Long-term feeding of the cis-9,trans-11 isomer of conjugated linoleic acid reinforces the specific immune response in rats

Journal of Nutrition

Volumn 139, Issue 1, 2009, Pages 76-81

  Ramírez Santana, Carolina ^a   Castellote, Cristina ^a,b   Castell, Margarida ^a   Rivero, Montserrat ^c   Rodríguez Palmero, Maria ^c   Franch, Àngels ^a,b   Pérez Cano, Francisco J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^c Research and Conservation Department   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CONJUGATED LINOLEIC ACID; IMMUNOGLOBULIN A; INTERLEUKIN 2; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; FOOD INTAKE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; MESENTERY LYMPH NODE; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN SECRETION; RAT; SPLEEN CELL; WISTAR RAT;

ANIMALS; DIET; FEMALE; IMMUNITY, CELLULAR; IMMUNOGLOBULINS; LINOLEIC ACIDS, CONJUGATED; OVALBUMIN; RATS; RATS, WISTAR; SPLEEN; WEIGHT GAIN;

RATTUS; RATTUS NORVEGICUS;

EID: 58649091752     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.097428     Document Type: Article

References (43)

1. Meade CJ, Mertin J. Fatty acids and immunity. Adv Lipid Res. 1978;16:127-65.
2. Miles EA, Calder PC. Modulation of immune function by dietary fatty acids. Proc Nutr Soc. 1998;57:277-92.
3. Yaqoob P. Fatty acids and the immune system: from basic science to clinical applications. Proc Nutr Soc. 2004;63:89-104.
4. Yaqoob P, Calder PC. Fatty acids and immune function: new insights into mechanisms. Br J Nutr. 2007;98:S41-5.
5. Calder PC. Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Mol Nutr Food Res. 2008;5:885-97.
6. Ha YL, Grimm NK, Pariza MW. Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcinogenesis. 1987; 8:1881-7.
7. Ip C, Jiang C, Thompson HJ, Scimeca JA. Retention of conjugated linoleic acid in the mammary gland is associated with tumor inhibition during the post-initiation phase of carcinogenesis. Carcinogenesis. 1997; 18:755-9.
8. Kelley NS, Hubbard NE, Erickson KL. Conjugated linoleic acid isomers and cancer. J Nutr. 2007;137:2599-607.
9. Nicolosi RJ, Rogers EJ, Kritchevsky D, Scimeca JA, Huth PJ. Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery. 1997;22: 266-77.
10. Houseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, Portocarrero CP, Peck LW, Nickel KP, Belury MA. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun. 1998;244:678-82.
11. Taylor CG, Zahradka P. Dietary conjugated linoleic acid and insulin sensitivity and resistance in rodent models. Am J Clin Nutr. 2004;79: S1164-8.
12. Park Y, Pariza MW. Mechanisms of body fat modulation by conjugated linoleic acid (CLA). Food Res Int. 2007;40:311-23.
13. Li Y, Watkins BA. Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n-6 or n-3 fatty acids. Lipids. 1998;33:417-25.
14. Riserus U, Arner P, Brismar K, Vessby B. Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care. 2002;25:1516-21.
15. Kelley DS, Erickson KL. Modulation of body composition and immune cell functions by conjugated linoleic acid in humans and animal models: benefits vs. risks. Lipids. 2003;38:377-86.
16. Pariza MW, Park Y, Cook ME. The biologically active isomers of conjugated linoleic acid. Prog Lipid Res. 2001;40:283-98.
17. O'Shea M, Bassaganya-Riera J, Mohede IC. Immunomodulatory properties of conjugated linoleic acid. Am J Clin Nutr. 2004;79: S1199-206.
18. Terpstra AH. Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. Am J Clin Nutr. 2004;79:352-61.
19. Sugano M, Tsujita A, Yamasaki M, Noguchi M, Yamada K. Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats. Lipids. 1998;33:521-7.
20. Brandtzaeg P, Johansen FE. Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties. Immunol Rev. 2005;206:32-63.
21. Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui Y, Hennighausen L, Gonzalez F, Rohrer J, Benninghoff AU, Hontecillas R. Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology. 2004;127:777-91.
22. Frazier AL, Ryan CT, Rockett H, Willett WC, Colditz GA. Adolescent diet and risk of breast cancer. Breast Cancer Res. 2003;5:R59-64.
