Potential role of vitamin D receptor gene polymorphism in determining bone phenotype in young male athletes

Journal of Applied Physiology

Volumn 93, Issue 6, 2002, Pages 1973-1979

  Nakamura, Orie ^a   Ishii, Tomoo ^b   Ando, You ^b   Amagai, Hitoshi ^c   Oto, Masakazu ^b   Imafuji, Takahiro ^b   Tokuyama, Kumpei ^b  

^a CHUBU NATIONAL HOSPITAL   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c Tsukuba Coll Med Technol/Nursing   (Japan)

Author keywords

Bone mineral content; Bone mineral density; Bone volume; Gene environment interaction; Translation initiation site

Indexed keywords

ENDONUCLEASE; ENDONUCLEASE FOK I; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR;

ADAPTATION; ADULT; ARTICLE; ATHLETE; BONE; BONE MINERAL; CONTROLLED STUDY; DNA POLYMORPHISM; FEMUR NECK; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HUMAN EXPERIMENT; LUMBAR SPINE; MALE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSLATION INITIATION; BONE DENSITY; CROSS-SECTIONAL STUDY; GENETICS; PHYSIOLOGY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SPORT; WEIGHT BEARING;

ADULT; BONE AND BONES; BONE DENSITY; CROSS-SECTIONAL STUDIES; GENOTYPE; HUMANS; MALE; PHENOTYPE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, CALCITRIOL; SPORTS; WEIGHT-BEARING;

EID: 0036892583     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00663.2002     Document Type: Article

References (52)

