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Volumn 10, Issue 5, 2008, Pages 388-397

New developments in anticoagulation for atrial fibrillation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVITAMIN K; APIXABAN; ATI 5923; AVE 3247; BETRIXABAN; BIOTINYLATED IDRAPARINUX; BLOOD CLOTTING FACTOR 10A INHIBITOR; BLOOD CLOTTING FACTOR 9 INHIBITOR; CLOPIDOGREL; DABIGATRAN; DU 176B; EMD 503982; ENOXAPARIN; IDRAPARINUX; IRBESARTAN; KETOCONAZOLE; KFA 1982; MACROLIDE; N [2 [4 (1 METHYL 4 PIPERIDINYL) 1 PIPERAZINYL] 2 OXO 1 PHENYLETHYL] 1H INDOLE 6 CARBOXAMIDE; PLACEBO; PRT 054021; RIVAROXABAN; SSR 126517E; THROMBIN INHIBITOR; TISSUE FACTOR PATHWAY INHIBITOR; TTP 889; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN; XIMELAGATRAN; YM 150;

EID: 58649086243     PISSN: 10928464     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11936-008-0030-0     Document Type: Review
Times cited : (9)

References (48)
  • 1
    • 33747052359 scopus 로고    scopus 로고
    • Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence
    • Miyasaka Y, Barnes ME, Gersh BJ, et al.: Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation 2006, 114: 119-125.
    • (2006) Circulation , vol.114 , pp. 119-125
    • Miyasaka, Y.1    Barnes, M.E.2    Gersh, B.J.3
  • 2
    • 0020074665 scopus 로고
    • Epidemiologic features of chronic atrial fibrillation: The Framingham Study
    • Kannel WB, Abbott RD, Savage DD, et al.: Epidemiologic features of chronic atrial fibrillation: The Framingham Study. N Engl J Med 1982, 306: 1018-1022.
    • (1982) N Engl J Med , vol.306 , pp. 1018-1022
    • Kannel, W.B.1    Abbott, R.D.2    Savage, D.D.3
  • 3
    • 34347394385 scopus 로고    scopus 로고
    • Meta-analysis: Antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
    • Hart RG, Aearce LA, Aguilar MI: Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 2007, 146: 857-867.
    • (2007) Ann Intern Med , vol.146 , pp. 857-867
    • Hart, R.G.1    Pearce, L.A.2    Aguilar, M.I.3
  • 4
    • 0034627893 scopus 로고    scopus 로고
    • Why do patients with atrial fibrillation not receive warfarin?
    • Bungard TJ, Ghali WA, Teo KK, et al.: Why do patients with atrial fibrillation not receive warfarin? Arch Intern Med 2000, 160: 41-46.
    • (2000) Arch Intern Med , vol.160 , pp. 41-46
    • Bungard, T.J.1    Ghali, W.A.2    Teo, K.K.3
  • 5
    • 33744945247 scopus 로고    scopus 로고
    • ACTIVE Writing Group of the ACTIVE Investigators: Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): A randomised controlled trial
    • Connolly S, Pogue J, Hart R, et al.; ACTIVE Writing Group of the ACTIVE Investigators: Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): A randomised controlled trial. Lancet 2006, 367: 1903-1912.
    • (2006) Lancet , vol.367 , pp. 1903-1912
    • Connolly, S.1    Pogue, J.2    Hart, R.3
  • 6
    • 23944434055 scopus 로고    scopus 로고
    • SPORTIF Executive Steering Committee for the SPORTIF V Investigators: Ximelagatran vs warfarin for stroke prevention in patients with nonvalvular atrial fibrillation: A randomized trial
    • Albers GW, Diener HC, Frison L, et al.; SPORTIF Executive Steering Committee for the SPORTIF V Investigators: Ximelagatran vs warfarin for stroke prevention in patients with nonvalvular atrial fibrillation: A randomized trial. JAMA 2005, 293: 690-698.
    • (2005) JAMA , vol.293 , pp. 690-698
    • Albers, G.W.1    Diener, H.C.2    Frison, L.3
  • 7
    • 0345414673 scopus 로고    scopus 로고
    • Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): Randomised controlled trial
    • Executive Steering Committee of the SPORTIF III Investigators:
    • Executive Steering Committee of the SPORTIF III Investigators: Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): Randomised controlled trial. Lancet 2003, 362: 1691-1698.
    • (2003) Lancet , vol.362 , pp. 1691-1698
  • 8
    • 34547693119 scopus 로고    scopus 로고
    • BAFTA investigators; Midland Research Practices Network (MidReC): Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): A randomised controlled trial
    • Mant J, Hobbs FD, Fletcher K, et al.; BAFTA investigators; Midland Research Practices Network (MidReC): Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet 2007, 370: 493-503.
