-
1
-
-
0031017711
-
Researchers seek new weapon against the flu
-
Service R.F. (1997) Researchers seek new weapon against the flu. Science 275 : 756 757.
-
(1997)
Science
, vol.275
, pp. 756-757
-
-
Service, R.F.1
-
2
-
-
0027287506
-
Rational design of potent sialidase-based inhibitors of influenza virus replication
-
Von Itzstein M., Wu W.Y., Kok G.B., Pegg M.S., Dyason J.C., Jin B., Phan T.V. et al. (1993) Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 363 : 418 423.
-
(1993)
Nature
, vol.363
, pp. 418-423
-
-
Von Itzstein, M.1
Wu, W.Y.2
Kok, G.B.3
Pegg, M.S.4
Dyason, J.C.5
Jin, B.6
Phan, T.V.7
-
3
-
-
58849128109
-
Efficacy of GS 4104 in ferrets infected with influenza a virus
-
Kim C.U., Bischofberger N., Williams M.A., Lew W., Merson J., Sweet C. (1997) Efficacy of GS 4104 in ferrets infected with influenza A virus. J Antiviral Res Soc A74 34.
-
(1997)
J Antiviral Res Soc A74
, pp. 34
-
-
Kim, C.U.1
Bischofberger, N.2
Williams, M.A.3
Lew, W.4
Merson, J.5
Sweet, C.6
-
4
-
-
0032710055
-
Zanamivir; A reviewof its use in influenza
-
Dunn C.J., Goa K.L. (1999) Zanamivir; a reviewof its use in influenza. Drugs 58 : 761.
-
(1999)
Drugs
, vol.58
, pp. 761
-
-
Dunn, C.J.1
Goa, K.L.2
-
5
-
-
0029998956
-
Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guan idino-Neu5Ac2en (GG167) with modified 5-substituents
-
Smith P.W., Starkey I.D., Howes P.D., Sollis S.L., Keeling S.P., Cherry P.C., von Itzstein M., Wu W.Y., Jin B. (1996) Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guan idino-Neu5Ac2en (GG167) with modified 5-substituents. J Med Chem 31 : 143 150.
-
(1996)
J Med Chem
, vol.31
, pp. 143-150
-
-
Smith, P.W.1
Starkey, I.D.2
Howes, P.D.3
Sollis, S.L.4
Keeling, S.P.5
Cherry, P.C.6
Von Itzstein, M.7
Wu, W.Y.8
Jin, B.9
-
6
-
-
58849105298
-
Zanamivir
-
Fromtling R.A. (2000) Zanamivir. Drugs Fut 25 : 430 433.
-
(2000)
Drugs Fut
, vol.25
, pp. 430-433
-
-
Fromtling, R.A.1
-
7
-
-
0029099621
-
Structure-based inhibitors of influenza virus sialidase a benzoic acid leads withnovel interaction
-
Singh S., Jedrzejas M.J., Air G.M., Luo M. (1995) Structure-based inhibitors of influenza virus sialidase A benzoic acid leads withnovel interaction. J Med Chem 38 : 3217 3225.
-
(1995)
J Med Chem
, vol.38
, pp. 3217-3225
-
-
Singh, S.1
Jedrzejas, M.J.2
Air, G.M.3
Luo, M.4
-
8
-
-
15144343348
-
Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design
-
Chand P., Babu Y.S., Bantia S., Chu N., Cole L.B., Kotian P.L. (1997) Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design. J Med Chem 40 : 4030 4052.
-
(1997)
J Med Chem
, vol.40
, pp. 4030-4052
-
-
Chand, P.1
Babu, Y.S.2
Bantia, S.3
Chu, N.4
Cole, L.B.5
Kotian, P.L.6
-
9
-
-
0032752856
-
4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase
-
Howes P.D., Cleasby A., Evans D.N., Feilden H., Smith P.W., Sollis S.L., Taylor N., Wonacott A.J. (1999) 4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase. J Med Chem 34 : 225 234.
-
(1999)
J Med Chem
, vol.34
, pp. 225-234
-
-
Howes, P.D.1
Cleasby, A.2
Evans, D.N.3
Feilden, H.4
Smith, P.W.5
Sollis, S.L.6
Taylor, N.7
Wonacott, A.J.8
-
10
-
-
0030800108
-
Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors
-
Williams M.A., Lew W., Mendel D.B., Tai C.Y., Escarpe P.A., Laver W.G., Stevens R.C., Kim C.U. (1997) Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors. J Am Chem Soc 7 : 1837 1842.
