYL]CHROMANE; 3 [(4' BENZYLPIPERIDINYL)METHYL]CHROMANE; 3 [(4' BENZYLPIPERIDINYL)METHYL]CHROMANONE; 4 BENZYL 1 (2,3 DIHYDROBENZO[1,4]DIOXIN 2 YLMETHYL)PIPERIDINE; 4 BENZYL 1 (5 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 2 YLMETHYL)PIPERIDINE; 4 BENZYL 1 (6 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 2 YLMETHYL)PIPERIDINE; 4 BENZYL 1 (6,7,8,9 TETRAHYDROBENZOCYCLOHEPTAN 6 YLMETHYL)PIPERIDINE; 4 BENZYL 1 (7 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 2 YLMETHYL)PIPERIDINE; 4 BENZYL 1 (8 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 2 YLMETHYL)PIPERIDINE; 4 BENZYL 1 OXO INDAN 2 YLMETHYLPIPERIDINE; 4 BENZYLINDAN 2 YLMETHYLPIPERIDINE; 6 (4 BENZYLPIPERIDIN 1 YLMETHYL) 6,7,8,9 TETRAHYDROBENZOCYCLOHEPTAN 5 ONE; DOPAMINE 2 RECEPTOR; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SIGMA 1 OPIATE RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; BIOCHEMISTRY; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; PIPERAZINES; PIPERIDINES; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, DOPAMINE D2; RECEPTORS, OPIOID; RECEPTORS, SIGMA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 19944427837     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049433t     Document Type: Article

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