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Volumn 321, Issue 1-2, 2009, Pages 23-35

Hypoxia-induced regulation of nitric oxide synthase in cardiac endothelial cells and myocytes and the role of the PI3-K/PKB pathway

Author keywords

Cardiac endothelial cells; Cardiomyocytes; eNOS; Hypoxia; iNOS; Nitric oxide; PKB

Indexed keywords

4,5 DIAMINOFLUORESCEIN DIACETATE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; WORTMANNIN;

EID: 58249126954     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9906-2     Document Type: Article
Times cited : (26)

References (53)
  • 1
    • 29444432915 scopus 로고    scopus 로고
    • The ubiquitous role of nitric oxide in cardioprotection
    • doi: 10.1016/j.yjmcc.2005.09.011
    • Jones SP, Bolli R (2006) The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol 40:16-23. doi: 10.1016/ j.yjmcc.2005.09.011
    • (2006) J Mol Cell Cardiol , vol.40 , pp. 16-23
    • Jones, S.P.1    Bolli, R.2
  • 2
    • 0034069386 scopus 로고    scopus 로고
    • Paracrine and autocrine effects of nitric oxide on myocardial function
    • doi: 10.1016/S0163-7258(99)00072-8
    • Shah AM, MacCarthy PA (2000) Paracrine and autocrine effects of nitric oxide on myocardial function. Pharmacol Ther 86:49-86. doi: 10.1016/ S0163-7258(99)00072-8
    • (2000) Pharmacol Ther , vol.86 , pp. 49-86
    • Shah, A.M.1    MacCarthy, P.A.2
  • 3
    • 1142285456 scopus 로고    scopus 로고
    • Nitric oxide in myocardial ischemia/reperfusion injury
    • doi: 10.1016/j.cardiores.2003.09.019
    • Schulz R, Kelm M, Heusch G (2004) Nitric oxide in myocardial ischemia/ reperfusion injury. Cardiovasc Res 61:402-413. doi: 10.1016/ j.cardiores.2003.09.019
    • (2004) Cardiovasc Res , vol.61 , pp. 402-413
    • Schulz, R.1    Kelm, M.2    Heusch, G.3
  • 4
    • 33646400011 scopus 로고    scopus 로고
    • Peroxynitrite: Just an oxidative/nitrosative stressor or a physiological regulator as well?
    • doi: 10.1038/sj.bjp.0706693
    • Ferdinandy P (2006) Peroxynitrite: Just an oxidative/nitrosative stressor or a physiological regulator as well? Br J Pharmacol 148:1-3. doi: 10.1038/sj.bjp.0706693
    • (2006) Br J Pharmacol , vol.148 , pp. 1-3
    • Ferdinandy, P.1
  • 5
    • 0032076220 scopus 로고    scopus 로고
    • Cardiac endothelium and myocardial function
    • doi: 10.1016/S0008-6363(98)00044-3
    • Brutsaert DL, Franken P, Andries LJ et al (1998) Cardiac endothelium and myocardial function. Cardiovasc Res 38:281-290. doi: 10.1016/ S0008-6363(98)00044-3
    • (1998) Cardiovasc Res , vol.38 , pp. 281-290
    • Brutsaert, D.L.1    Franken, P.2    Andries, L.J.3
  • 6
    • 0032498529 scopus 로고    scopus 로고
    • Nonuniformity of endothelial nitric oxide synthase distribution in cardiac endothelium
    • Andries LJ, Brutsaert DL, Sys SU (1998) Nonuniformity of endothelial nitric oxide synthase distribution in cardiac endothelium. Circ Res 82:195-203
    • (1998) Circ Res , vol.82 , pp. 195-203
    • Andries, L.J.1    Brutsaert, D.L.2    Sys, S.U.3
  • 7
    • 0029057806 scopus 로고
    • Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes
    • doi: 10.1074/jbc.270.47.28471
    • Balligand JL, Kobzik L, Han X et al (1995) Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J Biol Chem 270:14582-14586. doi: 10.1074/jbc.270.47.28471
