On the mechanisms that limit oxygen uptake during exercise in acute and chronic hypoxia: Role of muscle mass

Journal of Physiology

Volumn 587, Issue 2, 2009, Pages 477-490

  Calbet, José A L ^a,b   Rådegran, Göran ^a,d   Boushel, Robert ^a,c   Saltin, Bengt ^a  

^a International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^b UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALTITUDE ACCLIMATIZATION; ARTERIAL OXYGEN TENSION; ARTERIAL PRESSURE; ARTICLE; BICYCLE ERGOMETRY; BLOOD ANALYSIS; BLOOD GAS; CATHETERIZATION; EXERCISE; FEMALE; HEART OUTPUT; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LEG BLOOD FLOW; LUNG GAS EXCHANGE; MALE; MUSCLE MASS; NORMAL HUMAN; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PRIORITY JOURNAL; ACUTE HYPOXIA; BLOOD FLOW; CHRONIC HYPOXIA; CONTROLLED STUDY;

ACCLIMATIZATION; ACUTE DISEASE; ADULT; ALTITUDE; ANOXIA; BLOOD PRESSURE; CARBON DIOXIDE; CARDIAC OUTPUT; CATECHOLAMINES; CHRONIC DISEASE; EXERCISE; EXERCISE TEST; FEMALE; FEMORAL VEIN; HUMANS; LEG; MALE; MUSCLE, SKELETAL; OXYGEN; PARTIAL PRESSURE; PULMONARY GAS EXCHANGE; PULMONARY VENTILATION; REGIONAL BLOOD FLOW; YOUNG ADULT;

EID: 58349087882     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.162271     Document Type: Article

References (55)

