FoxP3 positive T cells in graft biopsies from living donor kidney transplants after donor-specific transfusions

Transplantation

Volumn 87, Issue 1, 2009, Pages 138-142

  Eisenberger, Ute ^a   Seifried, Andrea ^a,c   Patey, Natacha ^b   Kappeler, Andreas ^c   Noel, Laure Hélène ^b   Frey, Felix J ^a   Körner, Meike ^c  

^a UNIVERSITY OF BERN   (Switzerland)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Acute rejection; Donor specific transfusions; FoxP3; Regulatory T cells; Renal allograft pathologic condition

Indexed keywords

CALCINEURIN INHIBITOR; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ADULT; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TRANSFUSION; UNSPECIFIED SIDE EFFECT; BIOPSY; BLOOD TRANSFUSION; IMMUNOLOGY; METABOLISM; T LYMPHOCYTE;

ADULT; BIOPSY; BLOOD TRANSFUSION; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GRAFT SURVIVAL; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY TRANSPLANTATION; LIVING DONORS; MALE; T-LYMPHOCYTES;

EID: 58949099248     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181900278     Document Type: Article

References (21)

1. Opelz G, Vanrenterghem Y, Kirste G, et al. Prospective evaluation of pretransplant blood transfusions in cadaver kidney recipients. Transplantation 1997; 63: 964.
2. Marti HP, Henschkowski J, Laux G, et al. Effect of donor-specific transfusions on the outcome of renal allografts in the cyclosporine era. Transpl Int 2006; 19: 19.
3. Cavinato RA, Casiraghi F, Azzollini N, et al. Pretransplant donor peripheral blood mononuclear cells infusion induces transplantation tolerance by generating regulatory T cells. Transplantation 2005; 79:1034.
4. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057.
5. Roncador G, Brown PJ, Maestre L, et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 2005; 35: 1681.
6. Veronese F, Rotman S, Smith RN, et al. Pathological and clinical correlates of FOXP3+ cells in renal allografts during acute rejection. Am J Transplant 2007; 7: 914.
7. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
8. Racusen LC, Colvin RB, Solez K, et al. Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003; 3: 708.
9. Nankivell BJ, Borrows RJ, Fung CL, et al. Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation 2004; 78: 557.
10. Tostivint I, du Montcel ST, Jaudon MC, et al. Renal outcome after ciclosporin-induced nephrotoxicity. Nephrol Dial Transplant 2007; 22: 880.
11. Campbell SB, Hothersall E, Preston J, et al. Frequency and severity of acute rejection in live- versus cadaveric-donor renal transplants. Transplantation 2003; 76: 1452.
12. Chkhotua AB, Klein T, Shabtai E, et al. Kidney transplantation from living-unrelated donors: Comparison of outcome with living-related and cadaveric transplants under current immunosuppressive protocols. Urology 2003; 62: 1002.
13. Krieger NR, Becker BN, Heisey DM, et al. Chronic allograft nephropathy uniformly affects recipients of cadaveric, nonidentical living-related, and living-unrelated grafts. Transplantation 2003; 75:1677.
14. Bushell A, Karim M, Kingsley CI, et al. Pretransplant blood transfusion without additional immunotherapy generates CD25 + CD4+ regulatory T cells: A potential explanation for the blood-transfusion effect. Transplantation 2003; 76: 449.
15. Quigley RL, Wood KJ, Morris PJ. Transfusion induces blood donor-specific suppressor cells. J Immunol 1989; 142: 463.
16. Zhang ZX, Yang L, Young KJ, et al. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med 2000; 6: 782.
17. Kingsley CI, Karim M, Bushell AR, et al. CD25 + CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immuno-regulation of alloresponses. J Immunol 2002; 168: 1080.
18. Jarvinen LZ, Blazar BR, Adeyi OA, et al. CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant tolerance. Transplantation 2003; 76: 1375.
19. Mantel PY, Ouaked N, Ruckert B, et al. Molecular mechanisms underlying FOXP3 induction in human T cells. J Immunol 2006; 176: 3593.
20. Muthukumar T, Dadhania D, Ding R, et al. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 2005; 353: 2342.
21. Bestard O, Cruzado JM, Rama I, et al. Presence of FoxP3 + regulatory T cells predicts outcome of subclinical rejections of renal allografts. J Am Soc Nephrol 2008; 19:2020.