Physical activity, Cdx-2 genotype, and BMD

International Journal of Sports Medicine

Volumn 28, Issue 12, 2007, Pages 1065-1069

  Gentil, Paulo ^a   Lima, R M ^a   Lins, T C L ^a   Abreu, B S ^a   Pereira, R W ^a   Oliveira, R J ^a  

^a UNIVERSIDADE CATÓLICA DE BRASÍLIA   (Brazil)

Author keywords

Genetics; Minisequencing; Osteoporosis; Vitamin D receptor

Indexed keywords

TRANSCRIPTION FACTOR CDX2;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; BONE DENSITOMETRY; BONE DENSITY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GENE SEQUENCE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; PHYSICAL ACTIVITY; POSTMENOPAUSE;

ABSORPTIOMETRY, PHOTON; AGED; ANALYSIS OF VARIANCE; BONE DENSITY; BRAZIL; CROSS-SECTIONAL STUDIES; FEMALE; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; MIDDLE AGED; MOTOR ACTIVITY; POLYMORPHISM, GENETIC; POSTMENOPAUSE; QUESTIONNAIRES; TRANS-ACTIVATORS;

EID: 37249080119     PISSN: 01724622     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-965130     Document Type: Article

References (34)

1. Abrams SA, Griffin IJ, Hawthorne KM, Chen Z, Gunn SK, Wilde M, Darlington G, Shypailo RJ, Ellis KJ. Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics and bone mineralization rates during puberty. J Bone Miner Res 2005; 20: 945-953
2. Ames SK, Ellis KJ, Gunn SK, Copeland KC, Abrams SA. Vitamin D receptor gene Fok1 polymorphism predicts calcium absorption and bone mineral density in children. J Bone Miner Res 1999; 14: 740-746
3. Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, Baron R, Demay MB. Rescue of the skeletal phenotype of vitamin D receptor ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 1999; 140: 4982-4987
4. Arai H, Miyamoto K, Yoshida M, Yamamoto H, Taketani Y, Morita K, Kubota M, Yoshida S, Ikeda M, Watabe F, Kanemasa Y, Takeda E. The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene. J Bone Miner Res 2001; 16: 1256-1264
5. Block JE. Interpreting studies of exercise and osteoporosis: a call for rigor. Control Clin Trials 1997; 18: 54-57
6. Bray MS. Genomics, genes, and environmental interaction: the role of exercise. J Appl Physiol 2000; 88: 787-792
7. Coupland CA, Cliffe SJ, Bassey EJ, Grainge MJ, Hosking DJ, Chilvers CE. Habitual physical activity and bone minetal density in postmenopausal women in England. Int J Epidemiol 1999; 28: 241-246
8. Cummings SR. Risk factors for hip fractures in white women. N Engl J Med 1995; 332: 767-773
9. Deng HW, Livshits G, Yakovenko K, Xu FH, Conway T, Davies KM, Deng H, Recker RR. Evidence for a major gene for bone mineral density/content in human pedigrees identified via probands with extreme bone mineral density. Ann Hum Genet 2002; 66: 61-74
10. Dequecker J, Nijs J, Verstraeten A, Geusens P, Gevers G. Genetic determinants of bone mineral content at the spine and tadius: a twin study. Bone 1987; 8: 207-209
11. Fang Y, Van Meurs JBJ, Bergink A, Hofman A, Van Dujin CM, Van Leeuwen JPTM, Pols HAP, Utterlinden AG. Cdx-2 polymorphism in the promoter region of the human vitamin D receptor gene determines susceptibility to fracture in the elderly. J Bone Miner Res 2003; 18: 1632-1641
12. Feskanich D, Willett W, Colditz G. Walking and leisure-time activity and risk of hip fracture in postmenopausal women. JAMA 2002; 288: 2300-2306
13. Geusens P, Vandevyver C, Vanhoof J, Cassiman JJ, Boonen S, Raus J. Quadriceps and grip strength are related to vitamin D receptor genotype in elderly nonobese women. J Bone Miner Res 1997; 12: 2082-2088
14. Hallal PC, Victora CG, Wells JC, Lima RC. Physical inactivity: prevalence and associated variables in Brazilian adults. Med Sci Sports Exerc 2003; 35: 1894-1900