-
(1997)
J Am Chem Soc
, vol.7
, pp. 1837-1842
-
-
Williams, M.A.1
Lew, W.2
Mendel, D.B.3
Tai, C.Y.4
Escarpe, P.A.5
Laver, W.G.6
Stevens, R.C.7
Kim, C.U.8
-
11
-
-
58849144167
-
GS 4071 is a potent and selective inhibitor of the growth and neuraminidase activity of influenza a and B viruses
-
Mendel D.B., Tai C.Y., Escarpe P.A., Li W.X., Kim C.U., Williams M.A., Lew W., Zhang L., Bischofberger N., Huffman J.H. (1998) GS 4071 is a potent and selective inhibitor of the growth and neuraminidase activity of influenza A and B viruses. J Med Chem 41 : 2451 2460.
-
(1998)
J Med Chem
, vol.41
, pp. 2451-2460
-
-
Mendel, D.B.1
Tai, C.Y.2
Escarpe, P.A.3
Li, W.X.4
Kim, C.U.5
Williams, M.A.6
Lew, W.7
Zhang, L.8
Bischofberger, N.9
Huffman, J.H.10
-
12
-
-
0031916471
-
Identification of GS4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS4071
-
Li W.X., Escarpe P.A., Eisenberg E.J., Cundy K.C., Sweet C., Jakeman K.J., Merson J., Lew W., Williams M., Zhang L.J., Kim C.U., Bischofberger N., Chen M.S., Mendel D.B. (1998) Identification of GS4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS4071. Antimicrob Agents Chemother 42 : 647 653.
-
(1998)
Antimicrob Agents Chemother
, vol.42
, pp. 647-653
-
-
Li, W.X.1
Escarpe, P.A.2
Eisenberg, E.J.3
Cundy, K.C.4
Sweet, C.5
Jakeman, K.J.6
Merson, J.7
Lew, W.8
Williams, M.9
Zhang, L.J.10
Kim, C.U.11
Bischofberger, N.12
Chen, M.S.13
Mendel, D.B.14
-
13
-
-
58849151622
-
The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo
-
Ives J.A.L., Carr J.A., Mendel D.B., Tai C.Y., Lambkin R., Kelly L., Oxford J.S., Hayden F.G., Roberts N.A. (2002) The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo. JAMA 7 : 307 317.
-
(2002)
JAMA
, vol.7
, pp. 307-317
-
-
Ives, J.A.L.1
Carr, J.A.2
Mendel, D.B.3
Tai, C.Y.4
Lambkin, R.5
Kelly, L.6
Oxford, J.S.7
Hayden, F.G.8
Roberts, N.A.9
-
14
-
-
58849100272
-
Screening and synthesis of influenza neuraminidase inhibitors
-
Liu Z.Y., Wu Y.G., Li Z.R. (2002) Screening and synthesis of influenza neuraminidase inhibitors. Chin J Antibiot 27 : 529 531.
-
(2002)
Chin J Antibiot
, vol.27
, pp. 529-531
-
-
Liu, Z.Y.1
Wu, Y.G.2
Li, Z.R.3
-
15
-
-
0034008385
-
RWJ-270201
-
Sorbera L.A. (2000) RWJ-270201. Drugs Fut 25 : 249 251.
-
(2000)
Drugs Fut
, vol.25
, pp. 249-251
-
-
Sorbera, L.A.1
-
16
-
-
30344438548
-
A QSAR study on influenza neuraminidase inhibitors
-
Verma R.P., Hansch C. (2006) A QSAR study on influenza neuraminidase inhibitors. Bioorg Med Chem 14 : 982 996.
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 982-996
-
-
Verma, R.P.1
Hansch, C.2
-
17
-
-
0000970724
-
Molecular electronegative distance vector (MEDV) related to 15 properties of alkanes
-
Liu S.S., Cai S.C., Cao C.Z., Li Z.S. (2000) Molecular electronegative distance vector (MEDV) related to 15 properties of alkanes. J Chem Inf Comput Sci 40 : 1337 1348.
-
(2000)
J Chem Inf Comput Sci
, vol.40
, pp. 1337-1348
-
-
Liu, S.S.1
Cai, S.C.2
Cao, C.Z.3
Li, Z.S.4
-
18
-
-
0035848572
-
Design, synthesis and activity of substituted pyrrolidine influenza neuraminidase inhibitors
-
Zhao C., Maring C., Sun M., Stewart K., Stoll V., Xu Y., Gu Y. et al. (2001) Design, synthesis and activity of substituted pyrrolidine influenza neuraminidase inhibitors. J Med Chem 44 : 1192 1201.
-
(2001)
J Med Chem
, vol.44
, pp. 1192-1201
-
-
Zhao, C.1
Maring, C.2
Sun, M.3
Stewart, K.4
Stoll, V.5
Xu, Y.6
Gu, Y.7
-
19
-
-
0021095856
-
Protein folding by restrained energy minimization and molecular dynamics
-
Levitt M. (1983) Protein folding by restrained energy minimization and molecular dynamics. J Mol Biol 170 : 723 764.