    • (2007) Lancet , vol.370 , pp. 493-503
    • Mant, J.1    Hobbs, F.D.2    Fletcher, K.3
  • 9
    • 84898691302 scopus 로고    scopus 로고
    • ARYx Therapeutics: Available at Accessed June Pharmacologic and developmental data on ATI-5923
    • ARYx Therapeutics: Pharmacokinetic profile and study evaluation of ATI-5923. Available at www.aryx.com/wt/page/ati5923. Accessed June 2008. Pharmacologic and developmental data on ATI-5923.
    • (2008) Pharmacokinetic Profile and Study Evaluation of ATI-5923
  • 10
    • 33845260086 scopus 로고    scopus 로고
    • Genotypes of the cytochrome p450 isoform, CYP2C9, and the vitamin K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: A prospective study
    • Carlquist JF, Horne BD, Muhlestein JB, et al.: Genotypes of the cytochrome p450 isoform, CYP2C9, and the vitamin K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: A prospective study. J Thromb Thrombolysis 2006, 22: 191-197.
    • (2006) J Thromb Thrombolysis , vol.22 , pp. 191-197
    • Carlquist, J.F.1    Horne, B.D.2    Muhlestein, J.B.3
  • 11
    • 0034573085 scopus 로고    scopus 로고
    • The mechanism of action of thrombin inhibitors
    • Bates SM, Weitz JI: The mechanism of action of thrombin inhibitors. J Invasive Cardiol 2000, 12(Suppl F): 27F-32F.
    • (2000) J Invasive Cardiol , vol.12 , Issue.SUPPL. F
    • Bates, S.M.1    Weitz, J.I.2
  • 12
    • 0031936090 scopus 로고    scopus 로고
    • Thrombin binds to soluble fibrin degradation products where it is protected from inhibition by heparin-antithrombin but susceptible to inactivation by antithrombin-independent inhibitors
    • Weitz JI, Leslie B, Hudoba M: Thrombin binds to soluble fibrin degradation products where it is protected from inhibition by heparin-antithrombin but susceptible to inactivation by antithrombin-independent inhibitors. Circulation 1998, 97: 544-552.
    • (1998) Circulation , vol.97 , pp. 544-552
    • Weitz, J.I.1    Leslie, B.2    Hudoba, M.3
  • 13
    • 28244432534 scopus 로고    scopus 로고
    • Trials and tribulations of non-inferiority: The ximelagatran experience
    • Kaul S, Diamond GA, Weintraub WS: Trials and tribulations of non-inferiority: The ximelagatran experience. J Am Coll Cardiol 2005, 46: 1986-1995.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1986-1995
    • Kaul, S.1    Diamond, G.A.2    Weintraub, W.S.3
  • 14
    • 31544447414 scopus 로고    scopus 로고
    • PETRO-investigators: Safety and efficacy of a new oral direct thrombin inhibitor dabigatran in atrial fibrillation: A dose finding trial with comparison to warfarin
    • Wallentin L, Ezekowitz M, Simmers TA, et al.: PETRO-investigators: Safety and efficacy of a new oral direct thrombin inhibitor dabigatran in atrial fibrillation: A dose finding trial with comparison to warfarin. Eur Heart J 2005, 26(Suppl): 482.
    • (2005) Eur Heart J , vol.26 , Issue.SUPPL. , pp. 482
    • Wallentin, L.1    Ezekowitz, M.2    Simmers, T.A.3
  • 15
    • 0036628436 scopus 로고    scopus 로고
    • BIBR-1048 Boehringer Ingelheim
    • Mungall D: BIBR-1048 Boehringer Ingelheim. Curr Opin Investig Drugs 2002, 3: 905-907.
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 905-907
    • Mungall, D.1
  • 16
    • 35348879239 scopus 로고    scopus 로고
    • Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (PETRO Study)
    • Ezekowitz MD, Reilly PA, Nehmiz G, et al.: Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (PETRO Study). Am J Cardiol 2007, 100: 1419-1426.
    • (2007) Am J Cardiol , vol.100 , pp. 1419-1426
    • Ezekowitz, M.D.1    Reilly, P.A.2    Nehmiz, G.3
  • 17
    • 33750009690 scopus 로고    scopus 로고
    • Safety and efficacy of extended exposure to several doses of a new oral direct thrombin inhibitor dabigatran etexilate in atrial fibrillation [abstract 5]
    • The Petro-ex Investigators
    • The Petro-ex Investigators: Safety and efficacy of extended exposure to several doses of a new oral direct thrombin inhibitor dabigatran etexilate in atrial fibrillation [abstract 5]. Cerebrovasc Dis 2006, 21(Suppl 4): 2.
