HY253, a novel compound isolated from Aralia continentalis, induces apoptosis via cytochrome c-mediated intrinsic pathway in HeLa cells

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 797-799

  Oh, Ha Lim ^a   Lim, Haeyoung ^a   Park, Younghee ^b   Lim, Yoongho ^b   Koh, Hyun Chul ^a   Cho, Youl Hee ^a   Lee, Chul Hoon ^a  

^a Hanyang University   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

Apoptotic induction; Aralia continentalis; Cytochrome c; HeLa cells

Indexed keywords

7,8A DIVINYL 2,4A,4B,5,6,7,8,8A,9,9A DECAHYDRO 1H FLUORENE 2,4A,4B,9A TETRAOL; ARALIA CONTINENTALIS EXTRACT; BETA ACTIN; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; HY 253; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT EXTRACT; PROCASPASE 3; PROCASPASE 8; PROCASPASE 9; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVATION; ENZYME RELEASE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; NICK END LABELING; PLANT ROOT; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARALIA; CYTOCHROMES C; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; FLUORENES; HELA CELLS; HUMANS; IN SITU NICK-END LABELING; MAGNETIC RESONANCE SPECTROSCOPY; MITOCHONDRIA; MODELS, CHEMICAL; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2;

ARALIA CONTINENTALIS;

EID: 58549091839     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.009     Document Type: Article

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