    • (1995) J Biol Chem , vol.270 , pp. 14582-14586
    • Balligand, J.L.1    Kobzik, L.2    Han, X.3
  • 8
    • 0028955311 scopus 로고
    • Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1β and IFN-γ
    • Balligand JL, Ungureanu-Longrois D, Simmons WW et al (1995) Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1β and IFN-γ. Am J Physiol 269:H1293-H1303
    • (1995) Am J Physiol , vol.269
    • Balligand, J.L.1    Ungureanu-Longrois, D.2    Simmons, W.W.3
  • 9
    • 0028135094 scopus 로고
    • Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro
    • Balligand JL, Ungureanu-Longrois D, Simmons WW et al (1994) Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J Biol Chem 269:27580-27588
    • (1994) J Biol Chem , vol.269 , pp. 27580-27588
    • Balligand, J.L.1    Ungureanu-Longrois, D.2    Simmons, W.W.3
  • 10
    • 15244362284 scopus 로고    scopus 로고
    • Cardiac nitric oxide: Emerging role for nNOS in regulating physiological function
    • doi: 10.1016/j.pharmthera.2004.11.003
    • Danson EJ, Choate JK, Paterson DJ (2005) Cardiac nitric oxide: Emerging role for nNOS in regulating physiological function. Pharmacol Ther 106:57-74. doi: 10.1016/j.pharmthera.2004.11.003
    • (2005) Pharmacol Ther , vol.106 , pp. 57-74
    • Danson, E.J.1    Choate, J.K.2    Paterson, D.J.3
  • 11
    • 0037786972 scopus 로고    scopus 로고
    • The real estate of NOS signaling
    • doi: 10.1161/01.RES.0000080783.34092.AF
    • Ziolo MT, Bers DM (2003) The real estate of NOS signaling. Circ Res 92:1279-1281. doi: 10.1161/01.RES.0000080783.34092.AF
    • (2003) Circ Res , vol.92 , pp. 1279-1281
    • Ziolo, M.T.1    Bers, D.M.2
  • 12
    • 0031048389 scopus 로고    scopus 로고
    • Nitric oxide, the biological mediator of the decade: Fact or fiction?
    • Singh S, Evans TW (1997) Nitric oxide, the biological mediator of the decade: Fact or fiction? Eur Respir J 10:699-707
    • (1997) Eur Respir J , vol.10 , pp. 699-707
    • Singh, S.1    Evans, T.W.2
  • 13
    • 0031439772 scopus 로고    scopus 로고
    • Nitric oxide synthases and cardiac muscle. Autocrine and paracrine influences
    • Balligand JL, Cannon PJ (1997) Nitric oxide synthases and cardiac muscle. Autocrine and paracrine influences. Arterioscler Thromb Vasc Biol 17:1846-1858
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 1846-1858
    • Balligand, J.L.1    Cannon, P.J.2
  • 14
    • 0037207468 scopus 로고    scopus 로고
    • Cardiac endothelial-myocardial signaling: Its role in cardiac growth, contractile performance and rhythmicity
    • Brutsaert DL (2003) Cardiac endothelial-myocardial signaling: Its role in cardiac growth, contractile performance and rhythmicity. Physiol Rev 83:59-115
    • (2003) Physiol Rev , vol.83 , pp. 59-115
    • Brutsaert, D.L.1
  • 15
    • 33644931611 scopus 로고    scopus 로고
    • Nitric oxide production is higher in rat cardiac microvessel endothelial cells than ventricular cardiomyocytes in baseline and hypoxic conditions: A comparative study
    • Strijdom H, Jacobs S, Hattingh S et al (2006) Nitric oxide production is higher in rat cardiac microvessel endothelial cells than ventricular cardiomyocytes in baseline and hypoxic conditions: A comparative study. FASEB J 20:14-316
