PH control strategy in a shaken minibioreactor for polysaccharide production by medicinal mushroom Phellinus linteus and its anti-hyperlipemia activity

Bioprocess and Biosystems Engineering

Volumn 32, Issue 2, 2009, Pages 277-281

  Zou, Xiang ^a   Guo, Xia ^a   Sun, Min ^a  

^a SOUTHWEST UNIVERSITY   (China)

Author keywords

Anti hyperlipemia activity; EPS; IPS; Phellinus linteus; Shaken bioreactor

Indexed keywords

ANTI-HYPERLIPEMIA ACTIVITY; EPS; IPS; PHELLINUS LINTEUS; SHAKEN BIOREACTOR;

BIOCHEMICAL ENGINEERING; BIOPOLYMERS; BIOREACTORS; BODY FLUIDS; CELL GROWTH; CHOLESTEROL; ENZYME ACTIVITY; GROWTH KINETICS; INDUSTRIAL CHEMICALS; PH; PH EFFECTS; PREDICTIVE CONTROL SYSTEMS; SWITCHING SYSTEMS; UNINTERRUPTIBLE POWER SYSTEMS;

POLYSACCHARIDES;

ANTILIPEMIC AGENT; CHINESE DRUG; CHOLESTEROL; EXOPOLYSACCHARIDE; HIGH DENSITY LIPOPROTEIN; JIANGZHILING; LOW DENSITY LIPOPROTEIN; POLYSACCHARIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOREACTOR; CARBOHYDRATE ANALYSIS; CARBOHYDRATE SYNTHESIS; CELL DENSITY; CELL GROWTH; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG MEGADOSE; DRUG POTENCY; FEMALE; FUNGUS CULTURE; HYPERLIPIDEMIA; LIPOPROTEIN BLOOD LEVEL; LOW DRUG DOSE; MALE; MOUSE; MUSHROOM; MYCELIUM; NONHUMAN; PH; PHELINNUS LINTEUS; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

AGARICALES; BIOREACTORS; FERMENTATION; HYDROGEN-ION CONCENTRATION; HYPERLIPIDEMIAS; POLYSACCHARIDES;

BASIDIOMYCOTA; FUNGI; INONOTUS LINTEUS; MUS;

EID: 58549101878     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-008-0241-5     Document Type: Article

References (19)

1. G Li DH Kim TD Kim BJ Park HD Park JI Park MK Na HC Kim ND Hong K Lim 2004 Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells Cancer Lett 216 175 181
2. GY Kim JY Lee JO Lee CH Ryu BT Choi YK Jeong KW Lee SC Jeong YH Choi 2006 Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus Biosci Biotech Bioch 70 1218 1226
3. D Sliva J Kawasaki G Stanley K Harvey V Slivova 2006 Phellinus linteus inhibits growth and invasive behavior of breast cancer cells through the suppression of Akt signaling FASEB J 20 559 560
4. BC Kim WK Jeon HY Hong KB Jeon JH Hahn YM Kim S Numazawa T Yosida EH Park CJ Lim 2007 The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKC[delta]/Nrf2/ARE signaling to up-regulation of heme oxygenase-1 J Ethnopharmacol 113 240 247
5. IH Park SK Chung KB Lee YC Yoo SK Kim GS Kim KS Song 2004 An antioxidant hispidin from the mycelial cultures of Phellinus linteus Arch Pharm Res 27 615 618
6. X Zou M Sun X Guo 2006 Quantitative response of cell growth and polysaccharide biosynthesis by the medicinal mushroom Phellinus linteus to NaCl in the medium World J Microb Biot 22 1129 1133
7. JH Xiao DX Chen WH Wan XJ Hu Y Qi ZQ Liang 2006 Enhanced simultaneous production of mycelia and intracellular polysaccharide in submerged cultivation of Cordyceps jiangxiensis using desirability functions Process Biochem 41 1887 1893
8. LF Fan AT Soccol A Pandey CR Soccol 2007 Effect of nutritional and environmental conditions on the production of exo-polysaccharide of Agaricus brasiliensis by submerged fermentation and its antitumor activity Lwt-Food Sci Technol 40 30 35
9. ES Lin SC Sung 2006 Cultivating conditions influence exopolysaccharide production by the edible basidiomycete Antrodia cinnamomea in submerged culture Int J Food Microbiol 108 182 187
10. HM Kim MK Park JW Yun 2006 Culture pH affects exopolysaccharide production in submerged mycelial culture of Ganoderma lucidum Appl Biochem Biotech 134 249 262
11. KM Lee SY Lee HY Lee 1999 Biostage control of pH for improving exopolysaccharide production from mycelia of Ganoderma lucidum in an air-lift fermentor J Biosci Bioeng 6 646 650
12. QH Fang JJ Zhong 2002 Effect of initial pH on production of ganoderic acid and polysaccharide by submerged fermentation of Ganoderma lucidum Process Biochem 37 769 774
13. CP Pokhrel S Ohga 2007 Submerged culture conditions for mycelial yield and polysaccharides production by Lyophyllum decastes Food Chem 105 641 646
14. SW Kim HJ Hwang CP Xu JM Sung JW Choi JW Yun 2003 Optimization of submerged culture process for the production of mycelial biomass and exo-polysaccharides by Cordyceps militaris C738 J Appl Microbiol 94 120 126
15. JI Betts F Baganz 2006 Miniature bioreactors: current practices and future opportunities Microb Cell Fact 5 21 35
16. P Fernandes JMS Cabral 2006 Microlitre/millilitre shaken bioreactors in fermentative and biotransformation processes a review Biocatal Biotransfor 24 237 252
17. GL Miller 1959 Use of dinitrosalicylic acid reagent for determ ination of reducing sugar Anal Chem 31 426 428
18. F Dmgkahjkrpas 1956 Colorimetric method for determination of sugars and related substances Anal Chem 28 350 356
19. JH Xiao JW Liu ZL Liu WH Wan N Fang Y Xiao Y Qi ZQ Liang 2004 Optimization of submerged culture requirments for production of mycelial growth and exopolysaccharide by Cordyceps jiangxiensis JXP 0109 J Appl Microbiol 96 1105 1116