Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice

Clinical Cancer Research

Volumn 6, Issue 12, 2000, Pages 4932-4938

  Perez Soler, Roman ^a   Kemp, Bonnie ^b   Wu, Qing Ping ^a   Mao, Li ^a   Gomez, Jorge ^a   Zeleniuch Jacquotte, Anne ^a   Yee, Herman ^a   Lee, Jin Soo ^b   Jagirdar, Jaishree ^a   Ling, Yi He ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MULTIDRUG RESISTANCE PROTEIN; ONCOPROTEIN; PACLITAXEL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG RESPONSE; DRUG SENSITIVITY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MITOSIS INDEX; MOUSE; NONHUMAN; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ATP-BINDING CASSETTE TRANSPORTERS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; BRONCHIAL NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; GENES, P53; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; MITOSIS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; NEOPLASM TRANSPLANTATION; PACLITAXEL; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0034488466     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
2. Molecular abnormalities in lung cancer
3. In vitro determination of drag response: A discussion of clinical applications
4. Evidence of a direct relationship between the increase in the in vitro passage number of human non-small-cell-lung cancer primocultures and their chemosensitivity
5. Heterotransplantation of human breast carcinomas in nude mice. Correlation between successful heterotransplants, poor prognosis and amplification of the HER-2/neu oncogene
6. Transplantation of human tumors in nude mice
7. Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis
8. Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with Taxol
9. Phase II study of 3-hour infusion of paclitaxel in previously untreated non-small cell lung cancer
10. Phase II trial of a 3-hour infusion of paclitaxel in previously untreated patients with advanced non-small-cell lung cancer
11. Phase II study of Taxol in patients with untreated advanced non-small-cell lung cancer
12. Phase II study of Taxol, merbarone, and piroxantrone in stage IV non-small-cell lung cancer: The Eastern Cooperative Oncology Group Results
13. Clinical prognostic relevance of growth of human adenocarcinomas of the lung in nude mice
14. Growth of human bronchial carcinomas in nude mice
15. Correlation between successful heterotransplantation of lung tumors in nude mice, poor prognosis of patients and expression of Fos, Jun, ErbB1, and Ras
16. Amplification and expression of a cellular oncogene (c-myc) in human gastric adenocarcinoma cells
17. Engraftment of human tumor-infiltrating lymphocytes and the production of anti-tumor antibodies in SCID mice
18. Xenotransplantability of human squamous cell lung cancer in nude mice is not affected by angiogenic factors
19. Prognostic significance of B-lineage leukemic cell growth in SCID mice
20. Human renal cell carcinoma xenografts in SCID mice: Tumorigenicity correlates with a poor clinical prognosis
21. Tumorigenicity of cerebellar primitive neuro-ectodermal tumors in athymic mice correlates with poor prognosis in children
22. Growth of xenografted squamous cell carcinoma of the head and neck- possible correlation with patient survival
23. Metastatic potential of human colorectal carcinomas implanted into nude mice: Prediction of clinical outcome in patients operated upon for cure
24. Prognostic significance of growth characteristics of xenotransplanted ovarian carcinomas into nude mice
25. Transplantation of human osteosarcoma into nude mouse-correlation between experiment results and prognosis of patients
26. Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to Taxol
27. Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase
28. Bcl-2-mediated drug resistance: Inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription
29. Bc1-2 protein in non-small-cell lung carcinoma
30. p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel
31. Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents
32. Paclitaxel sensitivity correlates with p53 status and DNA fragmentation, but not G2/M accumulation
33. Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis
34. Relationship of mitotic arrest and apoptosis to antitumor effect of paelitaxel
35. Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific β-tubulin isotypes
36. Paclitaxel resistance in non-small-cell lung cancer associated with βtubulin gene mutations