1. Amann M & Calbet JA (2008). Convective oxygen transport and fatigue. J Appl Physiol 104, 861-870.
2. Amann M & Dempsey JA (2008). The concept of peripheral locomotor muscle fatigue as a regulated variable. J Physiol (in press).
3. Amann M, Eldridge MW, Lovering AT, Stickland MK, Pegelow DF & Dempsey JA (2006). Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J Physiol 575, 937-952.
4. Amann M, Proctor LT, Sebranek JJ, Eldridge MW, Pegelow DF & Dempsey JA (2008 a). Somatosensory feedback from the limbs exerts inhibitory influences on central neural drive during whole body endurance exercise. J Appl Physiol 1059, 1714-1724.
5. Amann M, Proctor LT, Sebranek JJ, Pegelow DF & Dempsey JA (2008 b). Opioid-mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humans. J Physiol (in press).
6. Andersen P & Saltin B (1985). Maximal perfusion of skeletal muscle in man. J Physiol 366, 233-249.
7. Asmussen E & Nielsen M (1946). Studies on the regulation of respiration in heavy work. Acta Physiol Scand 12, 171-188.
8. Bebout DE, Story D, Roca J, Hogan MC, Poole DC, Gonzalez-Camarena R, Ueno O, Haab P & Wagner PD (1989). Effects of altitude acclimatization on pulmonary gas exchange during exercise. J Appl Physiol 67, 2286-2295.
9. Boushel R, Calbet JA, Radegran G, Sondergaard H, Wagner PD & Saltin B (2001). Parasympathetic neural activity accounts for the lowering of exercise heart rate at high altitude. Circulation 104, 1785-1791.
10. Calbet JA (2003). Chronic hypoxia increases blood pressure and noradrenaline spillover in healthy humans. J Physiol 551, 379-386.
11. Calbet JA, Boushel R, Radegran G, Sondergaard H, Wagner PD & Saltin B (2003 a). Determinants of maximal oxygen uptake in severe acute hypoxia. Am J Physiol Regul Integr Comp Physiol 284, R291-R303.
12. 2 content? Am J Physiol Regul Integr Comp Physiol 284, R304-R316.
13. Calbet JA, De Paz JA, Garatachea N, Cabeza De Vaca S & Chavarren J (2003 c). Anaerobic energy provision does not limit Wingate exercise performance in endurance-trained cyclists. J Appl Physiol 94, 668-676.
14. Calbet JA, Jensen-Urstad M, Van Hall G, Holmberg HC, Rosdahl H & Saltin B (2004 a). Maximal muscular vascular conductances during whole body upright exercise in humans. J Physiol 558, 319-331.
15. Calbet JA, Radegran G, Boushel R, Sondergaard H, Saltin B & Wagner PD (2002). Effect of blood haemoglobin concentration on and cardiovascular function in lowlanders acclimatised to 5260 m. J Physiol 545, 715-728.
16. Calbet JA, Radegran G, Boushel R, Sondergaard H, Saltin B & Wagner PD (2004 b). Plasma volume expansion does not increase maximal cardiac output or in lowlanders acclimatized to altitude. Am J Physiol Heart Circ Physiol 287, H1214-H1224.
17. Calbet JA, Robach P, Lundby C & Boushel R (2008). Is pulmonary gas exchange during exercise in hypoxia impaired with the increase of cardiac output? Appl Physiol Nutr Metab 33, 593-600.
18. Cerretelli P (1976). Limiting factors to oxygen transport on Mount Everest. J Appl Physiol 40, 658-667.
19. Dow P (1956). Estimations of cardiac output and central blood volume by dye dilution. Physiol Rev 36, 77-102.
20. Ekblom B, Wilson G & Astrand PO (1976). Central circulation during exercise after venesection and reinfusion of red blood cells. J Appl Physiol 40, 379-383.
21. Fulco CS, Lewis SF, Frykman PN, Boushel R, Smith S, Harman EA, Cymerman A & Pandolf KB (1996). Muscle fatigue and exhaustion during dynamic leg exercise in normoxia and hypobaric hypoxia. J Appl Physiol 81, 1891-1900.
22. Galbo H, Kjaer M & Secher NH (1987). Cardiovascular, ventilatory and catecholamine responses to maximal dynamic exercise in partially curarized man. J Physiol 389, 557-568.
23. Gale GE, Torre-Bueno JR, Moon RE, Saltzman HA & Wagner PD (1985). Ventilation-perfusion inequality in normal humans during exercise at sea level and simulated altitude. J Appl Physiol 58, 978-988.
24. Garner SH, Sutton JR, Burse RL, McComas AJ, Cymerman A & Houston CS (1990). Operation Everest II: Neuromuscular performance under conditions of extreme simulated altitude. J Appl Physiol 68, 1167-1172.
25. Hallman H, Farnebo LO, Hamberger B & Johnsson G (1978). A sensitive method for the determination of plasma catecholamines using liquid chromatography with electrochemical detection. Life Sci 23, 1049-1052.
26. Hammond MD, Gale GE, Kapitan KS, Ries A & Wagner PD (1986). Pulmonary gas exchange in humans during normobaric hypoxic exercise. J Appl Physiol 61, 1749-1757.
27. Holmberg HC & Calbet JAL (2007). Insufficient ventilation as a cause of impaired pulmonary gas exchange during submaximal exercise. Respir Physiol Neurobiol 157, 348-359.
28. Hopkins SR, Barker RC, Brutsaert TD, Gavin TP, Entin P, Olfert IM, Veisel S & Wagner PD (2000). Pulmonary gas exchange during exercise in women: Effects of exercise type and work increment. J Appl Physiol 89, 721-730.
