New polymers for drug delivery systems in orthopaedics: In vivo biocompatibility evaluation

Biomedicine and Pharmacotherapy

Volumn 58, Issue 8 SPEC. ISS., 2004, Pages 411-417

  Giavaresi, G ^a,c   Tschon, M ^a   Borsari, V ^a   Daly, J H ^b   Liggat, J J ^b   Fini, M ^a,c   Bonazzi, V ^a,c   Nicolini, A ^d   Carpi, A ^d   Morra, M ^e   Cassinelli, C ^e   Giardino, R ^a,c  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c Dept of Sci R and D   (Italy)

^d UNIVERSITY OF PISA   (Italy)

^e Nobil Bio Ricerche Srl   (Italy)

Author keywords

Animal model; Drug delivery systems; Implants; Polyesters; Polymers; Polyphosphazenes

Indexed keywords

BIOPOL; COPOLYMER; D 400G; D 600G; IMIDAZOLE; POLY(CYCLOHEXYL SEBACATE); POLY(LEVO LACTIDE B 1,5 DIOXEPAN 2 ONE B LEVO LACTIDE); POLY(ORGANO)PHOSPHAZENE; POLYCAPROLACTONE; POLYESTER; POLYMER; TONE P 787; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG SCREENING; FEMALE; IMPLANTATION; INFLAMMATION; NONHUMAN; ORTHOPEDICS; PRIORITY JOURNAL; RAT; SUBCUTANEOUS TISSUE; TISSUE REACTION;

EID: 5344265073     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2004.08.001     Document Type: Article

References (36)

