New N4-substituted piperazine naphthamide derivatives as BACE-1 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 24, Issue 1, 2009, Pages 181-187

  Laras, Y ^a   Garino, C ^b   Dessolin, J ^c   Weck, C ^a   Moret, V ^a   Rolland, A ^a   Kraus, J L ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Alzheimer's disease; BACE 1; N4 substituted piperazine naphthamide

Indexed keywords

AMIDE; AMINE; BENZENE DERIVATIVE; BENZYL DERIVATIVE; BETA SECRETASE; BETA SECRETASE INHIBITOR; CARBAMIC ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; NITROGEN DERIVATIVE; PIPERAZINE DERIVATIVE; PIPERAZINE NAPHTHAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ALZHEIMER DISEASE; AMIDES; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CARBOXYLIC ACIDS; HUMANS; PIPERAZINES; PROTEASE INHIBITORS;

EID: 58949089698     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360802048939     Document Type: Article

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