HTLV-1 Tax protein cooperates with Ras in protecting cells from apoptosis

Apoptosis

Volumn 14, Issue 2, 2009, Pages 153-163

  Vajente, Nicola ^a   Trevisan, Roberta ^a   Saggioro, Daniela ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

Author keywords

Apoptosis; Erk1 2; GAP1m; HTLV 1; Ras; Tax

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; ONCOPROTEIN; RAS PROTEIN; TAX PROTEIN;

APOPTOSIS; ARTICLE; CELL PROTECTION; HELA CELL; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; MALIGNANT TRANSFORMATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYTOPROTECTION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE PRODUCTS, TAX; HELA CELLS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; IMMUNOPRECIPITATION; MAP KINASE SIGNALING SYSTEM; MUTANT PROTEINS; PHOSPHORYLATION; POLYISOPRENYL PHOSPHATES; PRENYLATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS P21(RAS); RAS GTPASE-ACTIVATING PROTEINS; RESPONSE ELEMENTS; TRANSCRIPTION, GENETIC; TRANSFECTION;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 58849095725     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-008-0289-3     Document Type: Article

References (57)

1. BJ Poiesz FW Ruscetti MS Reitz 1981 Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with sezary T-cell leukaemia Nature 294 268 271 10.1038/294268a0
2. Y Hinuma K Nagata M Hanaoka 1981 Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera Proc Natl Acad Sci USA 78 6476 6480 10.1073/pnas.78.10.6476
3. A Gessain F Barin JC Vernant 1985 Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis Lancet 2 407 410 10.1016/S0140-6736(85)92734-5
4. R Grassmann M Aboud KT Jeang 2005 Molecular mechanisms of cellular transformation by HTLV-1 Tax Oncogene 24 5976 5985 10.1038/sj.onc.1208978
5. H Hasegawa H Sawa MJ Lewis 2006 Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I Nat Med 12 466 472 10.1038/nm1389
6. R Grassmann C Dengler I Muller-Fleckenstein 1989 Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector Proc Natl Acad Sci USA 86 3351 3355 10.1073/pnas.86.9.3351
7. MD Robek L Ratner 1999 Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone J Virol 73 4856 4865
8. M Yoshida 2001 Multiple viral strategies of HTLV-1 for dysregulation of cell growth control Annu Rev Immunol 19 475 496 10.1146/annurev.immunol.19.1.475
9. G Franchini C Nicot JM Johnson 2003 Seizing of T cells by human T-cell leukemia/lymphoma virus type 1 Adv Cancer Res 89 69 132 10.1016/S0065-230X(03) 01003-0
10. OJ Semmes JF Barret CV Dang KT Jeang 1996 Human T-cell leukemia virus type I tax masks c-Myc function through a cAMP-dependent pathway J Biol Chem 271 9730 9738 10.1074/jbc.271.16.9730
11. C Neuveut KG Low F Maldarelli 1998 Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb Mol Cell Biol 18 3620 3632
12. T Suzuki T Narita M Uchida-Toita M Yoshida 1999 Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms Virology 259 384 391 10.1006/viro.1999.9760
13. K Haller Y Wu E Derow I Schmitt KT Jeang 2002 Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein Mol Cell Biol 22 3327 3338 10.1128/MCB.22.10.3327-3338.2002
14. T Suzuki S Kitao H Matsushime M Yoshida 1996 HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4 EMBO J 15 1607 1614
15. C Neuveut KT Jeang 2000 HTLV-I Tax and cell cycle progression Prog Cell Cycle Res 4 157 162
16. K Wu ME Bottazzi C de la Fuente 2004 Protein profile of tax-associated complexes J Biol Chem 279 495 508 10.1074/jbc.M310069200
17. L Chieco-Bianchi D Saggioro A Del Mistro 1988 Chromosome damage induced in cord blood T-lymphocytes infected in vitro by HTLV-I Leukemia 2 223S 232S
18. D Saggioro F Majone M Forino 1994 Tax protein of human T-lymphotropic virus type I triggers DNA damage Leuk Lymphoma 12 281 286 10.3109/ 10428199409059600
19. FJ Lemoine SJ Marriott 2002 Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein. Tax Oncogene 21 7230 7234 10.1038/sj.onc.1205898
20. JM Mesnard C Devaux 1999 Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein Virology 257 277 284 10.1006/viro.1999.9685
21. C De la Fuente L Wang D Wang 2003 Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells Mol Cell Biochem 245 99 113 10.1023/A:1022866027585
22. CA Pise-Masison M Radonovich R Mahieux 2002 Transcription profile of cells infected with human T-cell leukemia virus type I compared with activated lymphocytes Cancer Res 62 3562 3571
23. K Tsukasaki S Tanosaki S De Vos 2004 Identifying progression-associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide microarrays Int J Cancer 109 875 881 10.1002/ijc.20028
24. R Trevisan L Daprai L Acquasaliente 2004 Relevance of CREB phosphorylation in the anti-apoptotic function of human T-lymphotropic virus type 1 tax protein in serum-deprived murine fibroblasts Exp Cell Res 299 57 67 10.1016/j.yexcr.2004.05.024
25. R Trevisan L Daprai L Paloschi 2006 Antiapoptotic effect of human T-cell leukemia virus type 1 tax protein correlates with its creb transcriptional activity Exp Cell Res 312 1390 1400 10.1016/j.yexcr.2006.01.009
26. M Johannessen MP Delghandi U Moens 2004 What turns CREB on? Cell Signal 16 1211 1227 10.1016/j.cellsig.2004.05.001