1. N. Aldini, P. Caliceti, S. Lora, M. Fini, G. Giavaresi, and M. Rocca Calcitonin release system in the treatment of experimental osteoporosis. Histomorphometric evaluation J. Orthop. Res. 19 2001 955 961
2. A. Andrianov, and L. Payne Protein release from polyphosphazene matrices Adv. Drug Deliv. Rev. 31 1998 185 196
3. E. Baran, N. Ozer, and V. Hasirci Poly(hydroxybutyrate-co- hydroxyvalerate) nanocapsules as enzyme carriers for cancer therapy: an in vitro study J. Microencapsul. 19 2002 363 376
4. D. Braun, and P. Hempler Grafting of polyesters by free-radical chain transfer Die Angewandte Makromol Chemie 210 1993 173 196
5. R. Chambers, J.H. Daly, D. Hayward, and J.J. Liggat The effect of processing on the properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymers J. Mate Sci. 36 2001 3785 3792
6. J. Chen, and S. Davis The release of diazepam from poly(hydroxybutyrate- hydroxyvalerate) microspheres J. Microencapsul. 19 2002 191 201
7. R. Giardino, M. Fini, N. Aldini, G. Giavaresi, M. Rocca, and L. Martini A reabsorbable tubular chamber for the treatment of large diaphyseal bone defects. Experimental study in rabbits Int. J. Artif. Organs. 21 1998 473 482
8. Giavaresi G, Tschon M, Daly JH, Liggat JJ, Fini M, Torricelli P, et al. Natural and synthetic polyesters for musculoskeletal tissue repair: experimental in vitro and in vivo evaluations. Int. J. Artif. Organs (in press).
9. S. Gogolewski, M. Jovanovic, S. Perren, J. Dillon, and M. Hughes Tissue response and in vivo degradation of selected polyhydroxyacids: polylactides (PLA), poly(3-hydroxybutyrate) (PHB), and poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHB/VA) J. Biomed. Mater. Res. 27 1993 1135 1148
10. I. Gursel, and V. Hasirci Properties and drug release behaviour of poly(3-hydroxybutyric acid) and various poly(3-hydroxybutyrate-hydroxyvalerate) copolymer microcapsules J. Microencapsul. 12 1995 185 193
11. I. Gursel, F. Korkusuz, F. Turesin, N. Alaeddinoglu, and V. Hasirci In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis Biomaterials 22 2001 73 80
12. I. Gursel, F. Yagmurlu, F. Korkusuz, and V. Hasirci In vitro antibiotic release from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) rods J. Microencapsul. 19 2002 153 164
13. K. Hendricks, D. Lane, T. Burd, K. Lowry, D. Day, and J. Phaup Elution characteristics of tobramycin from polycaprolactone in a rabbit model Clin. Orthop. Rel. Res. 392 2001 418 426
14. S. Holland, A. Jolly, M. Yasin, and B. Tighe Polymers for biodegradable medical devices. II. Hydroxybutyrate-hydroxyvalerate copolymers: hydrolytic degradation studies Biomaterials 8 1987 289 295
15. S. Humphrey, S. Mehta, A. Seaber, and V. Parker Pharmacokinetics of a degradable drug delivery system in bone Clin. Orthop. 349 1998 218 224
16. G. Khang, S. Kim, J. Cho, J. Rhee, S. Yoon, and H. Lee Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microspheres for the sustained release of 5-fluorouracil Biomed Mater Eng. 11 2001 89 103
17. A. Lavasanifar, J. Samuel, and G. Kwon Poly(ethylene oxide)-block-poly(l- amino acid) micelles for drug delivery Adv. Drug. Deliv. Rev. 54 2002 169 190
18. A. Lucke, J. Teßmar, E. Schnell, G. Schmeer, and A. Göpferich Biodegradable poly(d,l-lactic acid)-poly(ethylene glycol)-mono-methyl ether diblock copolymers: structures and surface properties relevant to their use as biomaterials Biomaterials 21 2000 2361 2370
19. J. Mader, C. Stevens, J. Stevens, R. Ruble, J. Lathrop, and J. Calhoun Treatment of experimental osteomyelitis with a fibrin sealant antibiotic implant Clin. Orthop. Rel. Res. 403 2002 58 72
20. M. Mattioli-Belmonte, G. Giavaresi, G. Biagini, L. Virgili, M. Giacomini, and M. Fini Tailoring biomaterial compatibility: in vivo tissue response versus in vitro cell behaviour Int. J. Artif. Organs. 26 2003 1077 1085
21. R. Palmgren, S. Karlsson, and A.-C. Albertsson Synthesis of degradable crosslinked polymers based on 1,5-dioxepan-2-one and crosslinker of bis-ε-caprolactone type J. Polym. Sci. A: Polym. Chem. 35 1997 1635 1649
22. J. Panyam, and V. Labhasetwar Biodegradable nanoparticles for drug and gene delivery to cells and tissue Adv. Drug. Deliv. Rev. 55 2003 329 347
23. B. Rutledge, D. Huyette, D. Day, and J. Anglen Treatment of osteomyelitis with local antibiotics delivered via bioadsorbable polymer Clin. Orthop. Rel. Res. 411 2003 280 287
24. M. Ryner, and A. Albertsson Resorbable and highly elastic block copolymers from 1 to 5 dioxepan-one and l-lactide with controlled tensile properties and hydrophilicity Biomacromolecules 3 2002 601 608
25. T. Saito, K. Tomita, K. Juni, and K. Ooba In vivo and in vitro degradation of poly(3-hydroxybutyrate) in rat Biomaterials 12 1991 309 312
26. S. Schwendeman Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems Crit. Rev. Ther. Drug. Carrier Syst. 19 2002 73 98
27. D. Sendil, I. Gursel, D. Wise, and V. Hasirci Antibiotic release from biodegradable PHBV microparticles J. Control. Release 59 1999 207 217
28. M. Shirtliff, J. Calhoun, and J. Mader Experimental osteomyelitis treatment with antibiotic-impregnated hydroxyapatite Clin. Orthop. Rel. Res. 401 2002 239 247
29. L. Tang, and J. Eaton Inflammatory responses to biomaterials Am. J. Clin. Pathol. 103 1995 466 471
30. F. Turesin, I. Gursel, and V. Hasirci Biodegradable polyhydroxyalkanoate implants for osteomyelitis therapy: in vitro antibiotic release J. Biomater Sci. Polym. Ed. 12 2001 195 207
31. G. Van der Walle, G. de Koning, R. Weusthuis, and G. Eggink Properties, modifications and applications of biopolyesters Adv. Biochem. Eng. Biotechnol. 71 2001 263 291
32. F. Veronese, F. Marsilio, P. Caliceti, P. De Filippis, P. Giunchedi, and S. Lora Polyorganophosphazene microspheres for drug release: polymer synthesis, microsphere preparation, in vitro and in vivo naproxen release J. Control. Release 52 1998 227 237
33. Y. Wang, W. Chen, J. Yang, J. Bei, and S. Wang Biodegradable poly(l-lactide)-poly(ethylene glycol) multiblock copolymer: synthesis and evaluation of cell affinity Biomaterials 24 2003 2195 2203
34. S. Woodward, and T. Salthouse The tissue resposne to implants and its evaluation by light microscopy A. Von Recum Handbook of Biomaterials Evaluation 1986 Macmillian Publishing Company NY 364 378
35. M. Yagmurlu, F. Korkusuz, I. Gursel, P. Korkusuz, U. Ors, and V. Hasirci Sulbactam-cefoperazone polyhydroxybutyrate-co-hydroxyvalerate (PHBV) local antibiotic delivery system: in vivo effectiveness and biocompatibility in the treatment of implant-related experimental osteomyelitis J. Biomed. Mater. Res. 46 1999 494 503
36. M. Yasin, S. Holland, and B. Tighe Polymers for biodegradable medical devices. V. Hydroxybutyrate-hydroxyvalerate copolymers: effects of polymer processing on hydrolytic degradation Biomaterials 11 1990 451 454