Activated Notch Supports Development of Cytokine Producing NK Cells Which Are Hyporesponsive and Fail to Acquire NK Cell Effector Functions

Biology of Blood and Marrow Transplantation

Volumn 15, Issue 2, 2009, Pages 183-194

  Bachanova, Veronika ^a   McCullar, Valarie ^a   Lenvik, Todd ^a   Wangen, Rosanna ^a   Peterson, Karen A ^a   Ankarlo, Dave E M ^a   Panoskaltsis Mortari, Angela ^a   Wagner, John E ^a   Miller, Jeffrey S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Lymphocyte development; Lymphopoiesis; NK cells; Notch

Indexed keywords

CD3 ANTIGEN; CD7 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 2; L SELECTIN; NATURAL KILLER CELL RECEPTOR; NOTCH1 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE HOMING; NATURAL KILLER CELL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STROMA CELL; TH1 CELL; UMBILICAL CORD BLOOD;

ANIMALS; ANTIGENS, CD7; CELL CULTURE TECHNIQUES; CELL LINEAGE; CHEMOKINES; COCULTURE TECHNIQUES; CYTOKINES; FETAL BLOOD; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNITY; KILLER CELLS, NATURAL; LYMPHOPOIESIS; MICE; RECEPTOR, NOTCH1; STROMAL CELLS;

EID: 58649111267     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2008.11.031     Document Type: Article

References (49)