15. Johnell O, Kanis JA. An estimate of the worldwide prevalence, mortality and disability associated with hip fracture. Osteoporos Int 2004; 15: 897-902
16. Kelley GA. Exercise and regional bone mineral density in postmenopausal women: a meta-analytic review of randomized trials. Am J Phys Med Rehabil 1998; 77: 76-87
17. Li YC, Amling M, Pino AE, Priemel M, Meuse J, Baron R, Delling G, Demay MB. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 1998; 139: 4391-4396
18. Lins TCL, Nogueira LR, Lima RM, Gentil P, Oliveira RJ, Pereira RW. A multiplex single-base extension protocol for genotyping Cdx2, Fok1, Bsm1, Apa1, and Taq1 polymorphisms of the vitamin D receptor gene. Genet Mol Res 2007; 6: 216-224
19. Liu YZ, Liu YJ, Recker RR, Deng HW. Molecular studies of identification of genes for osteoporosis: the 2002 update. J Endocrinol 2003; 177: 147-196
20. Livshits G, Karasik D, Pavlovsky O, Kobyliansky E. Segregation analysis reveals a major gene effect in compact and cancellous bone mineral density in 2 populations. Hum Biol 1999; 71: 155-172
21. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 1996; 312: 1254-1259
22. Matsudo S, Araújo T, Matsudo V, Andrade D, Andrade E, Oliveira LC, Braggion G. Questionário Internacional de atividade física (IPAQ): estudo de validade e reprodutibilidade no Brasil. Rev Bras Ativ Fís Saúde 2001; 6: 5-18
23. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1998; 16: 1215
24. Morita A, Iki M, Dohi Y, Ikeda Y, Kagamimori S, Kagawa Y, Yoneshima H. Effects of the Cdx-2 polymorphism of the vitamin D receptor gene and lifestyle factors on bone minetal density in a representative sample of Japanese women: the Japanese Population-based Osteoporosis (JPOS) Study. Calcif Tissue Int 2005; 77: 339-347
25. NIH - National Institute of Health. Osteoporosis, prevention, diagnosis and therapy. NIH Consens Statement 2000; 17: 1-45
26. Pate RR, Pratt M, Blair SN, Haskell WL, MACERA CA, Bouchard C, Buchner D, Ettinger W, Heath GW, King AC, Kriska A, Leon AS, Marcus BH, Morris J, Paffenberger RS, Patrick K, Pollock ML, Rippe JM, Sallis J, Wilmore JH. Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 1995; 273: 402-407
27. Puntila E, Kroger H, Lakka T, Tuppurainen M, Jurvelin J, Honkanen R. Leisure-time physical activity and rate of bone loss among peri- and postmenopausal women: a longitudinal study. Bone 2001; 29: 442-446
28. Ralston SH. Genetic control of susceptibility to osteoporosis. J Clin Endocrinol Metab 2002; 87: 2460-2466
29. Slemenda CW, Christian JC, Williams CJ, Norton JA, Johnston CC Jr. Genetic determinants of bone mass in adult women: a reevaluation of the twin model and the potential importance of gene interaction on heritability estimates. J Bone Miner Res 1991; 6: 561-567
30. Sooy K, Sabbagh Y, Demay MB. Osteoblasts lacking the vitamin D receptor display enhanced osteogenic potential in vitro. J Cell Biochem 2005; 94: 81-87
31. Tsai HJ, Choudhry S, Naqvi M, Rodriguez-Cintron W, Burchard EG, Ziv E. Comparison of three methods to estimate genetic ancestry and control for stratification in genetic association studies among admixed populations. Hum Genet 2005; 118: 424-433
32. USDHHS - U.S. Department Of Health And Human Services. Physical Activity and Health: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, 1996
33. Wolfarth B, Bray MS, Hagberg JM, Perusse L, Rauramaa R, Rivera MA, Roth SM, Rankinen T, Bouchard C. The human gene map for performance and health-related fitness phenotypes: the 2004 update. Med Sci Sports Exerc 2005; 37: 881-903
34. Yamamoto H, Miamoto Kl, Li B, Taketani Y, Kitano M, Inoue Y, Morita K, Pike JW, Takeda E. The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine. J Bone Miner Res 1999; 14: 240-247