Immuno-suppressive effect of blocking the CD28 signaling pathway in T-cells by an active component of Echinacea found by a novel pharmaceutical screening method

Journal of Medicinal Chemistry

Volumn 49, Issue 6, 2006, Pages 1845-1854

  Dong, Guo Chung ^a   Chuang, Ping Hsien ^a   Forrest, Michael D ^a,b   Lin, Yi Chen ^a   Chen, Hueih Min ^a  

^a AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CYNARINE; ECHINACEA PURPUREA EXTRACT; HERBACEOUS AGENT; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; TSUKUBAENOLIDE;

ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOWN REGULATION; DRUG RECEPTOR BINDING; DRUG SCREENING; ECHINACEA PURPUREA; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NONHUMAN; SCREENING TEST; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD28; ANTIGENS, CD80; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNAMATES; ECHINACEA; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; JURKAT CELLS; MICE; PLANT EXTRACTS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; T-LYMPHOCYTES;

EID: 33645381049     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0509039     Document Type: Article

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