Vitamin-D-receptor genotypes and bone-mineral density in postmenopausal women: Interaction with physical activity

Journal of Aging and Physical Activity

Volumn 17, Issue 1, 2009, Pages 31-45

  Gentil, Paulo ^a   De Lins, Tulio Cesar Lima ^a   Lima, Ricardo Moreno ^a   De Abreu, Breno Silva ^a   Grattapaglia, Dario ^a   Bottaro, Martim ^a   De Oliveira, Ricardo Jacó ^a   Pereira, Rinaldo Wellerson ^a  

^a UNIVERSITY OF BRASILIA   (Brazil)

Author keywords

Brazilians; Genetic association

Indexed keywords

EID: 58849118494     PISSN: 10638652     EISSN: 1543267X     Source Type: Journal    
DOI: 10.1123/japa.17.1.31     Document Type: Article

References (43)

1. Abrams, S.A., Griffin, I.J., Hawthorne, K.M., Chen, Z., Gunn, S.K., Wilde, M., et al. (2005). Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty. Journal of Bone and Mineral Research, 20(6), 945-953.
2. Amling, M., Priemel, M., Holzmann, T., Chapin, K., Rueger, J.M., Baron, R., et al. (1999). Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses. Endocrinology, 140(11), 4982-4987.
3. Arai, H., Miyamoto, K., Taketani, Y., Yamamoto, H., Iemori, Y., Morita, K., et al. (1997). A vitamin D receptor gene polymorphism in the translation initiation codon: Effect on protein activity and relation to bone mineral density in Japanese women. Journal of Bone and Mineral Research, 12(6), 915-921.
4. Bandres, E., Pombo, I., Gonzalez-Huarriz, M., Rebollo, A., Lopez, G., & Garcia-Foncillas, J. (2005). Association between bone mineral density and polymorphisms of the VDR, cERalpha, COL1A1 and CTR genes in Spanish postmenopausal women. Journal of Endocrinological Investigation, 28(4), 312-321.
5. Blanchet, C., Giguere, Y., Prud'homme, D., Dumont, M., Rousseau, F., & Dodin, S. (2002). Association of physical activity and bone: Influence of vitamin D receptor genotype. Medicine and Science in Sports and Exercise, 34(1), 24-31.
6. Clark, A.G. (2004). The role of haplotypes in candidate gene studies. Genetic Epidemiology, 27(4), 321-333.
7. Craig, C.L., Marshall, A.L., Sjostrom, M., Bauman, A.E., Booth, M.L., Ainsworth, B.E., et al. (2003). International physical activity questionnaire: 12-country reliability and validity. Medicine and Science in Sports and Exercise, 35(8), 1381-1395.
8. Cummings, S.R., Kelsey, J.L., Nevitt, M.C., & O'Dowd, K.J. (1985). Epidemiology of osteoporosis and osteoporotic fractures. Epidemiologic Reviews, 7, 178-208.
9. Deng, H.W., Livshits, G., Yakovenko, K., Xu, F.H., Conway, T., Davies, K.M., et al. (2002). Evidence for a major gene for bone mineral density/content in human pedigrees identified via probands with extreme bone mineral density. Annals of Human Genetics, 66(Pt 1), 61-74.
10. Douroudis, K., Tarassi, K., Ioannidis, G., Giannakopoulos, F., Moutsatsou, P., Thalassinos, N., et al. (2003). Association of vitamin D receptor gene polymorphisms with bone mineral density in postmenopausal women of Hellenic origin. Maturitas, 45(3), 191-197.
11. Falchetti, A., Sferrazza, C., Cepollaro, C., Gozzini, A., Del Monte, F., Masi, L., et al. (2007). FokI polymorphism of the vitamin D receptor gene correlates with parameters of bone mass and turnover in a female population of the Italian island of Lampedusa. Calcified Tissue International, 80(1), 15-20.
12. Gentil, P., Lima, R.M., Lins, T.C., Abreu, B.S., Pereira, R.W., & Oliveira, R.J. (2007). Physical activity, Cdx-2 genotype, and BMD. International Journal of Sports Medicine, 28(12), 1065-1069.
