Insulin-like growth factor-1 and transforming growth factor-β1 accelerates osteotomy healing using polylactide-coated implants as a delivery system: A biomechanical and histological study in minipigs

Bone

Volumn 30, Issue 1, 2002, Pages 144-151

  Raschke, M ^a   Wildemann, B ^a   Inden, P ^a   Bail, H ^a   Flyvbjerg, A ^b   Hoffmann, J ^a   Haas, N P ^a   Schmidmaier, G ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

(PDLLA); Biodegradable coating; Insulin like growth factor 1 (IGF 1); Minipig; Osteotomy healing; Poly(D,L lactide); Transforming growth factor 1 (TGF 1)

Indexed keywords

POLYLACTIDE; SOMATOMEDIN; TITANIUM; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BODY WEIGHT; BONE DENSITY; CARTILAGE CELL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FRACTURE; FRACTURE HEALING; NONHUMAN; TEMPERATURE; TIBIA OSTEOTOMY;

ANIMALS; BIOMECHANICS; BONY CALLUS; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; FEMALE; FRACTURE FIXATION, INTRAMEDULLARY; FRACTURE HEALING; HUMANS; INSULIN-LIKE GROWTH FACTOR I; OSTEOTOMY; POLYESTERS; RECOMBINANT PROTEINS; SWINE; SWINE, MINIATURE; TIBIAL FRACTURES; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; WOUND HEALING;

EID: 0036138695     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(01)00640-8     Document Type: Article

References (32)

1. Bone morphogenetic protein-2 increases the rate of callus formation after fracture of the rabbit tibia
2. TGF-beta1 induces bone closure of skull defects-Temporal dynamics of bone formation in defects exposed to rhTGF-beta1
3. Potential role of bone morphogenetic proteins in fracture healing
4. Radiographic analysis of regenerated bone around endosseous implants in the canine using recombinant human bone morphogenetic protein-2
5. Inhibitory effect of a growth hormone receptor antagonist (G120K-PEG) on renal enlargement, glomerular hypertrophy, and urinary albumin excretion in experimental diabetes in mice
6. Local effects of transforming growth factor-betal on rat calvaria; changes depending on the dose and the injection site
7. Stimulation of bone healing by transforming growth factor-beta 1 released from polymeric or ceramic implants
8. Insulin like growth factor I has independent effects on bone matrix formation and cell replication
9. Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur
10. Interactions of growth factors present in bone matrix with bone cells; Effects on DNA synthesis and alkaline phosphatase
11. Biodegradable poly(lactic acid) polymers
12. Polylactic acid for surgical implants
13. Poly/(lactic acid) and poly(glycolic acid)
14. Growth factor stimulation of bone healing. Effects on osteoblasts, osteomies, and implants fixation
15. Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds
16. Regulation by IGF-I and TGF-beta1 of Swarm-rat chondrosarcoma chondrocytes
17. Bone growth factors
18. Stimulation of endosteal bone formation by systemic injections of recombinant basic fibroblast growth factor in rats
19. Bone histomorphometry; Standardization of nomenclature, symbols and units
20. SR-PLLA and SR-PGA miniscrews; Biodegradation and tissue reactions in the calvarium and dura mater
21. Stimulation of bone matrix apposition in vitro by local growth factors; A comparison between insulin-like growth factor I, platelet-derived growth factor and transforming growth factor beta
22. Recombinant growth hormone accelerates bone regenerate consolidation in distraction osteogenesis
23. Local application of growth factors (insulin-like growth factor-1 and transforming growth factor-β1) from a biodegradable poly(D,L-lactide) coating of osteosynthetic implants accelerates fracture healing in rats
24. Insulin like growth factor-I (IGF-I) and transforming growth factor-β1 (TGF-β1) have synergistic effects on fracture healing in rats
25. Biodegradable poly(D,L-lactide) coating of implants for continuous release of growth factors
26. Telopeptide-depleted bovine skin collagen as a carrier for bone morphogenetic protein
27. Pathology of recombinant human transforming growth factor-beta 1 in rats and rabbits
28. Effect of transforming growth factor-beta on the insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes
29. Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model
30. Treatment with recombinant human insulin-like growth factor I of children with growth hormone receptor deficiency (Laron syndrome)
31. Acute metabolic effects and half-lives of intravenously administered insulinlike growth factors I and II in normal and hypophysectomized rats
32. Pharmacokinetics and tissue distribution of recombinant human transforming growth factor beta 1 after topical and intravenous administration in male rats