Dual effect of Platelet Factor 4 on the activities of Factor Xa

Biochemical and Biophysical Research Communications

Volumn 379, Issue 4, 2009, Pages 1072-1075

  Fiore, Martine M ^a   Mackie, Ian J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Anticoagulation; Coagulation; Factor Va; Heparin; Platelet Factor 4; Prothrombin activation

Indexed keywords

BLOOD CLOTTING FACTOR 10A; HEPARIN; PROTHROMBIN; THROMBOCYTE FACTOR 4;

ALLOSTERISM; ARTICLE; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN INTERACTION;

ALLOSTERIC REGULATION; BLOOD COAGULATION; FACTOR XA; HEPARIN; HYDROLYSIS; OLIGOPEPTIDES; PLATELET FACTOR 4;

EID: 58949093365     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.01.016     Document Type: Article

References (19)

1. Nesheim M.E., Taswell J.B., and Mann K.G. The contribution of bovine Factor V and Factor Va to the activity of prothrombinase. J. Biol. Chem. 254 (1979) 10952-10962
2. Bukys M.A., Blum M.A., Kim P.Y., et al. Incorporation of Factor Va into prothrombinase is required for coordinated cleavage of prothrombin by Factor Xa. J. Biol. Chem. 280 (2005) 27391-27401
3. Walker R.K., and Krishnaswamy S. The influence of Factor Va on the active site of factor Xa. J. Biol. Chem. 268 (1993) 13920-13929
4. Krishnaswamy S., and Betz A. Exosites determine macromolecular substrate recognition by prothrombinase. Biochemistry 36 (1997) 12080-12086
5. Olson S.T., Swanson R., Raub-Segall E., et al. Accelerating ability of synthetic oligosaccharides on antithrombin inhibition of proteinases of the clotting and fibrinolytic systems: comparison with heparin and low-molecular-weight heparin. Thromb. Haemost. 92 (2004) 929-939
6. Rezaie A.R. Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by a template mechanism: evidence that calcium alleviates Gla domain antagonism of heparin binding to factor Xa. J. Biol. Chem. 273 (1998) 16824-16827
7. Rezaie A.R. Identification of basic residues in the heparin-binding exosite of factor Xa critical for heparin and factor Va binding. J. Biol. Chem. 275 (2000) 3320-3327
8. Shuman M.A., and Levine S.P. Relationship between secretion of Platelet Factor 4 and thrombin generation during in vitro blood clotting. J. Clin. Invest. 65 (1980) 307-313
9. Dehmer G.J., Fisher M., Tate D.A., Teo S., and Bonnem E.M. Reversal of heparin anticoagulation by recombinant platelet factor 4 in humans. Circulation 91 (1995) 2188-2194
10. Mixon T.A., and Dehmer G.J. Recombinant platelet factor 4 for heparin neutralization. Semin. Thromb. Haemost. 30 (2004) 369-377
11. Rauova L., Poncz M., McKenzie S.E., et al. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood 105 (2005) 131-138
12. Fiore M.M., and Kakkar V.V. Platelet Factor 4 neutralizes heparan sulphate-enhanced antithrombin inactivation of factor Xa by preventing interaction of enzyme with polysaccharide. Biochem. Biophys. Res. Commun. 311 (2003) 71-76
13. Denton J., Lane D.A., Thunberg L., Slater A.M., and Lindahl U. Binding of platelet factor 4 to heparin oligosaccharides. Biochem. J. 209 (1983) 455-460
14. Maccarana M., and Lindahl U. Mode of interaction between platelet factor 4 and heparin. Glycobiology 3 (1993) 271-277
15. Krishnaswamy S. Prothrombinase complex assembly. Contributions of protein-protein and protein-membrane interactions toward complex formation. J. Biol. Chem. 265 (1990) 3708-3718
16. Levigne S., Thiec F., Cherel G., et al. Role of the α-helix 163-170 in factor Xa catalytic activity. J. Biol. Chem. 282 (2007) 31569-31579
17. Wilkens M., and Krishnaswamy S. The contribution of factor Xa exosite-dependent substrate recognition by prothrombinase. J. Biol. Chem. 277 (2002) 9366-9374
18. Rezaie A.R. Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex. Blood 97 (2001) 2308-2313
19. Bruffato N., and Nesheim M.E. The use of prothrombin (S525C) labelled with fluorescein to directly study the inhibition of prothrombinase by antithrombin during prothrombin activation. J. Biol. Chem. 276 (2001) 17663-17671