Effect of CYP2E1 gene deletion in mice on expression of microsomal epoxide hydrolase in response to VCD exposure

Toxicological Sciences

Volumn 105, Issue 2, 2008, Pages 351-359

  Keating, Aileen F ^a   Rajapaksa, Kathila S ^a,b   Sipes, I Glenn ^a   Hoyer, Patricia B ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b AMGEN INC   (United States)

Author keywords

Cytochrome P450 isoform 2E1; Microsomal epoxide hydrolase; VCD induced ovotoxicity

Indexed keywords

4 VINYLCYCLOHEXENE DIEPOXIDE; COMPLEMENTARY DNA; CYTOCHROME P450 2E1; DIMETHYLBENZ[A]ANTHRACENE; EPOXIDE HYDROLASE; INDUSTRIAL CHEMICAL; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DETOXIFICATION; DNA SYNTHESIS; FEMALE; GENE DELETION; GENOTYPE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; METABOLITE; MOUSE; NONHUMAN; OVARY FOLLICLE; PROTEIN EXPRESSION; PROTEIN ISOLATION; REPRODUCTIVE TOXICITY; RNA ISOLATION; TISSUE CULTURE; WESTERN BLOTTING;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANIMALS, NEWBORN; CYCLOHEXENES; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXIDE HYDROLASES; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MICE; MICE, KNOCKOUT; ORGAN CULTURE TECHNIQUES; OVARIAN FOLLICLE; OVARY; RNA, MESSENGER; TIME FACTORS; VINYL COMPOUNDS;

MUS; RODENTIA;

EID: 51849142786     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn136     Document Type: Article

References (31)