    • (2006) Cerebrovasc Dis , vol.21 , Issue.SUPPL. 4 , pp. 2
  • 18
    • 32544453399 scopus 로고    scopus 로고
    • New anticoagulants: Anti IIa vs anti Xa'is one better?
    • Bauer KA: New Anticoagulants: anti IIa vs anti Xa'is one better? J Thromb Thrombolysis 2006, 21: 67-72.
    • (2006) J Thromb Thrombolysis , vol.21 , pp. 67-72
    • Bauer, K.A.1
  • 19
    • 22844442726 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 - An oral, direct Factor Xa inhibitor
    • Perzborn E, Strassburger J, Wilmen A, et al.: In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 - an oral, direct Factor Xa inhibitor. J Thromb Haemost 2005, 3: 514-521.
    • (2005) J Thromb Haemost , vol.3 , pp. 514-521
    • Perzborn, E.1    Strassburger, J.2    Wilmen, A.3
  • 20
    • 34250166525 scopus 로고    scopus 로고
    • Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban - An oral, direct factor xa inhibitor - In healthy subjects
    • Mueck W, Becka M, Kubitza D, et al.: Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban - an oral, direct factor xa inhibitor - in healthy subjects. Int J Clin Pharmacol Ther 2007, 45: 335-344.
    • (2007) Int J Clin Pharmacol Ther , vol.45 , pp. 335-344
    • Mueck, W.1    Becka, M.2    Kubitza, D.3
  • 21
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939 - An oral, direct Factor Xa inhibitor - After multiple dosing in healthy male subjects
    • Kubitza D, Becka M, Wensing G, et al.: Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939 - an oral, direct Factor Xa inhibitor - after multiple dosing in healthy male subjects. Eur J Clin Pharmacol 2005, 61: 873-880.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3
  • 22
    • 34547110933 scopus 로고    scopus 로고
    • The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban - An oral, direct Factor Xa inhibitor [abstract]
    • Kubitza D, Becka M, Mueck W, Zuehlsdorf M: The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban - an oral, direct Factor Xa inhibitor [abstract]. Blood 2006, 108: 905.
    • (2006) Blood , vol.108 , pp. 905
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 23
    • 33846448135 scopus 로고    scopus 로고
    • Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects
    • Kubitza D, Becka M, Zuehlsdorf M, Mueck W: Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects. J Clin Pharmacol 2007, 47: 218-226.
    • (2007) J Clin Pharmacol , vol.47 , pp. 218-226
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 24
    • 33645779998 scopus 로고    scopus 로고
    • Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct Factor Xa inhibitor, in healthy subjects
    • Kubitza D, Becka M, Zuehlsdorf M, Mueck W: Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct Factor Xa inhibitor, in healthy subjects. J Clin Pharmacol 2006, 46: 549-558.
    • (2006) J Clin Pharmacol , vol.46 , pp. 549-558
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 25
    • 35848929515 scopus 로고    scopus 로고
    • Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(4-oxopiperidin-1-yl)phenyl) -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa
    • Pinto DJ, Orwat MJ, Koch S, et al.: Discovery of 1-(4-methoxyphenyl)-7 -oxo-6-(4-(4-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J Med Chem 2007, 50:5339-5356.
    • (2007) J Med Chem , vol.50 , pp. 5339-5356
    • Pinto, D.J.1    Orwat, M.J.2    Koch, S.3
  • 26
    • 36348964994 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics and metabolism of apixaban, a potent and selective Factor Xa inhibitor
    • He K, He B, Grace JE, et al.: Preclinical pharmacokinetics and metabolism of apixaban, a potent and selective Factor Xa inhibitor. Blood 2006, 108: 910.
    • (2006) Blood , vol.108 , pp. 910
    • He, K.1    He, B.2    Grace, J.E.3
  • 27
    • 36348978071 scopus 로고    scopus 로고
    • The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement
    • Lassen MR, Davidson BL, Gallus A, et al.: The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. J Thromb Haemost 2007, 5: 2368-2375.
    • (2007) J Thromb Haemost , vol.5 , pp. 2368-2375
    • Lassen, M.R.1    Davidson, B.L.2    Gallus, A.3
  • 28
    • 0141527584 scopus 로고    scopus 로고
    • Short-and long-acting synthetic pentasaccharides
    • Koopman MM, Büller HR: Short-and long-acting synthetic pentasaccharides. J Intern Med 2003, 254: 335-342.
