Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats

Brain Research

Volumn 718, Issue 1-2, 1996, Pages 129-137

  Thomas, David A ^a,b   Navarrete, Isabel M ^b   Graham, Brent A ^b   McGowan, Malcolm K ^b   Hammond, Donna L ^b  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Antinociception; CGP 35348; GABA; GABA(B) receptor; Nucleus raphe magnus; Nucleus reticularis gigantocellularis pars

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BACLOFEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; INTRATHECAL DRUG ADMINISTRATION; MALE; MEDULLA OBLONGATA; NONHUMAN; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; SPINAL CORD; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029950247     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00100-X     Document Type: Article

References (43)

1. Advokat, C. and Burton, P., Antinociceptive effect of systemic and intrathecal morphine in spinally-transected rats, Eur. J. Pharmacol., 139 (1987) 335-343.
2. Advokat, C. and Gulati, A., Spinal transection reduces both spinal antinociception and CNS concentration of systemically administered morphine in rats, Brain Res., 555 (1991) 251-258.
3. B receptor antagonists, Am. J. Physiol., 266 (1994) H1722-H1728.
4. Bertman, L.J. and Advokat, C., Comparison of the antinociceptive and antispastic action of (-)baclofen after systemic and intrathecal administration in intact, acute and chronic spinal rats, Brain Res., 684 (1995) 8-18.
5. B Receptors in Mammalian Function, Wiley and Sons, Chicester, 1990, pp. 47.
6. B receptor pharmacology, Ann. Rev. Pharmacol. Toxicol., 33 (1993) 109-147.
7. Bowery, N.G., Hill, D.R. and Hudson, A.L., Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes, Br. J. Pharmacol., 78 (1983) 191-206.
8. B receptor site distribution in the rat central nervous system, Neuroscience, 20 (1987) 365-383.
9. Cutting, D.A. and Jordan, C.C., Alternative approaches to analgesia: baclofen as a model compound, Br. J. Pharmacol., 54 (1975) 171-179.
10. D'Amour, F.E. and Smith, D.L., A method for determining loss of pain sensation, J. Pharmacol. Exp. Ther., 72 (1941) 74-79.
11. Dirig, D.M. and Yaksh, T.L., Intrathecal baclofen and muscimol, but not midazolam are antinociceptive in the rat-formalin model, J. Pharmacol. Exp. Ther., 275 (1995) 219-227.
12. Drawer, E.J. and Hammond, D.L., GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat, Brain Res., 450 (1988) 316-324.
13. Giuliani, S., Evangelista, S., Borsini, F. and Meli, A., Intracerebroventricular phaclofen antagonizes baclofen antinociceptive activity in hot plate test with mice, Eur. J. Pharmacol., 154 (1988) 225-226.
14. Hammond, D.L., Intrathecal administration: methodological considerations, Prog. Brain Res., 77 (1988) 313-320.
15. Hammond, D.L. and Drower, E.J., Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold, Eur. J. Pharmacol., 103 (1984) 121-125.
16. Hammond, D.L. and Washington, J.D., Antagonism of L-Baclofen-induced antinociception by CGP 35,348 in the spinal cord of the rat, Eur. J. Pharmacol., 234 (1993) 255-262.
17. B) receptor antagonist CGP 35348 induces hypersensitivity to mechanical stimuli in the rat, Neurosci. Lett., 182 (1994) 299-302.
18. B) receptor antagonist CGP 35348 induces hypersensitivity to mechanical stimuli in the rat, Neurosci. Lett., 182 (1994) 299-302.
19. Heinricher, M.M. and Kaplan, H.J., GABA-mediated inhibition in rostral ventromedial medulla: role in nociceptive modulation in the lightly anesthetized rat, Pain, 47 (1991) 105-113.
20. Hill, R.C., Maurer, R., Buescher, H.-H. and Roemer, D., Analgesic properties of the GABA-mimetic THIP, Eur. J. Pharmacol., 69 (1981) 221-224.
21. B receptors and substance P in the mouse spinal cord, J. Pharmacol. Exp. Ther., 248 (1989) 1026-1033.