    • (2006) FASEB J , vol.20 , pp. 14-316
    • Strijdom, H.1    Jacobs, S.2    Hattingh, S.3
  • 16
    • 0344146411 scopus 로고    scopus 로고
    • Classic preconditioning decreases the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts
    • Csonka C, Szilvassy Z, Fulop F et al (1999) Classic preconditioning decreases the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts. Circulation 100:2260-2266
    • (1999) Circulation , vol.100 , pp. 2260-2266
    • Csonka, C.1    Szilvassy, Z.2    Fulop, F.3
  • 17
    • 0028985256 scopus 로고
    • Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy
    • doi: 10.1074/jbc.270.32.18797
    • Zweier JL, Wang P, Kuppusamy P (1995) Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy. J Biol Chem 270:304-307. doi: 10.1074/jbc.270.32.18797
    • (1995) J Biol Chem , vol.270 , pp. 304-307
    • Zweier, J.L.1    Wang, P.2    Kuppusamy, P.3
  • 18
    • 0031023395 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase by ischaemia in the perfused heart
    • doi: 10.1016/S0008-6363(96)00176-9
    • Depré C, Fierain L, Hue L (1997) Activation of nitric oxide synthase by ischaemia in the perfused heart. Cardiovasc Res 33:82-87. doi: 10.1016/S0008-6363(96)00176-9
    • (1997) Cardiovasc Res , vol.33 , pp. 82-87
    • Depré, C.1    Fierain, L.2    Hue, L.3
  • 19
    • 0029044895 scopus 로고
    • Plasma nitric oxide end products are increased in the ischemic canine heart
    • doi: 10.1006/bbrc.1995.1823
    • Node K, Kitakaze M, Kosaka H et al (1995) Plasma nitric oxide end products are increased in the ischemic canine heart. Biochem Biophys Res Commun 211:370-374. doi: 10.1006/bbrc.1995.1823
    • (1995) Biochem Biophys Res Commun , vol.211 , pp. 370-374
    • Node, K.1    Kitakaze, M.2    Kosaka, H.3
  • 20
    • 0033976342 scopus 로고    scopus 로고
    • Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes
    • Jung F, Palmer, Zhou N, Johns RA (2000) Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes. Circ Res 86:319-325
    • (2000) Circ Res , vol.86 , pp. 319-325
    • Jung, F.1    Palmer2    Zhou, N.3    Johns, R.A.4
  • 21
    • 4544301418 scopus 로고    scopus 로고
    • Direct intracellular nitric oxide (NO) detection in isolated adult cardiomyocytes: Flow cytometric analysis using the fluorescent probe, diaminofluorescein (DAF)
    • doi: 10.1016/j.yjmcc.2004.05.018
    • Strijdom H, Muller C, Lochner A (2004) Direct intracellular nitric oxide (NO) detection in isolated adult cardiomyocytes: Flow cytometric analysis using the fluorescent probe, diaminofluorescein (DAF). J Mol Cell Cardiol 37:897-902. doi: 10.1016/j.yjmcc.2004.05.018
    • (2004) J Mol Cell Cardiol , vol.37 , pp. 897-902
    • Strijdom, H.1    Muller, C.2    Lochner, A.3
  • 22
    • 0028828726 scopus 로고
    • Evidence for nitric oxide generation in the cardiomyocytes: Its augmentation by hypoxia
    • doi: 10.1016/S0022-2828(95)91335-1
    • Kitakaze M, Node K, Komamura K et al (1995) Evidence for nitric oxide generation in the cardiomyocytes: Its augmentation by hypoxia. J Mol Cell Cardiol 27:2149-2154. doi: 10.1016/S0022-2828(95)91335-1
    • (1995) J Mol Cell Cardiol , vol.27 , pp. 2149-2154
    • Kitakaze, M.1    Node, K.2    Komamura, K.3
  • 23
    • 3342973841 scopus 로고    scopus 로고