1. Ames SK, Ellis KJ, Gunn SK, Copeland KC, and Abrams SA. Vitamin D receptor gene Fok I polymorphism predicts calcium absorption and bone mineral density in children. J Bone Miner Res 14: 740-746, 1999.
2. Arai H, Miyamoto K, Taketani Y, Yamamoto H, Iemori Y, Morita K, Tonai T, Nishisho T, Mori S, and Takeda E. A vitamin D receptor gene polymorphism in the translation initiation codon: Effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res 12: 915-921, 1997.
3. Ashizawa N, Nonaka K, Michikami S, Mizuki T, Amagai H, Tokuyama K, and Suzuki M. Tomographical description of tennis-loaded radius: Reciprocal relation between bone size and volumetric BMD. J Appl Physiol 86: 1347-1351, 1999.
4. Blanchet C, Giguere Y, Prud'homme D, Dumont M, Rousseau F, and Dodin S. Association of physical activity and bone: Influence of vitamin D receptor genotype. Med Sci Sports Exerc 34: 24-31, 2002.
5. Bradney M, Karlsson MK, Duan Y, Stuckey S, Bass S, and Seeman E. Heterogeneity in the growth of the axial and appendicular skeleton in boys: Implications for the pathogenesis of bone fragility in men. J Bone Miner Res 15: 1871-1878, 2000.
6. Brahm H, Mallmin H, Michaëlsson K, Ström H, and Ljunghall S. Relationships between bone mass measurements and lifetime physical activity in a Swedish population. Calcif Tissue Int 62: 400-412, 1998.
7. Bray MS. Genomics, genes, and environmental interaction: The role of exercise. J Appl Physiol 88: 787-792, 2000.
8. Carter DR, Bouxsein ML, and Marcus R. New approaches for interpreting projected bone densitometry data. J Bone Miner Res 7: 137-145, 1992.
9. Chilibeck PD, Sale DG, and Webber CE. Exercise and bone mineral density. Sports Med 19: 103-122, 1995.
10. 3. Clin Endocrinol (Oxf) 52: 211-216, 2000.
11. Creighton DL, Morgan AL, Boardley D, and Brolinson PG. Weight-bearing exercise and markers of bone turnover in female athletes. J Appl Physiol 90: 565-570, 2001.
12. Eccleshall TR, Garnero P, Gross C, Delmas PD, and Feldman D. Lack of correlation between start codon polymorphism of the vitamin D receptor gene and bone mineral density in premenopausal French women: The OFELY study. J Bone Miner Res 13: 31-35, 1998.
13. Frost HM. Vital biomechanics: Proposed general concepts for skeletal adaptations to mechanical usage. Calcif Tissue Int 42: 145-156, 1988.
14. Fujita Y, Katsumata K, Unno A, Tawa T, and Tokita A. Factors affecting peak bone density in Japanese women. Calcif Tissue Int 64: 107-111, 1999.
15. Gong G, Stern HS, Cheng SC, Fong N, Mordeson J, Deng HW, and Recker RR. The association of bone mineral density with vitamin D receptor gene polymorphisms. Osteoporos Int 9: 55-64, 1999.
16. Gross C, Eccleshall TR, Malloy PJ, Villa ML, Marcus R, and Feldman D. The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. J Bone Miner Res 11: 1850-1855, 1996.
17. Gross C, Krishnan AV, Malloy PJ, Eccleshall TR, Zhao XY, and Feldman D. The vitamin D receptor gene start codon polymorphism: A functional analysis of Fok I variants. J Bone Miner Res 13: 1691-1699, 1998.
18. Haapasalo H, Kontulainen S, Sievanen H, Kannus P, Jarvinen M, and Vuori I. Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: A peripheral quantitative computed tomography study of the upper arms of male tennis players. Bone 27: 351-357, 2000.
19. Hannah SS and Norman AW. 1 α,25(OH)2 vitamin D3-regulated expression of the eukaryotic genome. Nutr Rev 52: 376-382, 1994.
20. Harris SS, Eccleshall TR, Gross C, Dawson-Hughes B, and Feldman D. The vitamin D receptor start codon polymorphism (Fok I) and bone mineral density in premenopausal American black and white women. J Bone Miner Res 12: 1043-1048, 1997.
21. Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH, Encians Dominguez C, and Jurutka PW. The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed. J Bone Miner Res 13: 325-349, 1998.
22. Heinonen A, Sievänen H, Kyröläinen H, Perttunen J, and Kannus P. Mineral mass, size, and estimated mechanical strength of triple jumpers' lower limb. Bone 29: 279-285, 2001.
23. Jurutka PW, Remus LS, Whitfield GK, Thompson PD, Hsieh JC, Zitzer H, Tavakkoli P, Galligan MA, Dang HTL, Haussler CA, and Haussler MR. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinol 14: 401-420, 2000.
24. Järvinen TLN, Järvinen TAH, Sievänen H, Heinonen A, Tanner M, Huang XH, Nenonen A, Isola JJ, Järvinen M, and Kannus P. Vitamin D receptor alleles and bone's response to physical activity. Calcif Tissue Int 62: 413-417, 1998.
25. Kanan RM, Varanasi SS, Francis RM, Parker L, and Datta HK. Vitamin D receptor gene start codon polymorphism (Fok I) and bone mineral density in healthy male subjects. Clin Endocrinol (Oxf) 53: 93-98, 2000.
26. Katsumata K, Nishizawa K, Unno A, Fujita Y, and Tokita A. Association of gene polymorphisms and bone density in Japanese girls. J Bone Miner Metab 20: 164-169, 2002.
