The Use of Prothrombin(S525C) Labeled with Fluorescein to Directly Study the Inhibition of Prothrombinase by Antithrombin during Prothrombin Activation

Journal of Biological Chemistry

Volumn 276, Issue 21, 2001, Pages 17663-17671

  Brufatto, Nicole ^b   Nesheim, Michael E ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; HYDROLYSIS; MUTAGENESIS; RATE CONSTANTS; REACTION KINETICS;

CHROMOGENIC SUBSTRATES;

ENZYMES;

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; CALCIUM ION; CHROMOGENIC SUBSTRATE; CYSTEINE; FLUORESCEIN; HEPARIN; N BENZOYLISOLEUCYL GAMMA GLUTAMYLGLYCYLARGININE 4 NITROANILIDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; PROTHROMBIN; SERINE; UNCLASSIFIED DRUG; FLUORESCENT DYE; THROMBOPLASTIN;

ANIMAL CELL; ARTICLE; BLOOD CLOTTING; CATALYSIS; CELL VACUOLE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME KINETICS; FLUORESCENCE; GENE MUTATION; HALF LIFE TIME; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; REDUCTION; CHEMISTRY; DRUG ANTAGONISM; GENETICS; HUMAN; METABOLISM; MUTATION;

ANIMALIA;

ANTITHROMBINS; BLOOD COAGULATION; FLUORESCENT DYES; HUMANS; MUTATION; PROTHROMBIN; SERINE; THROMBOPLASTIN;

EID: 0035947683     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011586200     Document Type: Article

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