Evaluation of ovotoxicity induced by 7, 12-dimethylbenz[a]anthracene and its 3,4-diol metabolite utilizing a rat in vitro ovarian culture system

Toxicology and Applied Pharmacology

Volumn 234, Issue 3, 2009, Pages 361-369

  Igawa, Yoshiyuki ^a,b   Keating, Aileen F ^a   Rajapaksa, Kathila S ^a,c   Sipes, I Glenn ^a   Hoyer, Patricia B ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b DAIICHI SANKYO CO   (Japan)

^c AMGEN INC   (United States)

Author keywords

Dimethylbenz a anthracene; Microsomal epoxide hydrolase; Ovotoxicity

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; 7,12 DIMETHYLBENZ[A]ANTHRACENE 3,4 DIOL; 7,12 DIMETHYLBENZ[A]ANTHRACENE 3,4 DIOL 1,2 EPOXIDE; CYCLOHEXANE OXIDE; EPOXIDE HYDROLASE; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; B6C3F1 MOUSE; CATALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG ACTIVITY; DRUG EXPOSURE; FEMALE; FISCHER 344 RAT; HISTOPATHOLOGY; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY; OVARY CELL CULTURE; OVARY FOLLICLE; OVOTOXICITY; PERINATAL PERIOD; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANIMALS, NEWBORN; BENZ(A)ANTHRACENES; BIOTRANSFORMATION; CYCLOHEXENES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ENZYME INHIBITORS; EPOXIDE HYDROLASES; FEMALE; OVARIAN FOLLICLE; OVARY; RATS; RATS, INBRED F344; RNA, MESSENGER; TIME FACTORS; TISSUE CULTURE TECHNIQUES;

MUS; RATTUS;

EID: 58649100043     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.10.009     Document Type: Article

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