1. Lanier L.L., Corliss B., and Phillips J.H. Arousal and inhibition of human NK cells. Immunol Rev 155 (1997) 145-154
2. Blom B., and Spits H. Development of human lymphoid cells. Annu Rev Immunol 24 (2006) 287-320
3. Miller J.S., and McCullar V. Human natural killer cells with polyclonal lectin and immunoglobulin-like receptors develop from single hematopoietic stem cells with preferential expression of NKG2A and KIRL2/L3/S2. Blood 98 (2001) 705-713
4. Parham P. Talking license with natural killer cell maturation and repertoire development. Immun Rev 214 (2006) 155-160
5. Cooley S., Xiao F., Pitt M., et al. 2007. A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self MHC is developmentally immature. Blood 110 (2007) 578-586
6. Cooper M.A., Fehniger T.A., Turner S.C., et al. Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset. Blood 97 (2001) 3146-3151
7. Frey M., Packianathan N.B., Fehniger T.A., et al. Differential expression and function of L-selectine on CD56bright and CD56dim natural killer cell subsets. J Immunol 161 (1998) 400-408
8. bright natural killer cells. Immunity 22 (2005) 295-304
9. Nguyen S., Dhedin N., Vernant J.P., et al. NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect. Blood 105 (2005) 4135-4142
10. Shilling H.G., McQueen K.L., Cheng N.W., et al. Reconstitution of NK cell receptor repertoire following HLA-matched hematopoietic cell transplantation. Blood 101 (2003) 3730-3740
11. Cooley S., McCullar V., Wangen R., et al. KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation. Blood 106 (2005) 4370-4376
12. Miller J.S., Alley K.A., and McGlave P. Differentiation of natural killer (NK) cells from human primitive marrow progenitors in stroma-based long-term culture system: identification of CD34+CD7+ NK progenitor. Blood 83 (1994) 2594-2601
13. Mrozek E., Anderson P., and Caligiuri M.A. Role of interleukin 15 in the development of human CD56+ natural killer cells from CD34+ hematopoetic progenitor cells. Blood 87 (1996) 2632-2640
14. Lotzova E., Savary C.A., and Champlin R.E. Genesis of human oncolytic natural killer cells from primitive CD34+CD33- bone marrow progenitors. J Immunol 150 (1993) 5263-5269
15. Miller J.S., Verfaille C., and McGlave P. The generation of natural killer cells from CD34+/DR- primitive progenitors in human long-term bone marrow culture. Blood 80 (1992) 2182-2187
16. Hackett J., Bennett M., and Kumar V. Origin and differentiation of natural killer cells. Characteristics of transplantable NK cell precursor. J Immunol 134 (1985) 3731-3738
17. Miller J.S., McCullar V., Punzel M., Lemischka I.R., and Moore K.A. Single adult human CD34(+)/Lin-/CD38(-) progenitors give rise to natural killer cells, B-lineage cells, dendritic cells, and myeloid cells. Blood 93 (1999) 96-106
18. McCullar V., Oostendorp R., Panoskaltsis-Mortari A., et al. Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15. Exp Hematol 36 (2008) 598-608
19. Stier S., Cheng T., Dombkowski D., Carlesso N., and Scadden D.T. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage commitment. J Exp Med 192 (2000) 1775-1784
20. Varnum-Finney B., Brashem-Stein C., and Bernstein I.D. Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood 101 (2003) 1784-1789
21. Jaleco A.C., Neves H., Hooijberg E., et al. 2001. Differential effect of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J Exp Med 194 (2001) 991-1001
22. De Smedt M., Taghon T., Van de Walle I., DeSmet G., leclercq G., and Plum J. Notch signaling induced cytoplasmic CD3ε{lunate} expression in human differentiating NK cells. Blood 110 (2007) 2696-2703
23. Carotaa S., Brady J., Wu L., and Nutt S.E. Transient Notch signaling induces NK cells potential in Pax5-deficient pro-B cells. Eur J Immunol 36 (2006) 1-11
24. Varnum-Finney B., Purton L.E., Yu M., et al. The Notch ligand, Jagged 1, influence the development of primitive hematopoietic precursor cells. Blood 91 (1998) 4084-4091
25. Radtke F., Wilson A., Ernst B., and McDonald H.R. The role of Notch signaling during hematopoetic lineage commitment. Immunol Rev 187 (2002) 65-74
26. Garcia-Peydro M., de Yebenes V.G., and Toribio M.L. Sustained Notch 1 signaling instructs the earliest human intrathymic precursors to adopt a γδ T cell fate in human fetal thymus organ culture. Blood 102 (2003) 2444-2451
27. Bray S., and Furrols M. Notch pathway: making sense of suppressor of hairless. Curr Biol 11 (2001) R217-R221
28. Aster J.C., Xu L., Karnell F.G., Patriub V., Pui J.C., and Pear W.S. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol Cell Biol 20 (2000) 7505-7515
29. Naviaux R.K., Costanzi E., Haas M., and Verma I.M. The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J Virol 70 (1996) 5701-5705
30. Chiorean E.G., Dylla S.J., Olsen K., Lenvik T., Soignier Y., and Miller J.S. BCR/ABL alters the function of NK cells and the aqcuisition of killer immunoglobulin-like receptors (KIR). Blood 101 (2003) 3527-3533
31. +dim natural killer cells in patients with chronic myelogenous leukemia progressively decrease in number, respond less to stimuli that recruit clonogenic natural killer cells, and exhibit decreased proliferation on a per cell basis. Blood 88 (1996) 2279-2287
32. Grzywacz B., Kataria N., Sikora M., et al. Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells. Blood 108 (2006) 3824-3833
33. Freud A.G., Yokohama A., Becknell B., et al. Evidence for discrete stages of human natural killer cell differentiation in vivo. J Exp Med 203 (2006) 1033-1043
34. Smyth M.J., Cretney E., Kelly J.M., et al. Activation of NK cell cytotoxicity. Mol Immunol 42 (2001) 501-510
35. Cooper M.A., Fehniger T.A., and Caliguiri M.A. The biology of human killer subset. Trends Immunol 22 (2001) 633-640
36. Loza M.J., Zamai L., Zamai L., Azzoni L., Rosati E., and Perussia B. Expression of type 1 (IFNγ)and type 2 (IL-13, IL-5) cytokines at distinct stages of NK cell differentiation from progenitor cells. Blood 99 (2002) 1273-1281
37. bright NK cells. J Leukoc Biol 80 (2006) 1529-1541
38. Ferlazzo G., Thomas D., Lin S.L., et al. 2004. The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic. J Immunol 172 (2004) 1455-1462
39. Aoyama K., Delaney C., Varnum-Finney B., Kohn A.D., Moon R.T., and Bernstein I.D. The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation. Stem Cells 25 (2007) 2488-2497
40. Vosshenrich C.A., Garcia-Ojeda M.E., and Samson Villeger S.E. A thymic pathway of mouse natural killer cell development is characterized by expression of GATA-3 and CD127. Nat Immunol 7 (2006) 1217-1224
41. Di Santo J.P., and Vosshenrich C.A. Bone marrow versus thymic pathways of natural killer cell development. Immunol Rev 214 (2006) 35-46
42. Sander G.R., and Powell B.C. Expression of notch receptors and ligands in the adult gut. J Histochem Cytochem 52 (2004) 509-516
43. Parham P. Talking license with natural killer cell maturation and repertoire development. Immun Rev 214 (2006) 155-160
44. De Smedt M., Hoebeke I., Reynvoet K., Leclercq G., and Plum J. Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic, or T-cell lineage in thymus microenvironment. Blood 106 (2005) 3498-3506
45. Rothenberg E.V., Diamond R.A., Pepper K.A., and Yang J.A. 1990. IL-2 Gene inducibility in T cells before T cell receptor expression. Changes in signaling pathways and gene expression requirements during intrathymic maturation. J Immunol 144 (1990) 1614-1624
46. Ohishi K., Varnum-Finney B., and Bernstein I.D. Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38- cord blood cells. J Clin Invest 110 (2002) 1165-1174
47. Ohishi O., Varnum-Finney B., Serda R.E., Anasetti C., and Bernstein I.D. The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells. Blood 98 (2001) 1402-1407
48. La Motte-Mohs R.N., Herer E., and Zuniga-Pflucker J.C. Induction of T cell development from human cord blood hematopoetic stem cells by Delta-like 1 in vitro. Blood 105 (2005) 1432-1439
49. Lynch L., O'Donoghue D., Dean J., O'Sullivan J., O'Farrelly C., and Golden-Mason L. Detection and characterization of hematopoetic stem cells in the adult human intestine. J Immunol 76 (2006) 5199-5204