The co-chaperone BAG3 regulates Herpes Simplex Virus replication

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 52, 2008, Pages 20912-20917

  Kyratsous, Christos A ^a   Silverstein, Saul J ^a  

^a Columbia University ^*  (United States)

Author keywords

Hsc70; HSV; ICP0; VZV

Indexed keywords

CHAPERONE; PROTEIN BAG3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; GENE EXPRESSION; HERPES SIMPLEX VIRUS; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DEPLETION; PROTEIN EXPRESSION; VIRUS GENE; VIRUS REPLICATION; VIRUS STRAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE; GENE EXPRESSION REGULATION, VIRAL; HUMANS; MOLECULAR CHAPERONES; SIMPLEXVIRUS; VIRUS REPLICATION;

HERPESVIRIDAE; HUMAN HERPESVIRUS 3; SIMPLEXVIRUS;

EID: 58549086337     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0810656105     Document Type: Article

References (54)

1. Weir JP (2001) Regulation of herpes simplex virus gene expression. Gene 271:117-130.
2. Pereira L, Wolff MH, Fenwick M, Roizman B (1977) Regulation of herpesvirus macromolecular synthesis. V. Properties of alpha polypeptides made in HSV-1 and HSV-2 infected cells. Virology 77:733-749.
3. Everett RD (1989) Construction and characterization of herpes simplex virus type 1 mutants with defined lesions in immediate early gene 1. J Gen Virol 70:1185-1202.
4. Stow ND, Stow EC (1986) Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide Vmw110. J Gen Virol 67:2571-2585.
5. Everett RD (1985) Activation of cellular promoters during herpes virus infection of biochemically transformed cells. EMBO J 4:1973-1980.
6. Gelman IH, Silverstein S (1985) Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene. Proc Natl Acad Sci USA 82:5265-5269.
7. Quinlan MP, Knipe DM (1985) Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions. Mol Cell Biol 5:957-963.
8. Everett RD (2000) ICP0, a regulator of herpes simplex virus during lytic and latent infection. Bioessays 22:761-770.
9. Gu H, Roizman B (2007) Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex. Proc Natl Acad Sci USA 104:17134-17139.
10. Chelbi-Alix MK, de The H (1999) Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins. Oncogene 18:935-941.
11. Everett RD, Earnshaw WC, Findlay J, Lomonte P (1999) Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110. EMBO J 18:1526-1538.
12. Everett RD, Maul GG (1994) HSV-1 IE protein Vmw110 causes redistribution of PML. EMBO J 13:5062-5069.
13. Lomonte P, Sullivan KF, Everett RD (2001) Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0. J Biol Chem 276:5829-5835.
14. Gu H, Roizman B (2003) The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin- conjugating enzyme UbcH5a. Proc Natl Acad Sci USA 100:8963-8968.
15. Everett RD, Sourvinos G, Leiper C, Clements JB, Orr A (2004) Formation of nuclear foci of the herpes simplex virus type 1 regulatory protein ICP4 at early times of infection: Localization, dynamics, recruitment of ICP27, and evidence for the de novo induction of ND10-like complexes. J Virol 78:1903-1917.
16. Everett RD, Parada C, Gripon P, Sirma H, Orr A (2008) Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100. J Virol 82:2661-2672.
17. Everett RD, et al. (2006) PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0. J Virol 80:7995-8005.
18. Maul GG (1998) Nuclear domain 10, the site of DNA virus transcription and replication. BioEssays 20:660-667.
19. Tavalai N, Papior P, Rechter S, Leis M, Stamminger T (2006) Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections. J Virol 80:8006-8018.
20. Lium EK, Silverstein S (1997) Mutational analysis of the herpes simplex virus type 1 ICP0 C3HC4 zinc ring finger reveals a requirement for ICP0 in the expression of the essential alpha27 gene. J Virol 71:8602-8614.
21. Livingston CM, DeLuca NA, Wilkinson DE, Weller SK (2008) Oligomerization of ICP4 and rearrangement of heat shock proteins may be important for herpes simplex virus type 1 prereplicative site formation. J Virol 82:6324-6336.
22. Burch AD, Weller SK (2004) Nuclear sequestration of cellular chaperone and proteasomal machinery during herpes simplex virus type 1 infection. J Virol 78:7175-7185.
23. Li L, Johnson LA, Dai-Ju JQ, Sandri-Goldin RM (2008) Hsc70 Focus Formation at the Periphery of HSV-1 Transcription Sites Requires ICP27. PLoS ONE 3:e1491.
24. Kyratsous CA, Silverstein SJ (2007) BAG3, a host cochaperone, facilitates varicella-zoster virus replication. J Virol 81:7491-7503.
25. Takayama S, Xie Z, Reed JC (1999) An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem 274:781-786.