27. DB Shankar JC Cheng KM Sakamoto 2005 Role of cyclic AMP response element binding protein in human leukemias Cancer 104 1819 1824 10.1002/cncr.21401
28. HC Lin M Hickey L Hsu D Medina AB Rabson 2005 Activation of human T cell leukemia virus type 1 LTR promoter and cellular promoter elements by T cell receptor signaling and HTLV-1 Tax expression Virology 339 1 11 10.1016/j.virol.2005.05.015
29. R Pozzatti J Vogel G Jay 1990 The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells Mol Cell Biol 10 413 417
30. AF Overbeck TR Brtva AD Cox 1995 Guanine nucleotide exchange factors: activators of Ras superfamily proteins Mol Reprod Dev 42 468 476 10.1002/mrd.1080420415
31. Y Yue J Lypowy N Hedhli 2004 Ras GTPase-activating protein binds to Akt and is required for its activation J Biol Chem 279 12883 12889 10.1074/jbc.M312308200
32. C Shih RA Weinberg 1982 Isolation of a transforming sequence from a human bladder carcinoma cell line Cell 29 161 169 10.1016/0092-8674(82)90100-3
33. D Saggioro M Forino A Penzo 1994 Tax-induced HTLV-I LTR transcriptional activation is modulated by phosphorylation Biochem Biophys Res Commun 205 666 673 10.1006/bbrc.1994.2717
34. SM Hanly LT Rimsky MH Malim 1989 Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements Genes Dev 3 1534 1544 10.1101/gad.3.10.1534
35. J Xing DD Ginty ME Greenberg 1996 Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase Science 273 959 963 10.1126/science.273.5277.959
36. MR Smith WC Greene 1990 Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes Genes Dev 4 1875 1885 10.1101/gad.4.11.1875
37. C Nicot R Harrod 2000 Distinct p300-responsive mechanisms promote caspase-dependent apoptosis by human T-cell lymphotropic virus type 1 Tax protein Mol Cell Biol 20 8580 8589 10.1128/MCB.20.22.8580-8589.2000
38. E Bossy-Wetzel L Bakiri M Yaniv 1997 Induction of apoptosis by the transcription factor c-Jun EMBO J 16 1695 1709 10.1093/emboj/16.7.1695
39. T Rosse R Olivier L Monney 1998 Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c Nature 391 496 499 10.1038/35160
40. D Saggioro S Barp L Chieco-Bianchi 2001 Block of a mitochondrial-mediated apoptotic pathway in Tax-expressing murine fibroblasts Exp Cell Res 269 245 255 10.1006/excr.2001.5310
41. MA Morgan T Sebil E Aydilek 2005 Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells Br J Haematol 130 912 925 10.1111/j.1365-2141.2005.05696.x
42. MD Houslay W Kolch 2000 Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling Mol Pharmacol 58 659 668
43. B Mayr M Montminy 2001 Transcriptional regulation by the phosphorylation-dependent factor CREB Nat Rev Mol Cell Biol 2 599 609 10.1038/35085068
44. T Uchiyama 1997 Human T cell leukemia virus type I (HTLV-I) and human diseases Annu Rev Immunol 15 15 37 10.1146/annurev.immunol.15.1.15
45. EW Harhaj L Good G Xiao 1999 Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation Oncogene 18 1341 1349 10.1038/sj.onc.1202405
46. K Chlichlia M Busslinger ME Peter 1997 ICE-proteases mediate HTLV-I Tax-induced apoptotic T-cell death Oncogene 14 2265 2272 10.1038/sj.onc.1201070
47. SY Kao FJ Lemoine SJ Mariott 2000 HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents Oncogene 19 2240 2248 10.1038/sj.onc.1203559
48. A Torgeman Z Ben-Aroya A Grunspan 2001 Activation of HTLV-I long terminal repeat by stress-inducing agents and protection of HTLV-I-infected T-cells from apoptosis by the viral tax protein Exp Cell Res 271 169 179 10.1006/excr.2001.5363
49. Y Kfoury R Nasr O Hermine 2005 Proapoptotic regimes for HTLV-I-transformed cells: targeting Tax and the NF-kappaB pathway Cell Death Differ 12 suppl 1 871 877 10.1038/sj.cdd.4401624
50. N Darwiche G Abou-Lteif A Bazarbachi 2007 Reactive oxygen species mediate N-(4-hydroxyphenyl)retinamide-induced cell death in malignant T cells and are inhibited by the HTLV-I oncoprotein Tax Leukemia 21 261 269 10.1038/sj.leu. 2404472
51. D Saggioro L Acquasaliente L Daprai 2003 Inhibition of apoptosis by human T-lymphotropic virus type-1 tax protein Ann N Y Acad Sci 1010 591 597 10.1196/annals.1299.111
52. YM Kim JA Ramirez JE Mick 2007 Molecular characterization of the tax-containing HTLV-1 enhancer complex reveals a prominent role for CREB phosphorylation in tax transactivation J Biol Chem 280 29653 29660
53. DB Shankar KM Sakamoto 2004 The role of cyclic-AMP binding protein (CREB) in leukemia cell proliferation and acute leukemias Leuk Lymphoma 45 265 270 10.1080/1042819031000151095
54. DB Shankar JC Cheng K Kinjo 2005 The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia Cancer Cell 7 351 362 10.1016/j.ccr.2005.02.018
55. TR Geiger N Sharma YM Kim 2008 The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB Mol Cell Biol 28 1383 1392 10.1128/MCB.01657-07
56. F Ehmann S Horn L Garcia-Palma 2006 Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations Leuk Lymphoma 47 1387 1391 10.1080/10428190600565925
57. W Kalas P Kisielow L Strzadala 2002 Inhibition of MEK induces fas expression and apoptosis in lymphomas overexpressing Ras Leuk Lymphoma 43 1469 1474 10.1080/1042819022386815