Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity

Journal of Bacteriology

Volumn 182, Issue 11, 2000, Pages 3278-3280

  Letley, D P ^a,b   Atherton, J C ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HELICOBACTER PYLORI; HISTOPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRAIN DIFFERENCE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BACTERIAL TOXINS; CYTOTOXINS; HELICOBACTER PYLORI; MOLECULAR SEQUENCE DATA; PROTEIN SORTING SIGNALS; VARIATION (GENETICS);

EID: 0034043635     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.182.11.3278-3280.2000     Document Type: Article

References (7)

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2. Atherton, J. C., R. M. Peek, Jr., K. T. Tham, T. L. Cover, and M. J. Blaser. 1997. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 112: 92-99.
3. Atherton, J. C., P. M. Sharp, T. L. Cover, G. Gonzalez-Valencia, R. M. Peek, S. A. Thompson, C. J. Hawkey, and M. J. Blaser. 1999. Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, m1 and m2, and have evolved through limited recombination. Curr. Microbiol. 39:211-218.
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6. Suerbaum, S., J. Maynard-Smith, K. Bapumia, G. Morelli, N. H. Smith, E. Kunstmann, I. Dyrek, and M. Achtman. 1998. Free recombination within Helicobacter pylori. Proc. Natl. Acad. Sci. USA 95:12619-12624.
7. Ye, D., D. C. Willhite, and S. R. Blanke. 1999. Identification of the minimal intracellular vacuolating domain of the Helicobacter pylori vacuolating toxin. J. Biol. Chem. 274:9277-9282.