Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty

Journal of Bone and Mineral Research

Volumn 20, Issue 6, 2005, Pages 945-953

  Abrams, Steven A ^a,b   Griffin, Ian J ^a   Hawthorne, Keli M ^a   Chen, Zhensheng ^a   Gunn, Sheila K ^a   Wilde, Margaret ^a   Darlington, Gretchen ^a   Shypailo, Roman J ^a   Ellis, Kenneth J ^a  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b CHILDREN S NUTRITION RESEARCH CENTER   (United States)

Author keywords

Bone mineralization; Calcium absorption; Calcium kinetics; Stable isotopes; Vitamin D receptor

Indexed keywords

CALCIUM; PROTEIN FOK1; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE MASS; BONE MINERAL; BONE MINERALIZATION; CALCIUM ABSORPTION; CALCIUM INTAKE; CALCIUM METABOLISM; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC MARKER; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN EXPERIMENT; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NORMAL HUMAN; PUBERTY; SCHOOL CHILD;

ANALYSIS OF VARIANCE; BONE AND BONES; BONE DENSITY; CALCIUM; CHILD; DIET; FEMALE; FRUCTANS; GENOTYPE; HUMANS; IMMUNOASSAY; INULIN; KINETICS; MALE; OSTEOCALCIN; PLACEBOS; POLYMORPHISM, GENETIC; POLYSACCHARIDES; RECEPTORS, CALCITRIOL; SOFTWARE; TIME FACTORS; VITAMIN D;

EID: 19044363722     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.050114     Document Type: Article

References (41)

1. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA 1994 Prediction of bone density form vitamin D receptor alleles. Nature 367:284-287.
2. Ferrari S, Rizzoli R, Chevalley T, Slosman D, Eisman JA, Bonjour J 1995 Vitamin D receptor gene polymorphisms and change in lumbar-spine bone mineral density. Lancet 345:423-424.
3. Cooper GS, Umbach DM 1996 Are vitamin D receptor polymorphisms associated with bone mineral density? A meta-analysis. J Bone Miner Res 11:1841-1849.
4. Garnero P, Borel O, Sornay-Rendu E, Arlot ME, Delmas PD 1996 Vitamin D receptor gene polymorphisms are not related to bone turnover, rate of bone loss, and bone mass in post-menopausal women: The OFELY study. J Bone Miner Res 11:827-834.
5. Willing MC, Torner JC, Burns TL, Janz KF, Marshall T, Gilmore J, Deschenes SP, Warren JJ, Levy SM 2003 Gene polymorphisms, bone mineral density an bone mineral content in young children: The Iowa bone development study. Osteoporos Int 14:650-658.
6. Strandberg S, Nordstrom P, Lorentzon R, Lorentzon M 2003 Vitamin D receptor start codon polymorphism (FokI) is related to bone mineral density in healthy adolescent boys. J Bone Miner Metab 21:109-113.
7. Ames SK, Ellis KJ, Gunn SK, Copeland KC, Abrams SA 1999 Vitamin D receptor gene Fok1 polymorphism predicts calcium absorption and bone mineral density in children. J Bone Miner Res 14:740-746.
8. Dawson-Hughes B, Harris SS, Finneran S 1995 Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype. J Clin Endocrinol Metab 80:3657-3661.
9. Katsumata K, Nishizawa K, Unno A, Fujita Y, Tokita A 2002 Association of gene polymorphisms and bone density in Japanese girls. J Bone Miner Metab 20:164-169.
10. Laaksonen MM, Karkkainen MU, Outila TA, Rita HJ, Lamberg-Allardt CJ 2004 Vitamin D receptor gene start codon polymorphism (FokI) is associated with forearm bone mineral density and calcaneal ultrasound in Finnish adolescent boys but not in girls. J Bone Miner Metab 22:479-485.
11. van der Sluis IM, de Muinck Keizer-Schrama SM, Krenning EP, Pols HA, Uitterlinden AG 2003 Vitamin D receptor gene polymorphism predicts height and bone size, rather than bone density in children and young adults. Calcif Tissue Int 73:332-338.
12. Masi L, Cimaz R, Simonini G, Bindi G, Stagi S, Gozzini A, Malentacchi C, Brandi ML, Falcini F 2002 Association of low bone mass with vitamin D receptor gene and calcitonin receptor gene polymorphisms in juvenile idiopathic arthritis. J Rheumatol 29:2225-2231.
13. Cusack S, Cashman KD 2003 Impact of genetic variation on metabolic response of bone to diet. Proc Nutr Soc 62:901-912.
14. Martin AD, Bailey DA, McKay HA, Whiting S 1997 Bone mineral and calcium accretion during puberty. Am J Clin Nutr 66:611-615.
15. Griffin IJ, Davila PM, Abrams SA 2002 Non-digestible oligosaccharides and calcium absorption in girls with adequate calcium intakes. Br J Nutr 87:5187-5191.
16. Abrams SA, Copeland KC, Gunn SK, Gundberg CM, Klein KO, Ellis KJ 2000 Calcium absorption, bone accretion and kinetics increase during early pubertal development in girls. J Clin Endocrinol Metab 85:1805-1808.
17. Abrams SA, Copeland KC, Gunn SK, Stuff JE, Clarke LL, Ellis KJ 1999 Calcium absorption and kinetics are similar in 7-and 8-year-old Mexican-American and Caucasian girls despite hormonal differences. J Nutr 129:666-671.
18. Abrams SA, Griffin IJ, Hicks PD, Gunn SK 2004 Pubertal girls only partially adapt to low dietary calcium intakes. J Bone Miner Res 19:759-763.
19. Gundberg CM, Niemann SD, Abrams S, Rosen H 1998 Vitamin K status and bone health: An analysis of methods for determination of undercarboxylated osteocalcin. J Clin Endocrinol Metab 83:3258-3266.
20. Abrams SA 1999 Using stable isotopes to assess mineral absorption and utilization by children. Am J Clin Nutr 70:955-964.
21. Chen Z, Griffin IJ, Kriseman YL, Liang LK, Abrams SA 2003 ICP-MS analysis of calcium isotopes from human serum: A low sample volume acid equilibration method. Clin Chem 49:2050-2055.
22. Ellis KJ, Shypailo RJ 1998 Bone mineral and body composition measurements: Cross-calibration of pencil-beam and fan-beam dual-energy X-ray absorptiometers. J Bone Miner Res 13:1613-1618.
23. Ellis KJ, Shypailo RJ, Hardin DS, Perez MD, Motil KJ, Wong WW, Abrams SA 2001 Z-score prediction model for assessment of bone mineral content in pediatric diseases. J Bone Miner Res 16:1658-1664.
24. Lorentzon M, Lorentzon R, Backstron T, Nordstrom P 1999 Estrogen receptor gene polymorphism, but not estradiol levels, is related to bone density in healthy adolescent boys: A cross-sectional and longitudinal study. J Clin Endocrinol Metab 84:4597-4601.
25. Fleet JC, Harris SS, Wood RJ, Dawson-Hughes B 1995 The Bsm1 vitamin D receptor restriction fragment length polymorphism (BB) predicts low bone density in premenopausal black and white women. J Bone Miner Res 10:985-990.
26. Nakamura M, Morimoto S, Zhang Z, Utsunomiya H, Inagami T, Ogihara T, Kakudo K 2001 Calcitonin receptor gene polymorphism in Japanese women: Correlation with body mass and bone mineral density. Calcif Tissue Int 68:211-215.
27. Neer R, Berman M, Fisher F, Rosenberg LE 1967 Multicompartmental analysis of calcium kinetics in normal adult males. J Clin Invest 46:1364-1378.
28. Ellis KJ, Shypailo RJ, Hergenroeder A, Perez M, Abrams S 1996 Total body calcium and bone mineral content: Comparison of dual-energy X-ray absorptiometry (DXA) with neutron activation analysis (NAA). J Bone Miner Res 11:843-848.
29. Ferrari S, Rizzoli R, Manen D, Slosman D, Bonjour JP 1998 Vitamin D receptor gene start codon polymorphisms (Fok1) and bone mineral density: Interaction with age, dietary calcium, and 3′-end region polymorphisms. J Bone Miner Res 13:925-930.
30. Ferrari S, Rizzoli R, Slosman D, Bonjour JP 1998 Do dietary calcium and age explain the controversy surrounding the relationship between bone mineral density and vitamin D receptor gene polymorphisms? J Bone Miner Res 13:363-370.
31. Kelly PJ, Eisman JA, Sambrook PN 1990 Interaction of genetic and environmental influences on peak bone density. Osteoporos Int 1:56-60.
32. Kelly PJ, Morrison NA, Sambrook PN, Nguyen TV, Eisman JA 1995 Genetic influences on bone turnover, bone density and fracture. Eur J Endocrinol 133:265-271.
33. Cooper GS, Umbach DM 1996 Are vitamin D receptor polymorphisms associated with bone mineral density? A meta-analysis. J Bone Miner Res 11:1841-1849.
34. Zajickova K, Zofkova I, Bahbouh R, Krepelova A 2002 Vitamin D receptor gene polymorphisms, bone mineral density and bone turnover: FokI genotype is related to postmenopausal bone mass. Physiol Res 51:501-509.
35. Eccleshall TR, Garnero P, Gross C, Delmas PD, Feldman D 1998 Lack of correlation between start codon polymorphism of the vitamin D receptor gene and bone mineral density in premenopausal French women: The OFELY study. J Bone Miner Res 13:31-35.
36. Zmuda JM, Cauley JA, Danielson ME, Wolf RL, Ferrel RE 1997 Vitamin D-receptor gene polymorphisms, bone turnover, and rates of bone loss in older African-American women. J Bone Miner Res 12:1446-1452.
37. Gunnes M, Berg JP, Halse J, Lehmann EJ 1997 Lack of relationship between vitamin D receptor genotype and forearm bone gain in healthy children, adolescents, and young adults. J Clin Endocrinol Metab 82:851-855.
38. Rapuri PB, Gallagher JC, Knezetic JA, Kinyamu HK, Ryschon KL 2004 Association between Vitamin D receptor polymorphisms and the rate of bone loss in elderly women-importance of adjusting for dietary and lifestyle factors. J Steroid Biochem Mol Biol 89-90:503-506.
39. Nakamura O, Ishii T, Ando Y, Amagai H, Oto M, Imafuji T, Tokuyama K 2002 Potential role of vitamin D receptor gene polymorphism in determining bone phenotype in young male athletes. J Appl Physiol 93:1973-1979.
40. Gross C, Krishnama AV, Malloy PJ, Eccleshall TR, Zhao XY, Feldman D 1998 The vitamin D receptor gene start codon polymorphism: A functional analysis of Fok1 variants. J Bone Miner Res 13:1691-1699.
41. Ma J, Stampfer MJ, Gann PH, Hough HL, Giovannucci E, Kelsey KT, Hennekens CH, Hunter DJ 1998 Vitamin D receptor polymorphisms, circulating vitamin D metabolites, and risk of prostate cancer in United States physicians. Cancer Epidemiol Biomarkers Prev 7:385-390.