    • (2003) J Intern Med , vol.254 , pp. 335-342
    • Koopman, M.M.1    Büller, H.R.2
  • 30
    • 34147141000 scopus 로고    scopus 로고
    • A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement
    • Agnelli G, Haas S, Ginsberg JS, et al.: A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement. J Thromb Haemost 2007, 5: 746-753.
    • (2007) J Thromb Haemost , vol.5 , pp. 746-753
    • Agnelli, G.1    Haas, S.2    Ginsberg, J.S.3
  • 31
    • 33744787541 scopus 로고    scopus 로고
    • A phase II study of the safety and efficacy of a novel oral FXa inhibitor (LY-517717) for the prevention of venous thromboembolism following TKR or THR [abstract]
    • Agnelli G, Haas SK, Krueger KA, et al.: A phase II study of the safety and efficacy of a novel oral FXa inhibitor (LY-517717) for the prevention of venous thromboembolism following TKR or THR [abstract]. Blood 2005, 106: 278.
    • (2005) Blood , vol.106 , pp. 278
    • Agnelli, G.1    Haas, S.K.2    Krueger, K.A.3
  • 32
    • 58649092974 scopus 로고    scopus 로고
    • Evaluation of the Factor Xa (FXa) inhibitor, PRT054021 (PRT021), against enoxaparin in a randomized trial for the prevention of venous thromboembolic events after total knee replacement (EXPERT) [abstract]
    • Turpie AG, Gent M, Bauer K, et al.: Evaluation of the Factor Xa (FXa) inhibitor, PRT054021 (PRT021), against enoxaparin in a randomized trial for the prevention of venous thromboembolic events after total knee replacement (EXPERT) [abstract]. J Thromb Haemost 2007, 5(Suppl 2): P-T-652.
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 2
    • Turpie, A.G.1    Gent, M.2    Bauer, K.3
  • 33
    • 34447639584 scopus 로고    scopus 로고
    • ONYX study group: A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery
    • Eriksson BI, Turpie AG, Lassen MR, et al.; ONYX study group: A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery. J Thromb Haemost 2007, 5: 1660-1665.
    • (2007) J Thromb Haemost , vol.5 , pp. 1660-1665
    • Eriksson, B.I.1    Turpie, A.G.2    Lassen, M.R.3
  • 34
    • 35048854973 scopus 로고    scopus 로고
    • Anti-thrombotic effects of factor Xa inhibition with DU-176b: Phase-i study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber
    • Zafar MU, Vorchheimer DA, Gaztanaga J, et al.: Anti-thrombotic effects of factor Xa inhibition with DU-176b: Phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber. Thromb Haemost 2007, 98: 883-888.
    • (2007) Thromb Haemost , vol.98 , pp. 883-888
    • Zafar, M.U.1    Vorchheimer, D.A.2    Gaztanaga, J.3
  • 35
    • 0034670013 scopus 로고    scopus 로고
    • Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor-related protein
    • Neels JG, van Den Berg BM, Mertens K, et al.: Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor-related protein. Blood 2000, 96: 3459-3465.
    • (2000) Blood , vol.96 , pp. 3459-3465
    • Neels, J.G.1    van Den Berg, B.M.2    Mertens, K.3
  • 36
    • 0025772165 scopus 로고
    • Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation
    • Lawson JH, Mann KG: Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation. J Biol Chem 1991, 266: 11317-11327.
    • (1991) J Biol Chem , vol.266 , pp. 11317-11327
    • Lawson, J.H.1    Mann, K.G.2
  • 37
    • 0024346843 scopus 로고
    • Platelet receptor occupancy with factor IXa promotes factor X activation
    • Ahmad SS, Rawala-Sheikh R, Walsh PN: Platelet receptor occupancy with factor IXa promotes factor X activation. J Biol Chem 1989, 264: 20012-20016.
    • (1989) J Biol Chem , vol.264 , pp. 20012-20016
    • Ahmad, S.S.1    Rawala-Sheikh, R.2    Walsh, P.N.3
  • 38
    • 0036224113 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans
    • Chow FS, Benincosa LJ, Sheth SB, et al.: Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans. Clin Pharmacol Ther 2002, 71: 235-245.
    • (2002) Clin Pharmacol Ther , vol.71 , pp. 235-245
    • Chow, F.S.1    Benincosa, L.J.2    Sheth, S.B.3
  • 39
    • 33845388596 scopus 로고    scopus 로고
    • First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: A phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity
    • Dyke CK, Steinhubl SR, Kleiman NS, et al.: First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: A phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity. Circulation 2006, 114: 2490-2497.