13. Jarvinen, T.L., Järvinen, T.A., Sievänen, H., Heinonen, A., Tanner, M., Huang, X.H., et al. (1998). Vitamin D receptor alleles and bone's response to physical activity. Calcified Tissue International, 62(5), 413-417.
14. Johnell, O., & Kanis, J.A. (2004). An estimate of the worldwide prevalence, mortality and disability associated with hip fracture. Osteoporosis International, 15(11), 897-902.
15. Kim, J.G., Kwon, J.H., Kim, S.H., Choi, Y.M., Moon, S.Y., & Lee, J.Y. (2003). Association between vitamin D receptor gene haplotypes and bone mass in postmenopausal Korean women. American Journal of Obstetrics and Gynecology, 189(5), 1234-1240.
16. Kitagawa, I., Kitagawa, Y., Nagaya, T., & Tokudome, S. (2001). Interplay of physical activity and vitamin D receptor gene polymorphism on bone mineral density. Journal of Epidemiology, 11(5), 229-232.
17. Lins, T.C., Nogueira, L.R., Lima, R.M., Gentil, P., Oliveira, R.J., & Pereira, R.W. (2007). A multiplex single-base extension protocol for genotyping Cdx2, FokI, BsmI, ApaI, and TaqI polymorphisms of the vitamin D receptor gene. Genetics and Molecular Research, 6(2), 216-224.
18. Marshall, D., Johnell, O., & Wedel, H. (1996). Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. British Medical Journal, 312(7041), 1254-1259.
19. Matsudo, S., Araújo, T., Matsudo, V., Andrade, D., Andrade, E., Oliveira, L. C., et al. (2001). Questionário internacional de atividade física (IPAQ): Estudo de validade e reprodutibilidade no Brasil. Revista Brasileira de Atividade Física e Saúde, 6(1), 5-18.
20. Moreno Lima, R., Silva de Abreu, B., Gentil, P., Cesar de Lima Lins, T., Grattapaglia, D., Pereira, R.W., et al. (2007). Lack of association between vitamin D receptor genotypes and haplotypes with fat-free mass in postmenopausal Brazilian women. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 62(9), 966-972.
21. Morrison, N.A., Qi, J.C., Tokita, A., Kelly, P.J., Crofts, L., Nguyen, T.V., et al. (1994). Prediction of bone density from vitamin D receptor alleles. Nature, 367(6460), 284-287.
22. Morrison, N.A., Yeoman, R., Kelly, P.J., & Eisman, J.A. (1992). Contribution of transacting factor alleles to normal physiological variability: Vitamin D receptor gene polymorphism and circulating osteocalcin. Proceedings of the National Academy of Sciences of the United States of America, 89(15), 6665-6669.
23. Naganathan, V., MacGregor, A.J., & Sambrook, P.N. (2007). The role of gene-environment interaction in determining bone mineral density in a twin population. Twin Research and Human Genetics, 10(1), 191-197.
24. Nakamura, O., Ishii, T., Ando, Y., Amagai, H., Oto, M., Imafuji, T., et al. (2002). Potential role of vitamin D receptor gene polymorphism in determining bone phenotype in young male athletes. Journal of Applied Physiology, 93(6), 1973-1979.
25. Nguyen, T.V., & Eisman, J.A. (2006). Pharmacogenomics of osteoporosis: Opportunities and challenges. Journal of Musculoskeletal & Neuronal Interactions, 6(1), 62-72.
26. Peacock, M., Turner, C.H., Econs, M.J., & Foroud, T. (2002). Genetics of osteoporosis. Endocrine Reviews, 23(3), 303-326.
27. Puntila, E., Kroger, H., Lakka, T., Tuppurainen, M., Jurvelin, J., & Honkanen, R. (2001). Leisure-time physical activity and rate of bone loss among peri- and postmenopausal women: A longitudinal study. Bone, 29(5), 442-446.
28. Purcell, S., Daly, M.J., & Sham, P.C. (2007). WHAP: Haplotype-based association analysis. Bioinformatics (Oxford, England), 23(2), 255-256.