1. Akiyama, T. E., and Gonzalez, F. J. (2003). Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. Biochim. Biophys. Acta. 1619,223-234.
2. Borman, S. M., Christian, P. J., Sipes, I. G., and Hoyer, P. B. (2000). Ovotoxicity, in female fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: Comparison through calculation of an ovotoxic index. Toxicol. Appl. Pharmacol. 167 191-198.
3. Cannady, E. A., Dyer, C. A., Christian, P. J., Sipes, I. G., and Hoyer, P. B. (2002). Expression and activity of microsomal epoxide hydrolase in follicles isolated from mouse ovaries. Toxicol. Sci. 68, 24-31.
4. Cannady, E. A., Dyer, C. A., Christian, P. J., Sipes, I. G., and Hoyer, P. B. (2003). Expression and activity of cytochrome P450 2E1, 2A, and 2B in the mouse ovary: The effect of 4-vinylcyclohexene and its diepoxide metabolite. Toxicol. Sci. 73, 423-430.
5. Devine, P. J., Rajapaksa, K. S., and Hoyer, P. B. (2002a). In vitro ovarian tissue and organ culture: A review. Front. Biosci. 7 1979-1989.
6. Devine, P. J., Sipes, I. G., Skinner, M. K., and Hoyer, P. B. (2002b). Characterization of a rat in vitro ovarian culture system to study the ovarian toxicant 4-vinylcyclohexene diepoxide. Toxicol. Appl. Pharmacol. 184, 107-115.
7. Gong, P., and Cederbaum, A. I. (2006). NRF2 is increased in CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1. Hepatology 43, 114-153.
8. Flaws, J. A., Doerr, J. K., Sipes, I. G., and Hoyer, P. B. (1994). Destruction of preantral follicles in adult rats by 4-vinyl-1-cyclohexene diepoxide. Reprod. Toxicol 8, 509-514.
9. Hirshfield, A. N. (1991). Development of follicles in the mammalian ovary. Int. Rev. Cytol. 124, 43-101.
10. Hu, X., Christian, P. J., Sipes, I. G., and Hoyer, P. B. (2001a). Expression and redistribution of cellular Bad, Bax, and Bcl-X(L) protein is associated with VCD-induced ovotoxicity in rats. Biol. Reprod. 65, 1489-1495.
11. Hu, X., Christian, P. J., Thompson, K. E., Sipes, I. G., and Hoyer, P. B. (2001b). Apoptosis induced in rats by 4-vinylclohexene diepoxide is associated with activation of the caspase cascades. Biol. Reprod. 65, 87-93.
12. Hu, X., Flaws, J. A., Sipes, I. G., and Hoyer, P. B. (2002). Activation of mitogen-activated protein kinases and AP-1 transcription factor in ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats. Biol. Reprod. 67, 718-724.
13. Hu, X., Roberts, J. R., Apopa, P. L., Kan, Y. W., and Ma, Q. (2006). Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. Mol. Cell Biol. 26, 940-954.
14. International Agency for Research on Cancer (LARC). (I 994).4-Vinylcyclohexene. IARC monographs on the evaluation of carcinogenic risks to humans: Some industrial chemicals. 60, p. 347. IARC Press, Lyon, France.
15. Kao, S. W., Sipes, L G., and Hoyer, P. B. (1999). Early effects induced by 4-vinylcyclohexene diepoxide in rats and mice. Reprod. Toxicol 13, 67-75.
16. 1 mice. Toxicol. Appl. Pharmacol. 230, 109-16.
17. Keller, D. A., Carpenter, S. C., Cagen, S. Z., and Reitman, F. A. (1997). In vitro metabolism of 4-vinylcyclohexene in rat and mouse liver, lung, and ovary. Toxicol. Appl. Pharmacol. 144, 36-44.
18. Kim, S. K., and Novak, R. F. (2007). The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. Pharmacol. Ther. 113, 88-120.
19. Matikainen, T., Perez, G. I., Jurisicova, A., Pru, J. K., Schlezinger, J. J., Ryu, H., Laine, J., Sakai, T., Korsmeyer, S., Casper, R., et al. (2001). Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazard environmental chemicals. Nat. Genet. 28, 355-360.
20. Miyata, M., Judo, G., Lee, Y., Yang, T. J., Gelboni, H. V., Fernandez-Saiguero, P., Kimura, S., and Gonzalez, F. J. (1999). Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene. J. Biol. Chem. 274, 23963-23968.
21. Omiecinski, C. J., Hassett, C., and Hosagrahara, V. (2000). Epoxide hydrolasepolymorphism and role in toxicology. Toxicol. Lett. 112-113, 365-370.
22. Parrott, J. A., and Skinner, M. K. (1999). Kit-ligand/stern cell factor induces primordial follicle development and initiates folliculogenesis. Endocrinology 140, 4262-4271.
23. Pedersen, T., and Peters, H. (1968). Proposal for a classification of oocytes and follicles in the mouse ovary. J. Reprod. Fertil. 17 555-557.
24. Rajapaksa, K. S., Cannady, E. A., Sipes, I. G., and Hoyer, P. B. (2007a). Involvement of CYP 2E1 enzyme in ovotoxicity caused by 4-vinylcyclohexene and its metabolites. Toxicol. Appl. Pharmacol. 221, 215-221.
25. Rajapaksa, K. S., Sipes, I. G., and Hoyer, P. B. (2007b). Involvement of microsomal epoxide hydrolase in ovotoxicity caused by 7,12-dimethylbenz (a)anthracene. Toxicol. Sci. 96, 327-334.
26. Sekine, S., Lan, B. Y., Bedolli, M., Feng, S., and Hebrok, M. (2006). Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome P450 expression in mice. Hepatology 43 817-825.
27. Shiromizu, K., and Mattison, D. R. (1985). Murine oocyte destruction following intraovarian treatment with 3-methylcholanthrene or 7,12-dimethyllbenz(a)anthracene: Protection by alpha-naphthoflavone. Teratog. Carcinog. Mutagen 5, 463-472.
28. Smith, B. J., Mattison, D. R., and Sipes, I. G. (1990). The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity. Toxicol. Appl. Pharmacol. 105, 372-381.
29. Springer, L. N., McAsey, M. E., Flaws, J. A., Tilly, J. L., Sipes, I. G., and Hoyer, P. B. (1996a). Involvement of apoptosis in 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats. Toxicol. Appl. Pharmacol. 139, 394-401.
30. Springer, L. A., Tilly, J. L., Sipes, I. G., and Hoyer, P. B. (1996b). Enhanced expression of bax in small preantral follicles during 4-vinylcyclohexene diepoxide-induced ovotoxicity in the rat. Toxicol. Appl. Pharmacol. 139, 402-410.
31. Thompson, K. E., Bourguet, S. M., Christian, P. J., Benedict, J. C., Sipes, I. G., Flaws, J. A., and Hoyer, P. B. (2005). Differences between rats and mice in the involvement of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss. Toxicol. Appl. Pharmacol. 203, 114-123.