26. Lium EK, Panagiotidis CA, Wen X, Silverstein SJ (1998) The NH2 terminus of the herpes simplex virus type 1 regulatory protein ICP0 contains a promoter-specific transcription activation domain. J Virol 72:7785-7795.
27. Kawaguchi Y, Van Sant C, Roizman B (1997) Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3. J Virol 71:7328-7336.
28. Lopez P, Van Sant C, Roizman B (2001) Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1. J Virol 75:3832-3840.
29. Moriuchi H, Moriuchi M, Smith HA, Straus SE, Cohen JI (1992) Varicella-zoster virus open reading frame 61 protein is functionally homologous to herpes simplex virus type 1 ICP0. J Virol 66:7303-7308.
30. Poon AP, Silverstein SJ, Roizman B (2002) An early regulatory function required in a cell type-dependent manner is expressed by the genomic but not the cDNA copy of the herpes simplex virus 1 gene encoding infected cell protein 0. J Virol 76:9744-9755.
31. Preston CM, Frame MC, Campbell ME (1988) A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence. Cell 52:425-434.
32. Kristie TM, LeBowitz JH, Sharp PA (1989) The octamer-binding proteins form multiprotein-DNA complexes with the HSV alpha TIF regulatory protein. EMBO J 8:4229-4238.
33. Hancock MH, Corcoran JA, Smiley JR (2006) Herpes simplex virus regulatory proteins VP16 and ICP0 counteract an innate intranuclear barrier to viral gene expression. Virology 352:237-252.
34. Gu H, Liang Y, Mandel G, Roizman B (2005) Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. Proc Natl Acad Sci USA 102:7571-7576.
35. Kawaguchi Y, Matsumura T, Roizman B, Hirai K (1999) Cellular elongation factor 1delta is modified in cells infected with representative alpha-, beta-, or gammaherpesviruses. J Virol 73:4456-4460.
36. Doong H, Vrailas A, Kohn EC (2002) What's in the 'BAG'?-A functional domain analysis of the BAG-family proteins. Cancer Lett 188:25-32.
37. Doong H, et al. (2003) CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediatedprotein degradation: Accumulationof poly-ubiquitinated Hsp90 client proteins. J Biol Chem 278:28490-28500.
38. Liu JS, et al. (1998) Human Hsp70 and Hsp40 chaperone proteins facilitate human papillomavirus-11E1 protein binding to the origin and stimulate cell-free DNA replication. J Biol Chem 273:30704-30712.
39. Jeon YK, et al. (2007) The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T cell lymphoma by Akt downregulation. J Pathol 213:170-179.
40. Stahl M, Retzlaff M, Nassal M, Beck J (2007) Chaperone activation of the hepadnaviral reverse transcriptase for template RNA binding is established by the Hsp70 and stimulated by the Hsp90 system. Nucleic Acids Res 35:6124-6136.
41. Basha W, et al. (2005) Geldanamycin, a potent and specific inhibitor of Hsp90, inhibitsgene expression and replication of human cytomegalovirus. Antivir Chem Chemother 16:135-146.
42. Connor JH, McKenzie MO, Parks GD, Lyles DS (2007) Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses. Virology 362:109-119.
43. Okamoto T, et al. (2006) Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. EMBO J 25:5015-5025.
44. Samaniego LA, Wu N, DeLuca NA (1997) The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27. J Virol 71:4614-4625.
45. Panagiotidis CA, Lium EK, Silverstein SJ (1997) Physical and functional interactions between herpes simplex virus immediate-early proteins ICP4 and ICP27. J Virol 71:1547-1557.
46. Chen J, Silverstein S (1992) Herpes simplex viruses with mutations in the gene encoding ICP0 are defective in gene expression. J Virol 66:2916-2927.
47. Grose C, Brunel PA (1978) Varicella-zoster virus: Isolation and propagation in human melanoma cells at 36 and 32 degrees C. Infect Immun 19:199-203.
48. Koyama K, Osame J (2000) USPTO 6039958.
49. Provost PJ, Krah DL, Friedman PA (1997) USPTO 5607852.
50. Stolarov J, et al. (2001) Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proc Natl Acad Sci USA 98:13043-13048.
51. Brummelkamp TR, Bernards R, Agami R (2002) Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2:243-247.
52. Gelman IH, Silverstein S (1987) Herpes simplex virus immediate-early promoters are responsive to virus and cell trans-acting factors. J Virol 61:2286-2296.
53. Walters MS, Kyratsous CA, Wan S, Silverstein S (2008) Nuclear import of the varicella-zoster virus latency-associated protein ORF63 in primary neurons requires expression of the lytic protein ORF61 and occurs in a proteasome-dependent manner. J Virol 82:8673-8686.
54. Lium EK, Panagiotidis CA, Wen X, Silverstein S (1996) Repression of the alpha0 gene by ICP4 during a productive herpes simplex virus infection. J Virol 70:3488-3496.