Induction of mucosal and systemic antibody specific for SeMF3 of Streptococcus equi by intranasal vaccination using a sucrose acetate isobutyrate based delivery system

Vaccine

Volumn 19, Issue 4-5, 2000, Pages 492-497

  Nally, Jarlath E ^a   Artiushin, Sergey ^a   Sheoran, Abhineet S ^a   Burns, Patrick J ^b   Simon, Barry ^b   Gilley, Richard M ^b   Gibson, J ^c   Sullivan, S ^c   Timoney, John F ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Thorn BioScience LLC   (United States)

^c Southern BioSystems Inc   (United States)

Author keywords

Equine immunoglobulin; Intranasal immunization; Sucrose acetate isobutyrate

Indexed keywords

BACTERIAL ANTIGEN; IMMUNOGLOBULIN A; INACTIVATED VACCINE; SUCROSE ACETATE ISOBUTYRATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HORSE; IMMUNOGENICITY; IMMUNOGLOBULIN PRODUCTION; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS EQUI; VACCINATION;

ADMINISTRATION, INTRANASAL; AMINO ACID SEQUENCE; ANIMAL; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL VACCINES; DRUG DELIVERY SYSTEMS; FEMALE; HORSE DISEASES; HORSES; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MOLECULAR SEQUENCE DATA; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS EQUI; SUCROSE; SUPPORT, NON-U.S. GOV'T; VACCINES, SYNTHETIC;

EID: 0034668159     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00187-0     Document Type: Article

References (17)

1. Timoney J.F., Artiushin S., Boschwitz J.S. Comparisons of the sequences and functions of Streptococcus equi M-Like proteins SeM and SzPSe. Infect. Immun. 65:(9):1997;3600-3605.
2. Boschwitz J.F., Timoney J.F. Inhibition of C3 deposition on Streptococcus equi subsp. equi by SeM: a mechanism of survival in equine blood. Infect. Immun. 62:1994;3515-3520.
3. Boschwitz J.S., Timoney J.F. Characterization of the antiphagocytic activity of equine fibrinogen for Streptococcus equi subsp. equi. Microb. Pathog. 17:1994;121-129.
4. Timoney J.F., Guan M. Characterization of murine monoclonal antibodies recognizing opsonic, mouse-protective, chaining and mucosally relevant epitopes on the M protein of Streptococcus equi subspecies equi. Res. Vet. Sci. 60:1996;76-81.
5. Timoney J.F., Artiushin S., Wang J. Regions of the protective M-like protein of Streptococcus equi recognized by serum and mucosal antibodies of convalescent horses. Equine infectious disease VIII. Proceedings of the 8th International conference. 1999;88-94 R&W Publications, Newmarket.
6. Galan JE, Timoney JF. Mucosal nasopharyngeal immune responses of horses to protein antigens of Streptococcus equi. Infect Immun 1985;(47):623-8.
7. Galan J.E., Timoney J.F., Lengemann F.W. Passive transfer of mucosal antibody in Streptococcus equi in the foal. Infect. Immun. 54:(1):1986;202-206.
8. Hamlen H.J., Timoney J.F., Bell R.J. Epidemiologic and immunologic characteristics of Streptococcus equi infection in foals. J. Am. Vet. Med. Assoc. 204:1994;768-775.
9. Sheoran AS, Sponseller BT, Holmes MA, Timoney JF. Serum and mucosal antibody isotype responses to M-like protein (SeM) of Streptococcus equi in convalescent and vaccinated horses. Vet Immunol Immunopathol 1997;(59):239-51.
10. Sheoran A.S., Lunn D.P., Holmes M.A. Monoclonal antibodies to subclass-specific antigenic determinants on equine immunoglobulin gamma chains and their characterization. Vet. Immunol. Immunopathol. 62:1998;153-165.
11. Lunn D.P., Holmes M.A., Antczak D.F., et al. Report of the second equine leucocyte antigen workshop. Vet. Immunol. Immunopathol. 42:1998;3-60.
12. Lunn D.P., Hannant D., Horohov D.W. Immunology of horses and donkeys. Pastoret P.P., Bazin H., Griebel P., Govaerts H. Handbook of vertebrate immunology. 1998;343-371 Academic Press, London.
13. Sheoran AS, Holmes MA, Karzenski SS, Crismann MV, Timoney JF. Immunoglobulin isotypes in equine sera and nasal mucosal secretions and their neonatal transfer and distribution. Am J Vet Res 1999, in press.
14. Bouvet J-P, Fischetti VA. Diversity of antibody-mediated immunity at the mucosal barrier. Infect Immun 1999;(67):2687-91.
15. Nelson K.M., Schram B.R., McGregor M.W., Sheoran A.S., Olsen C.W., Lunn D.P. Local and systemic isotype-specific antibody responses to equine influenza virus infection versus conventional vaccination. Vaccine. 16:(13):1998;1306-1313.
16. Berneman A., Belec L., Fischetti V.A., Bouvet J.P. The specificity patterns of human immunoglobulin G antibodies in serum differ from those in autologous secretions. Infect. Immun. 66:1998;4163-4168.
17. McGuire TC, Crawford TW, Henson JB. The isolation, characterization and functional properties of equine immunoglobulin classes and subclasses. In: Bryans JT, Gerber H, editors. Proceedings of the 3rd International Conference on Equine Infectious Diseases. Paris, Basel: Karger, 1973, pp 364-81.