23. Luna P, Juarez M, Angel de la Fuente M. Fatty acid and conjugated linoleic acid isomer profiles in human milk fat. Eur J Lipid Sci Technol. 2007;109:1160-6.
24. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
25. Pérez-Cano FJ, Castellote C, Marín-Gallén S, González-Castro A, Franch À, Castell M. Phenotypic and functional characteristics of rat spleen lymphocytes during suckling. Dev Comp Immunol. 2007;31: 1264-77.
26. Péirez-Berezo T, Ramiro-Puig E, Péirez-Cano FJ, Castellote C, Permanyer J, Franch A, Castell M. Influence of a cocoa-enriched diet on specific immune response in ovalbumin-sensitized rats. Mol Nutr Food Res. 2009;53: In press DOI 10.1002/mnfr.200700396.
27. Novelli EL, Diniz YS, Galhardi CM, Ebaid GM, Rodrigues HG, Mani F, Fernandes AA, Cicogna AC, Novelli Filho JL. Anthropometrical parameters and markers of obesity in rats. Lab Anim. 2007;41:111-9.
28. Turpeinen AM, von Willebrand E, Salminen I, Linden J, Basu S, Rai D. Effects of cis-9,trans-11 CLA in rats at intake levels reported for breastfed infants. Lipids. 2006;41:669-77.
29. Calder PC, Yaqoob P, Thies F, Wallace FA, Miles EA. Fatty acids and lymphocyte functions. Br J Nutr. 2002;87:S31-48.
30. Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Grimble RF, Williams CM, Calder PC, Yaqoob P. Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am J Clin Nutr. 2004;80:1626-33.
31. Albers R, van der Wielen RP, Brink EJ, Hendriks HF, Dorovska-Taran VN, Mohede IC. Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. Eur J Clin Nutr. 2003;57:595-603.
32. Hayek MG, Han SN, Wu D, Watkins BA, Meydani M, Dorsey JL, Smith DE, Meydani SN. Dietary conjugated linoleic acid influences the immune response of young and old C57BL/6NCrlBR mice. J Nutr. 1999;129:32-8.
33. Kelley DS, Taylor PC, Rudolph IL, Benito P, Nelson GJ, Mackey BE, Erickson KL. Dietary conjugated linoleic acid did not alter immune status in young healthy women. Lipids. 2000;35:1065-71.
34. Bassaganya-Riera J, Hontecillas R, Zimmerman DR, Wannemuehler MJ. Long-term influence of lipid nutrition on the induction of CD8(1) responses to viral or bacterial antigens. Vaccine. 2002;20:1435-44.
35. Bassaganya-Riera J, Pogranichniy RM, Jobgen SC, Halbur PG, Yoon KJ, O'Shea M, Mohede I, Hontecillas R. Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immuno- suppression. J Nutr. 2003;133:3204-14.
36. Kelley DS, Simon VA, Taylor PC, Rudolph IL, Benito P, Nelson GJ, Mackey BE, Erickson KL. Dietary supplementation with conjugated linoleic acid increased its concentration in human peripheral blood mononuclear cells, but did not alter their function. Lipids. 2001;36:669-74.
37. Jaudszus A, Krokowski M, Mockel P, Darcan Y, Avagyan A, Matricardi P, Jahreis G, Hamelmann E. Cis-9,trans-11-conjugated linoleic acid inhibits allergic sensitization and airway inflammation via a PPARγ- related mechanism in mice. J Nutr. 2008;138:1336-42.
38. Kelley DS, Warren JM, Simon VA, Bartolini G, Mackey BE, Erickson KL. Similar effects of c9,t11-CLA and t10,c12-CLA on immune cell functions in mice. Lipids. 2002;37:725-8.
39. Song HJ, Grant I, Rotondo D, Mohede I, Sattar N, Heys SD, Wahle KW. Effect of CLA supplementation on immune function in young healthy volunteers. Eur J Clin Nutr. 2005;59:508-17.
40. Yamasaki M, Kishihara K, Mansho K, Ogino Y, Kasai M, Sugano M, Tachibana H, Yamada K. Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes. Biosci Biotechnol Biochem. 2000;64:2159-64.
41. Yamasaki M, Chujo H, Hirao A, Koyanagi N, Okamoto T, Tojo N, Oishi A, Iwata T, Yamauchi-Sato Y, et al. Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid. J Nutr. 2003;133:784-8.
42. Fagarasan S. Evolution, development, mechanism and function of IgA in the gut. Curr Opin Immunol. 2008;20:170-7.
43. Bassaganya-Riera J, Hontecillas-Magarzo R, Bregendahl K, Wannemueh-ler MJ, Zimmerman DR. Effects of dietary conjugated linoleic acid in nursery pigs of dirty and clean environments on growth, empty body composition, and immune competence. J Anim Sci. 2001;79:714-21.