27. Lu PW, Cowell CT, Lloyd-Jones SA, Briody JN, and Howman-Giles R. Volumetric bone mineral density in normal subjects, aged 5-27 years. J Clin Endocrinol Metab 81: 1586-1590, 1996.
28. Morel J, Combe B, Francisco J, and Bernard J. Bone mineral density of 704 amateur sportsmen involved in different physical activities. Osteoporos Int 12: 152-157, 2001.
29. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, and Eisman JA. Prediction of bone density from vitamin D receptor alleles. Nature 367: 284-287, 1994.
30. Nakamura O, Ishii T, Mankyu H, Tsubakimoto S, Nomura T, and Tokuyama K. Contribution of vitamin D receptor genotypes to bone mineral density in young male athletes with different impact loading. Eur J Sport Sci 2: 1-8, 2002.
31. Nelson DA and Koo WWK. Interpretation of absorptiometric bone mass measurements in the growing skeleton: Issues and limitations. Calcif Tissue Int 65: 1-3, 1999.
32. Pettersson U, Nordström P, Alfredson H, Henriksson-Larsén K, and Lorentzon R. Effect of high impact activity on bone mass and size in adolescent females: A comparative study between two different types of sports. Calcif Tissue Int 67: 207-214, 2000.
33. Platen P, Chae EH, Antz R, Lehmann R, Kühlmorgen J, and Allolio B. Bone mineral density in top level male athletes of different sports. Eur J Sport Sci 1: 1-15, 2001.
34. Rankinen T, Pérusse L, Rauramaa R, Pivera MA, Wolfarth B, and Bouchard C. The human gene map for performance and health-related fitness phenotypes. Med Sci Sports Exerc 33: 855-867, 2001.
35. Rubin LA, Hawker GA, Peltekova VD, Fielding LJ, Ridout R, and Cole DEC. Determinants of peak bone mass: Clinical and genetic analyses in a young female Canadian cohort. J Bone Miner Res 14: 633-643, 1999.
36. Ruff CB and Hayes NC. Subperiostal expansion and cortical remodeling of human femur and tibia with aging. Science 217: 945-948, 1982.
37. Saijo T, Ito M, Takeda E, Huq AHMM, Naito E, Yokota I, Sone T, Pike W, and Kuroda Y. A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: Utility of single-strand conformation polymorphism analysis for heterozygous carrier detection. Am J Hum Genet 49: 668-673, 1991.
38. Salamone LM, Glynn NW, Black DM, Ferrell RE, Palermo L, Epstein RS, Kuller LH, and Cauley JA. Determinants of premenopausal bone mineral density: The interplay of genetic and lifestyle factors. J Bone Miner Res 11: 1557-1565, 1996.
39. Schönaü E, Wentzlik U, Michalk D, Scheidhauer K, and Klein K. Is there an increase of bone density in children? Lancet 342: 689-690, 1993.
40. Seeman E, Duan Y, Fong C, and Edmonds J. Fracture site-specific deficits in bone size and volumetric density in men with spine or hip fractures. J Bone Miner Res 16:120-127, 2001.
41. Seeman E. The structural basis of bone fragility in men. Bone 25: 143-147, 1999.
42. Seeman E. From density to structure: Growing up and growing old on the surfaces of bone. J Bone Miner Res 12: 509-521, 1997.
43. Seeman E. Sexual dimorphism in skeletal size, density and strength. J Clin Endocrinol Metab 86: 4576-4584, 2001.
44. Sievänen H, Kannus P, and Vuori I. Dual energy X-ray absorptiometry is also an accurate and precise method to measure the dimensions of human long bones. Calcif Tissue Int 54: 101-105, 1994.
45. Suominen H. Bone mineral density and long term exercise: An overview of cross-sectional athlete studies. Sports Med 16: 316-330, 1993.
46. Tabensky AD, Williams J, Deluca V, Briganti E, and Seeman E. Bone mass, areal, and volumetric bone density are equally accurate, sensitive, and specific surrogates of the breaking strength of the vertebral body: An in vitro study. J Bone Miner Res 11: 1981-1988, 1996.
47. Tajima O, Ashizawa N, Ishii T, Amagai H, Mashimo T, Liu LJ, Saitoh Tokuyama KS, and Suzuki M. Interaction of the effects between vitamin D receptor polymorphism and exercise training on bone metabolism. J Appl Physiol 88: 1271-1276, 2000.
48. Tsuritani I, Brooke-Wavell KSF, Mastana SS, Jones PRM, Hardman AE, and Yamada Y. Does vitamin D receptor polymorphism influence the response of bone to brisk walking in postmenopausal women? Horm Res 50: 315-319, 1998.
49. Turner CH and Pavalko FM. Mechanotransduction and functional response of the skeleton to physical stress: The mechanisms and mechanics of bone adaptation. J Orthop Sci 3: 346-355, 1998.
50. Whitfield GK, Remus LS, Jurutka PW, Zitzer H, Oza AK, Dang HT, Haussler CA, Galligan MA, Thatcher ML, Encinas Dominguez C, and Haussler MR. Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol Cell Endocrinol 177: 145-159, 2001.
51. Wittich A, Mautalen CA, Oliveri MB, Bagur A, Somoza F, and Rotemberg E. Professional football (soccer) players have a markedly greater skeletal mineral content, density and size than age- and BMI-matched controls. Calcif Tissue Int 63: 112-117, 1998.
52. Zmuda JM, Cauley JA, Danielson ME, Theobald TM, and Ferrell RE. Vitamin D receptor translation initiation codon polymorphism and markers of osteoporotic risk in older African-American women. Osteoporos Int 9: 214-219, 1999.