29. Hopkins SR, Belzberg AS, Wiggs BR & McKenzie DC (1996). Pulmonary transit time and diffusion limitation during heavy exercise in athletes. Respir Physiol 103, 67-73.
30. Hopkins SR, Gavin TP, Siafakas NM, Haseler LJ, Olfert IM, Wagner H & Wagner PD (1998). Effect of prolonged, heavy exercise on pulmonary gas exchange in athletes. J Appl Physiol 85, 1523-1532.
31. Hopkins SR, McKenzie DC, Schoene RB, Glenny RW & Robertson HT (1994). Pulmonary gas exchange during exercise in athletes. I. Ventilation-perfusion mismatch and diffusion limitation. J Appl Physiol 77, 912-917.
32. Koskolou MD, Calbet JA, Radegran G & Roach RC (1997 a). Hypoxia and the cardiovascular response to dynamic knee-extensor exercise. Am J Physiol Heart Circ Physiol 272, H2655-H2663.
33. Koskolou MD, Roach RC, Calbet JA, Radegran G & Saltin B (1997 b). Cardiovascular responses to dynamic exercise with acute anemia in humans. Am J Physiol Heart Circ Physiol 273, H1787-H1793.
34. 2 demand at the microcirculatory level. J Physiol 586, 123-130.
35. Lundby C, Calbet JA, van Hall G, Saltin B & Sander M (2004). Pulmonary gas exchange at maximal exercise in Danish lowlanders during 8 wk of acclimatization to 4,100 m and in high-altitude Aymara natives. Am J Physiol Regul Integr Comp Physiol 287, R1202-R1208.
36. Lundby C, Robach P, Boushel R, Thomsen JJ, Rasmussen P, Koskolou M & Calbet JA (2008 b). Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport? J Appl Physiol 105, 581-587.
37. Lundby C, Sander M, van Hall G, Saltin B & Calbet JA (2006). Maximal exercise and muscle oxygen extraction in acclimatizing lowlanders and in high altitude natives. J Physiol 573, 535-547.
38. Mizuno M, Savard GK, Areskog N-H, Lundby C & Saltin B (2008). Skeletal muscle adaptations to prolonged exposure to extreme altitude: A role of physical activity? High Alt Med Biol (in press).
39. Piepoli M, Clark AL & Coats AJ (1995). Muscle metaboreceptors in hemodynamic, autonomic, and ventilatory responses to exercise in men. Am J Physiol Heart Circ Physiol 269, H1428-H1436.
40. Pugh LGCE (1964). Cardiac output in muscular exercise at 5800 m. (19000 ft). J Appl Physiol 19, 441-447.
41. Rådegran G, Blomstrand E & Saltin B (1999). Peak muscle perfusion and oxygen uptake in humans: Importance of precise estimates of muscle mass. J Appl Physiol 87, 2375-2380.
42. Reeves JT, Groves BM, Sutton JR, Wagner PD, Cymerman A, Malconian MK, Rock PB, Young PM & Houston CS (1987). Operation Everest II: preservation of cardiac function at extreme altitude. J Appl Physiol 63, 531-539.
43. 2 during single leg knee-extensor exercise in humans. Am J Physiol Heart Circ Physiol 268, H1453-H1461.
44. 2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans. Am J Physiol Heart Circ Physiol 276, H438-H445.
45. Savard GK, Areskog NH & Saltin B (1996). Maximal muscle activation is not limited by pulmonary ventilation in chronic hypoxia. Acta Physiol Scand 157, 187-190.
46. Savard GK, Richter EA, Strange S, Kiens B, Christensen NJ & Saltin B (1989). Norepinephrine spillover from skeletal muscle during exercise in humans: Role of muscle mass. Am J Physiol Heart Circ Physiol 257, H1812-H1818.
47. Stenberg J, Ekblom B & Messin R (1966). Hemodynamic response to work at simulated altitude, 4,000 m. J Appl Physiol 21, 1589-1594.
48. Strange S, Secher NH, Pawelczyk JA, Karpakka J, Christensen NJ, Mitchell JH & Saltin B (1993). Neural control of cardiovascular responses and of ventilation during dynamic exercise in man. J Physiol 470, 693-704.
49. Sun MK & Reis DJ (1994). Central neural mechanisms mediating excitation of sympathetic neurons by hypoxia. Prog Neurobiol 44, 197-219.
50. Torre-Bueno JR, Wagner PD, Saltzman HA, Gale GE & Moon RE (1985). Diffusion limitation in normal humans during exercise at sea level and simulated altitude. J Appl Physiol 58, 989-995.
51. Vogiatzis I, Zakynthinos S, Boushel R, Athanasopoulos D, Guenette JA, Wagner H, Roussos C & Wagner PD (2008). The contribution of intrapulmonary shunts to the alveolar-to-arterial oxygen difference during exercise is very small. J Physiol 586, 2381-2391.
52. 2, max. Respir Physiol 93, 221-237.
53. 2 max. Exerc Sport Sci Rev 28, 10-14.
54. Wagner PD, Araoz M, Boushel R, Calbet JA, Jessen B, Radegran G, Spielvogel H, Sondegaard H, Wagner H & Saltin B (2002). Pulmonary gas exchange and acid-base state at 5,260 m in high-altitude Bolivians and acclimatized lowlanders. J Appl Physiol 92, 1393-1400.
55. Zanzinger J, Czachurski J & Seller H (1998). Nitric oxide in the ventrolateral medulla regulates sympathetic responses to systemic hypoxia in pigs. Am J Physiol Regul Integr Comp Physiol 275, R33-R39.