29. Rabon-Stith, K.M., Hagberg, J.M., Phares, D.A., Kostek, M.C., Delmonico, M.J., Roth, S.M., et al. (2005). Vitamin D receptor FokI genotype influences bone mineral density response to strength training, but not aerobic training. Experimental Physiology, 90(4), 653-661.
30. Rapuri, P. B., Gallagher, J. C., Knezetic, J. A., Kinyamu, H. K., & Ryschon, K. L. (2004). Association between vitamin D receptor polymorphisms and the rate of bone loss in elderly women - Importance of adjusting for dietary and lifestyle factors. Journal of Steroid Biochemistry and Molecular Biology, 89-90(1-5), 503-506.
31. Salamone, L.M., Glynn, N.W., Black, D.M., Ferrell, R.E., Palermo, L., Epstein, R.S., et al. (1996). Determinants of premenopausal bone mineral density: The interplay of genetic and lifestyle factors. Journal of Bone and Mineral Research, 11(10), 1557-1565.
32. Sooy, K., Sabbagh, Y., & Demay, M.B. (2005). Osteoblasts lacking the vitamin D receptor display enhanced osteogenic potential in vitro. Journal of Cellular Biochemistry, 94(1), 81-87.
33. Tajima, O., Ashizawa, N., Ishii, T., Amagai, H., Mashimo, T., Liu, L.J., et al. (2000). Interaction of the effects between vitamin D receptor polymorphism and exercise training on bone metabolism. Journal of Applied Physiology, 88(4), 1271-1276.
34. Thakkinstian, A., D'Este, C., & Attia, J. (2004). Haplotype analysis of VDR gene polymorphisms: A meta-analysis. Osteoporosis International, 15(9), 729-734.
35. Tsuritani, I., Brooke-Wavell, K.S., Mastana, S.S., Jones, P.R., Hardman, A.E., & Yamada, Y. (1998). Does vitamin D receptor polymorphism influence the response of bone to brisk walking in postmenopausal women? Hormone Research, 50(6), 315-319.
36. Uitterlinden, A.G., Fang, Y., Van Meurs, J.B., Pols, H.A., & Van Leeuwen, J.P. (2004). Genetics and biology of vitamin D receptor polymorphisms. Gene, 338(2), 143-156.
37. Uitterlinden, A.G., Pols, H.A., Burger, H., Huang, Q., Van Daele, P.L., Van Duijn, C.M., et al. (1996). A large-scale population-based study of the association of vitamin D receptor gene polymorphisms with bone mineral density. Journal of Bone and Mineral Research, 11(9), 1241-1248.
38. U.S. Department of Health and Human Services. (1996). Physical activity and health: A report from the Surgeon General. Atlanta, GA: National Center for Chronic Disease Prevention and Health Promotion.
39. Vandevyver, C., Wylin, T., Cassiman, J.J., Raus, J., & Geusens, P. (1997). Influence of the vitamin D receptor gene alleles on bone mineral density in postmenopausal and osteoporotic women. Journal of Bone and Mineral Research, 12(2), 241-247.
40. Whitfield, G.K., Remus, L.S., Jurutka, P.W., Zitzer, H., Oza, A.K., Dang, H.T., et al. (2001). Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Molecular and Cellular Endocrinology, 177(1-2), 145-159.
41. Wolfarth, B., Bray, M.S., Hagberg, J.M., Perusse, L., Rauramaa, R., Rivera, M.A., et al. (2005). The human gene map for performance and health-related fitness phenotypes: The 2004 update. Medicine and Science in Sports and Exercise, 37(6), 881-903.
42. Zajickova, K., Zofkova, I., Bahbouh, R., & Krepelova, A. (2002). Vitamin D receptor gene polymorphisms, bone mineral density and bone turnover: FokI genotype is related to postmenopausal bone mass. Physiological Research, 51(5), 501-509.
43. Zmuda, J.M., Cauley, J.A., Danielson, M.E., Wolf, R.L., & Ferrell, R.E. (1997). Vitamin D receptor gene polymorphisms, bone turnover, and rates of bone loss in older African-American women. Journal of Bone and Mineral Research, 12(9), 1446-1452.