Association of nonsynonymous substitutions in the intermediate region of the vacA gene of helicobacter pylori with gastric diseases in Taiwan

Journal of Clinical Microbiology

Volumn 47, Issue 1, 2009, Pages 249-251

  Sheu, Shew Meei ^a   Hung, Kuei Hsiang ^a   Sheu, Bor Shyang ^b   Yang, Hsiao Bai ^d   Wu, Jiunn Jong ^a,c,e  

^a Institutes of Basic Medical Sciences   (Taiwan)

^b Departments of Medicine   (Taiwan)

^c Medical Laboratory Science and Biotechnology   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

VACUOLATING TOXIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIUM ISOLATE; CONTROLLED STUDY; DUODENUM ULCER; GASTRITIS; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STOMACH CANCER; STOMACH DISEASE; STOMACH ULCER; TAIWAN;

ADULT; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; DNA, BACTERIAL; FEMALE; GENOTYPE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; SEQUENCE ANALYSIS, DNA; TAIWAN;

HELICOBACTER PYLORI;

EID: 58849156973     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.01651-08     Document Type: Article

References (18)

1. Atherton, J. C., P. Cao, R. M. Peek, Jr., M. K. Tummuru, M. J. Blaser, and T. L. Cover. 1995. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 270:17771- 17777.
2. Atherton, J. C., R. M. Peek, Jr., K. T. Tham, T. L Cover, and M. J. Blaser. 1997. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 112:92-99.
3. Basso, D., C. F. Zambon, D. P. Letley, A. Stranges, A. Marchet, J. L. Rhead, S. Schiavon, G. Guariso, M. Ceroti, D. Nitti, M. Rugge, M. Plebani, and J. C. Atherton. 2008. Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms. Gastroenterology 135:91-99.
4. Chen, C. J., S. L. You, L. H. Lin, W. L. Hsu, and Y. W. Yang. 2002. Cancer epidemiology and control in Taiwan: a brief review. Jpn. J. Clin. Oncol. 32(Suppl.):S66-S81.
5. Dunn, B. E., H. Cohen, and M. J. Blaser. 1997. Helicobacter pylori. Clin. Microbiol. Rev. 10:720-741.
6. Ji, X., T. Fernandez, D. Burroni, C. Pagliaccia, J. C. Atherton, J. M. Reyrat, R. Rappuoli, and J. L. Telford. 2000. Cell specificity of Helicobacter pylori cytotoxin is determined by a short region in the polymorphic midregion. Infect. Immun. 68:3754-3757.
7. Letley, D. P., and J. C. Atherton. 2000. Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity. J. Bacteriol. 182:3278-3280.
8. McClain, M. S., P. Cao, H. Iwamoto, A. D. Vinion-Dubiel, G. Szabo, Z. Shao, and T. L. Cover. 2001. A 12-amino-acid segment, present in type s2 but not type s1 Helicobacter pylori VacA proteins, abolishes cytotoxin activity and alters membrane channel formation. J. Bacteriol. 183:6499-6508.
9. Ogiwara, H., D. Y. Graham, and Y. Yamaoka. 2008. vacA i-region subtyping. Gastroenterology 134:1267-1268.
10. Pagliaccia, C., M. de Bernard, P. Lupetti, X. Ji, D. Burroni, T. L. Cover, E. Papini, R. Rappuoli, J. L. Telford, and J. M. Reyrat. 1998. The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity. Proc. Natl. Acad. Sci. USA 95:10212-10217.
11. Pan, Z. J., D. E. Berg, R. W. van der Hulst, W. W. Su, A. Raudonikiene, S. D. Xiao, J. Dankert, G. N. Tytgat, and A. van der Ende. 1998. Prevalence of vacuolating cytotoxin production and distribution of distinct vacA alleles in Helicobacter pylori from China. J. Infect. Dis. 178:220-226.
12. Rhead, J. L., D. P. Letley, M. Mohammadi, N. Hussein, M. A. Mohagheghi, M. Eshagh Hosseini, and J. C. Atherton. 2007. A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer. Gastroenterology 133:926-936.
13. Sheu, B. S., S. M. Sheu, H. B. Yang, A. H. Huang, and J. J. Wu. 2003. Host gastric Lewis expression determines the bacterial density of Helicobacter pylori in babA2 genopositive infection. Gut 52:927-932.
14. Sheu, S. M., B. S. Sheu, H. B. Yang, C. Li, T. C. Chu, and J. J. Wu. 2002. Presence of iceAl but not cagA, cagC, cagE, cagF, cagN, cagT,or orf13 genes of Helicobacter pylori is associated with more severe gastric inflammation in Taiwanese. J. Formos. Med. Assoc. 101:18-23.
15. Strobel, S., S. Bereswill, P. Balig, P. Allgaier, H. G. Sonntag, and M. Kist. 1998. Identification and analysis of a new vacA genotype variant of Helicobacter pylori in different patient groups in Germany. J. Clin. Microbiol. 36:1285-1289.
16. Van Doorn, L. J., C. Figueiredo, F. Megraud, S. Pena, P. Midolo, D. M. Queiroz, F. Carneiro, B. Vanderborght, M. D. Pegado, R. Sanna, W. De Boer, P. M. Schneeberger, P. Correa, E. K. Ng, J. Atherton, M. J. Blaser, and W. G. Quint. 1999. Geographic distribution of vacA allelic types of Helicobacter pylori. Gastroenterology 116:823-830.
17. Wang, H. J., C. H. Kuo, A. A. Yeh, P. C. Chang, and W. C. Wang. 1998. Vacuolating toxin production in clinical isolates of Helicobacter pylori with different vacA genotypes. J. Infect. Dis. 178:207-212.
18. Yamaoka, Y., T. Kodama, O. Gutierrez, J. G. Kim, K. Kashima, and D. Y. Graham. 1999. Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries. J. Clin. Microbiol. 37:2274-2279.