22. Hynes, M.D., Leander, J.D., Frederickson, R.C.A., Ho, P.P.K., Johnson, D.W. and Archer, R.A., Evaluation of THIP in standard tests of analgesic activity: occurrence of antinociception and hyperalgesia, Drug Devel. Res., 4 (1984) 405-419.
23. Irwin, S., Houde, R.W., Bennet, D.R., Hendershot, L.C. and Seevers, M.H., The effects of morphine, methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation, J. Pharmacol. Exp. Ther., 101 (1951) 132-143.
24. Jones, B.E., Reticular formation: cytoarchitecture, transmitters, and projections. In G. Paxinos (Ed.), The Rat Nervous System, Academic Press, San Diego, 1995, pp. 155-171.
25. Keppel, G., Design and Analysis. A Researcher's Handbook, Prentice-Hall, Englewood Cliffs, 1973, 565 pp.
26. Kerr, D.I.B. and Ong, J., GABA agonists and antagonists, Med. Res. Rev., 12 (1992) 593-636.
27. Levy, R.A. and Proudfit, H.K., The analgesic action of baclofen [β-(4-chlorophenyl)-γ-aminobutyric acid], J. Pharmacol. Exp. Ther., 202 (1977) 437-445.
28. Levy, R.A. and Proudfit, H.K., Analgesia produced by microinjection of baclofen and morphine at brain stem sites, Eur. J. Pharmacol., 57 (1979) 43-55.
29. Liebman, J.M. and Pastor, G., Antinociceptive effects of baclofen and muscimol upon intraventricular administration, Eur. J. Pharmacol., 61 (1980) 225-230.
30. B antagonist, prevents antinociception and muscle-relaxant effect induced by baclofen, Br. J. Pharmacol., 103 (1991) 1303-1308.
31. B receptors, Eur. J. Pharmacol., 187 (1990) 27-38.
32. Proudfit, H.K. and Levy, R.A., Delimitation of neuronal substrates necessary for the analgesic action of baclofen and morphine, Eur. J. Pharmacol., 47 (1978) 159-166.
33. Rivlin, A.S. and Tator, C.H., Objective clinical assessment of motor function after experimental spinal cord injury in the rat, Neurosurgery, 47 (1977) 577-581.
34. Sawynok, J. and Dickson, C., D-Baclofen is an antagonist at baclofen receptors mediating antinociception in the spinal cord, Pharmacology, 31 (1985) 248-259.
35. B receptors in the nucleus tractus solitarius modulates the baroreceptor reflex, Brain Res., 592 (1994) 37-43.
36. Thomas, D.A., McGowan, M.K. and Hammond, D.L., Microinjection of baclofen in the ventromedial medulla of the rat produces antinociception or hyperalgesia, J. Pharmacol. Exp. Ther., 275 (1995) 274-284.
37. Waldvogel, H.J., Faull, R.L.M., Jansen, K.L.R., Dragunow, M., Richards, J.G., Mohler, H. and Street, P., GABA, GABA receptors and benzodiazepine receptors in the human spinal cord: an autoradiographic and immunohistochemical study at the light and electron microscopic levels, Neuroscience, 39 (1990) 361-385.
38. Wilson, P.R. and Yaksh, T.L., Baclofen is antinociceptive in the spinal intrathecal space of animals, Eur. J. Pharmacol., 51 (1978) 323-330.
39. Witczuk, B., Khaunina, R.A. and Kupryszewski, G., 3-(p-chlorophenyl)-4-aminobutyric acid - resolution into enantiomers and pharmacological activity, Pol. J. Pharmacol. Pharm., 32 (1980) 187-196.
40. Woolfe, G. and MacDonald, A.D., The evaluation of the analgesic action of pethidine hydrochloride (Demerol), J. Pharmacol. Exp. Ther., 80 (1944) 300-307.
41. Yaksh, T.L. and Reddy, S.V.R., Studies in the primate on the analgetic effects associated with intrathecal actions of opiate, alpha-adrenergic agonists and baclofen, Anesthesiology, 54 (1981) 451-467.
42. Yaksh, T.L. and Rudy, T.A., Chronic catheterization of the spinal subarachnoid space, Physiol. Behav., 17 (1976) 1031-1036.
43. Zorn, S.H. and Enna, S.J., The effect of mouse spinal cord transection on the antinociceptive response to the γ-aminobutyric acid agonists THIP (4,5,6,7-tetrahydroisaxazolo-[5,4-c]pyridin-3-ol) and baclofen, Brain Res., 338 (1985) 380-383.