    • (2006) Circulation , vol.114 , pp. 2490-2497
    • Dyke, C.K.1    Steinhubl, S.R.2    Kleiman, N.S.3
  • 40
    • 34247219508 scopus 로고    scopus 로고
    • TTP889, a novel orally active partial inhibitor of FIXa inhibits clotting in two A/V shunt models without prolonging bleeding times [abstract]
    • Rothlein R, Shen JM, Naser N, et al.: TTP889, a novel orally active partial inhibitor of FIXa inhibits clotting in two A/V shunt models without prolonging bleeding times [abstract]. Blood 2005, 106: 1886.
    • (2005) Blood , vol.106 , pp. 1886
    • Rothlein, R.1    Shen, J.M.2    Naser, N.3
  • 41
    • 39549104685 scopus 로고    scopus 로고
    • For the Fixit Study Group: Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: An exploratory study
    • Eriksson BI, Dahl OE, Lassen MR, et al.; for the Fixit Study Group: Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: An exploratory study. J Thromb Haemost 2008, 6: 457-463.
    • (2008) J Thromb Haemost , vol.6 , pp. 457-463
    • Eriksson, B.I.1    Dahl, O.E.2    Lassen, M.R.3
  • 42
    • 9344230339 scopus 로고    scopus 로고
    • Monoclonal antibody against tissue factor shortens tissue plasminogen activator lysis time and prevents reocclusion in a rabbit model of carotid artery thrombosis
    • Ragni M, Cirillo P, Pascucci I, et al.: Monoclonal antibody against tissue factor shortens tissue plasminogen activator lysis time and prevents reocclusion in a rabbit model of carotid artery thrombosis. Circulation 1996, 93: 1913-1918.
    • (1996) Circulation , vol.93 , pp. 1913-1918
    • Ragni, M.1    Cirillo, P.2    Pascucci, I.3
  • 43
    • 0030824413 scopus 로고    scopus 로고
    • Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function
    • Himber J, Kirchhofer D, Riederer M, et al.: Dissociation of antithrombotic effect and bleeding time prolongation in rabbits by inhibiting tissue factor function. Thromb Haemost 1997, 78: 1142-1149.
    • (1997) Thromb Haemost , vol.78 , pp. 1142-1149
    • Himber, J.1    Kirchhofer, D.2    Riederer, M.3
  • 44
    • 0027954408 scopus 로고
    • A monoclonal antibody against rabbit tissue factor inhibits thrombus formation in stenotic injured rabbit carotid arteries
    • Pawashe A, Golino P, Ambrosio G, et al.: A monoclonal antibody against rabbit tissue factor inhibits thrombus formation in stenotic injured rabbit carotid arteries. Circ Res 1994, 74: 56-63.
    • (1994) Circ Res , vol.74 , pp. 56-63
    • Pawashe, A.1    Golino, P.2    Ambrosio, G.3
  • 45
    • 10744220161 scopus 로고    scopus 로고
    • Administration of a small molecule tissue factor/factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: Effects on thrombus formation and bleeding time
    • Szalony JA, Suleymanov OD, Salyers AK, et al.: Administration of a small molecule tissue factor/factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: Effects on thrombus formation and bleeding time. Thromb Res 2003, 112: 167-174.
    • (2003) Thromb Res , vol.112 , pp. 167-174
    • Szalony, J.A.1    Suleymanov, O.D.2    Salyers, A.K.3
  • 46
    • 0035800075 scopus 로고    scopus 로고
    • Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement
    • Lee A, Agnelli G, Buller H, et al.: Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement. Circulation 2001, 104: 74-78.
    • (2001) Circulation , vol.104 , pp. 74-78
    • Lee, A.1    Agnelli, G.2    Buller, H.3
  • 47
    • 34250775488 scopus 로고    scopus 로고
    • Recombinant nematode anticoagulant protein c2 in patients with non-ST-segment elevation acute coronary syndrome: The ANTHEM-TIMI-32 trial
    • for ANTHEM-TIMI-32 Investigators:
    • Giugliano RP, Wiviott SD, Stone PH, et al.; for ANTHEM-TIMI-32 Investigators: Recombinant nematode anticoagulant protein c2 in patients with non-ST-segment elevation acute coronary syndrome: The ANTHEM-TIMI-32 trial. J Am Coll Cardiol 2007, 49: 2398-2407.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 2398-2407
    • Giugliano, R.P.1    Wiviott, S.D.2    Stone, P.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.