-
(1983)
J Mol Biol
, vol.170
, pp. 723-764
-
-
Levitt, M.1
-
20
-
-
0024292833
-
Aromatic rings act as hydrogen bond acceptors
-
Levitt M., Perutz M.F. (1988) Aromatic rings act as hydrogen bond acceptors. J Mol Biol 201 : 751 754.
-
(1988)
J Mol Biol
, vol.201
, pp. 751-754
-
-
Levitt, M.1
Perutz, M.F.2
-
21
-
-
0035055493
-
Very empirical treatment of solvation and entropy; A force field derived from log Po/w
-
Kellogg G.E., Burnett J.C., Abraham D.J. (2001) Very empirical treatment of solvation and entropy; a force field derived from log Po/w. J Comput Aided Mol Des 15 : 381 393.
-
(2001)
J Comput Aided Mol des
, vol.15
, pp. 381-393
-
-
Kellogg, G.E.1
Burnett, J.C.2
Abraham, D.J.3
-
22
-
-
0026292147
-
HINT-a new method of empirical hydrophobic field calculation for CoMFA
-
Kellogg G.E., Semus S.F., Abraham D.J. (1991) HINT-a new method of empirical hydrophobic field calculation for CoMFA. J Comput Aided Mol Des 5 : 545 552.
-
(1991)
J Comput Aided Mol des
, vol.5
, pp. 545-552
-
-
Kellogg, G.E.1
Semus, S.F.2
Abraham, D.J.3
-
23
-
-
0029065636
-
Receptor surface models. 1. Definition and construction
-
Hahn M. (1995) Receptor surface models. 1. Definition and construction. Med Chem 38 : 2080 2090.
-
(1995)
Med Chem
, vol.38
, pp. 2080-2090
-
-
Hahn, M.1
-
24
-
-
0031551573
-
Hydropathic analysis of the non-covalent interactions between molecular subunits of structurally characterized hemoglobins
-
Abraham D.J., Kellogg G.E., Holt J.M., Ackers G.K. (1997) Hydropathic analysis of the non-covalent interactions between molecular subunits of structurally characterized hemoglobins. Mol Biol 272 : 613 632.
-
(1997)
Mol Biol
, vol.272
, pp. 613-632
-
-
Abraham, D.J.1
Kellogg, G.E.2
Holt, J.M.3
Ackers, G.K.4
-
25
-
-
0346500727
-
Hydropathic interaction analyses of small organic activators binding to antithrombin
-
Gunnarsson G.T., Umesh R.D. (2004) Hydropathic interaction analyses of small organic activators binding to antithrombin. Bioorg Med Chem 12 : 633 640.
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 633-640
-
-
Gunnarsson, G.T.1
Umesh, R.D.2
-
26
-
-
0001126839
-
New tools for modeling and understanding hydrophobicity and hydrophobic interactions
-
Kellogg G.E., Joshi G.S., Abraham D.J. (1992) New tools for modeling and understanding hydrophobicity and hydrophobic interactions. Med Chem Res 1 : 444 453.
-
(1992)
Med Chem Res
, vol.1
, pp. 444-453
-
-
Kellogg, G.E.1
Joshi, G.S.2
Abraham, D.J.3
-
27
-
-
0027080363
-
Complementary hydrophobicity map predictions of drug structure from a known receptor/receptor structure from known drugs
-
Kellogg G.E., Abraham D.J. (1992) Complementary hydrophobicity map predictions of drug structure from a known receptor/receptor structure from known drugs. Mol Graph 10 : 212 217.
-
(1992)
Mol Graph
, vol.10
, pp. 212-217
-
-
Kellogg, G.E.1
Abraham, D.J.2
-
28
-
-
0001308921
-
A rapid approximation to the solvent accessible surface areas of atoms
-
Hasel W., Hendrikson T.F., Still W.C. (1988) A rapid approximation to the solvent accessible surface areas of atoms. Tetrahedron Comp Method 1 : 103 116.
-
(1988)
Tetrahedron Comp Method
, vol.1
, pp. 103-116
-
-
Hasel, W.1
Hendrikson, T.F.2
Still, W.C.3
-
29
-
-
10344264422
-
Estimating protein-ligand binding free energy; Atomic solvation parameters for partition coefficient and solvation free energy calculation
-
Pei J., Wang Q., Zhou J., Lai L. (2004) Estimating protein-ligand binding free energy; atomic solvation parameters for partition coefficient and solvation free energy calculation. Proteins 57 : 651 664.
-
(2004)
Proteins
, vol.57
, pp. 651-664
-
-
Pei, J.1
Wang, Q.2
Zhou, J.3
Lai, L.4
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