A G-protein γ subunit mimic is a general antagonist of prion propagation in Saccharomyces cerevisiae

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 3, 2009, Pages 791-796

  Ishiwata, Masao ^a   Kurahashi, Hiroshi ^a   Nakamura, Yoshikazu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

PIN+ ; PSI+ ; URE3 ; Gpg1; Yeast prion

Indexed keywords

AMYLOID PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; HEAT SHOCK PROTEIN 104; POLYGLUTAMINE; PRION PROTEIN; TRANSLATION TERMINATION FACTOR; TRANSLATION TERMINATION FACTOR SUP35; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE MUTATION; GENE OVEREXPRESSION; HYDROPHOBICITY; INHIBITION KINETICS; MODULATION; MOLECULAR MIMICRY; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HEAT-SHOCK PROTEINS; MUTATION; PRIONS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 58849102280     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808383106     Document Type: Article

References (35)

1. Prusiner SB (2004) Early evidence that a protease-resistant protein is an active component of the infectious prion. Cell 116:S109.
2. Prusiner SB (1982) Novel proteinaceous infectious particles cause scrapie. Science 216:136-144.
3. Wickner RB (1994) [URE3] as an altered URE2 protein: Evidence for a prion analog in Saccharomyces cerevisiae. Science 264:566-569.
4. Sondheimer N, Lindquist S (2000) Rnq1: An epigenetic modifier of protein function in yeast. Mol Cell 5:163-172.
5. Du Z, Park KW, Yu H, Fan Q, Li L (2008) Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae. Nat Genet 40:460-465.
6. Cox BS (1965) ψ, a cytoplasmic suppressor of super-suppressor in yeast. Heredity 20:505-521.
7. +] in the yeast Saccharomyces cerevisiae. Genetics 137:671-676.
8. Zhouravleva G, et al. (1995) Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3. EMBO J 14:4065-4072.
9. +] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor. EMBO J 15:3127-3134.
10. Stansfield I, et al. (1995) The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae. EMBO J 14:4365-4373.
11. +], and Ribosome Recycling (Cold Spring Harbor Laboratory Press, New York) pp 173-196.
12. + determinant suppresses nonsense mutations in yeast. J Bacteriol 139:1068-1071.
13. Patino MM, Liu JJ, Glover JR, Lindquist S (1996) Support for the prion hypothesis for inheritance of a phenotypic trait in yeast. Science 273:622-626.
14. Kurahashi H, Nakamura Y (2007) Channel mutations in Hsp104 hexamer distinctively affect thermotolerance and prion-specific propagation. Mol Microbiol 63:1669-1683.
15. Kurahashi H, Ishiwata M, Shibata S, Nakamura Y (2008) A regulatory role of the Rnq1 nonprion domain for prion propagation and polyglutamine aggregates. Mol Cell Biol 28:3313-3323.
16. Harashima T, Heitman J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell 10:163-173.
17. Sprang SR (1997) G protein mechanisms: Insights from structural analysis. Annu Rev Biochem 66:639-678.
18. Hoffman CS (2005) Except in every detail: Comparing and contrasting G-protein signaling in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Eukaryot Cell 4:495.
19. +]. Cell 106:171-182.
20. +] prion. Cell 106:183-194.
21. +] prions in yeast. Methods 39:23-34.
22. Magasanik B, Kaiser CA (2002) Nitrogen regulation in Saccharomyces cerevisiae. Gene 290:1-18.
23. Brachmann A, Baxa U, Wickner RB (2005) Prion generation in vitro: Amyloid of Ure2p is infectious. EMBO J 24:3082-3092.
24. Meriin AB, et al. (2002) Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1. J Cell Biol 157:997-1004.
25. Gokhale KC, Newnam GP, Sherman MY, Chernoff YO (2005) Modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model. J Biol Chem 280:22809-22818.
26. Ogura T, Wilkinson AJ (2001) AAA+ superfamily ATPases: Common structure-diverse function. Genes Cells 6:575-597.
27. Jung G, Jones G, Masison DC (2002) Amino acid residue 184 of yeast Hsp104 chaperone is critical for prion-curing by guanidine, prion propagation, and thermotolerance. Proc Natl Acad Sci USA 99:9936-9941.
28. Ness F, Ferreira P, Cox BS, Tuite MF (2002) Guanidine hydrochloride inhibits the generation of prion "seeds" but not prion protein aggregation in yeast. Mol Cell Biol 22:5593-5605.
29. Sanchez Y, Lindquist SL (1990) HSP104 required for induced thermotolerance. Science 248:1112-1115.
30. Parsell DA, Kowal AS, Singer MA, Lindquist S (1994) Protein disaggregation mediated by heat-shock protein Hsp104. Nature 372:475-478.
31. +]. Science 268:880-884.
32. +] prion in Saccharomyces cerevisiae. Genetics 147:507-519.
33. Moriyama H, Edskes HK, Wickner RB (2000) [URE3] prion propagation in Saccharomyces cerevisiae: Requirement for chaperone Hsp104 and curing by overexpressed chaperone Ydj1p. Mol Cell Biol 20:8916-8922.
34. Jones DT (1999) Protein secondary structure prediction based on position-specific scoring matrices. J Mol Biol 292:195-202.
35. Derkatch IL, Liebman SW (2007) Prion-prion interactions. Prion 1:161-169.