Disruption of period gene expression alters the inductive effects of dioxin on the AhR signaling pathway in the mouse liver

Toxicology and Applied Pharmacology

Volumn 234, Issue 3, 2009, Pages 370-377

  Qu, Xiaoyu ^a   Metz, Richard P ^b   Porter, Weston W ^b   Cassone, Vincent M ^a   Earnest, David J ^a,c  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

AhR nuclear translocator; Aryl hydrocarbon receptor; Circadian rhythms; Clock genes; Cytochrome p450 enzymes; Hepa1c1c7; PAS genes; Period1; Period2; Polycyclic aromatic hydrocarbons; siRNA; Xenobiotics

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DIOXIN; PER1 PROTEIN; PER2 PROTEIN; SMALL INTERFERING RNA;

ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HEPA1C1C7; CONTROLLED STUDY; FEMALE; GENE DISRUPTION; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENOTYPE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; CARCINOGENS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; ENZYME INDUCTION; FEMALE; LIVER; MICE; MICE, TRANSGENIC; NUCLEAR PROTEINS; RECEPTORS, ARYL HYDROCARBON; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA; MUS;

EID: 58649115609     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.10.016     Document Type: Article

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