    • Nitric oxide synthase (NOS) does not contribute to simulated ischaemic preconditioning in an isolated rat cardiomyocyte model
    • doi: 10.1023/B:CARD.0000029027.50796.84
    • Strijdom H, Genade S, Lochner A (2004) Nitric oxide synthase (NOS) does not contribute to simulated ischaemic preconditioning in an isolated rat cardiomyocyte model. Cardiovasc Drugs Ther 18:99-112. doi: 10.1023/ B:CARD.0000029027.50796.84
    • (2004) Cardiovasc Drugs Ther , vol.18 , pp. 99-112
    • Strijdom, H.1    Genade, S.2    Lochner, A.3
  • 24
    • 0033966770 scopus 로고    scopus 로고
    • Endothelial cell regulation of nitric oxide production during hypoxia in coronary microvessels and epicardial arteries
    • doi:10.1002/(SICI)1097-4652(200003)182:3<359::AID-JCP6>3.0.CO;2-3
    • Justice JM, Tanner MA, Myers PR (2000) Endothelial cell regulation of nitric oxide production during hypoxia in coronary microvessels and epicardial arteries. J Cell Physiol 182:359-365. doi:10.1002/ (SICI)1097-4652(200003)182:3<359::AID-JCP6>3.0.CO;2-3
    • (2000) J Cell Physiol , vol.182 , pp. 359-365
    • Justice, J.M.1    Tanner, M.A.2    Myers, P.R.3
  • 25
    • 1542609163 scopus 로고    scopus 로고
    • Hypoxia increases Hsp90 binding to eNOS via PI3-K-Akt in porcine coronary artery endothelium
    • doi: 10.1038/labinvest.3700027
    • Chen JX, Meyrick B (2004) Hypoxia increases Hsp90 binding to eNOS via PI3-K-Akt in porcine coronary artery endothelium. Lab Invest 84:182-190. doi: 10.1038/labinvest.3700027
    • (2004) Lab Invest , vol.84 , pp. 182-190
    • Chen, J.X.1    Meyrick, B.2
  • 26
    • 0027938194 scopus 로고
    • Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms
    • McQuillan LP, Leung GK, Marsden PA et al (1994) Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. Am J Physiol 5:H1921-H1927
    • (1994) Am J Physiol , vol.5
    • McQuillan, L.P.1    Leung, G.K.2    Marsden, P.A.3
  • 27
    • 0026040552 scopus 로고
    • Highly insulin-responsive isolated rat heart muscle cells yielded by a modified isolation method
    • doi: 10.1016/0024-3205(91)90310-8
    • Fischer Y, Rose H, Kammermeier H (1991) Highly insulin-responsive isolated rat heart muscle cells yielded by a modified isolation method. Life Sci 49:1679-1688. doi: 10.1016/0024-3205(91)90310-8
    • (1991) Life Sci , vol.49 , pp. 1679-1688
    • Fischer, Y.1    Rose, H.2    Kammermeier, H.3
  • 28
    • 0027468890 scopus 로고
    • Isolation and characterization of human and rat cardiac microvascular endothelial cells
    • Nishida M, Carley WW, Gerritsen ME et al (1993) Isolation and characterization of human and rat cardiac microvascular endothelial cells. Am J Physiol Heart Circ Physiol 33:H639-H652
    • (1993) Am J Physiol Heart Circ Physiol , vol.33
    • Nishida, M.1    Carley, W.W.2    Gerritsen, M.E.3
  • 30
    • 85047680361 scopus 로고
    • Preconditioning of isolated rabbit cardiomyocytes: Induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor
    • doi: 10.1093/cvr/28.1.72
    • Armstrong S, Downey JM, Ganote CE (1994) Preconditioning of isolated rabbit cardiomyocytes: Induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor. Cardiovasc Res 28:72-77. doi: 10.1093/cvr/28.1.72
    • (1994) Cardiovasc Res , vol.28 , pp. 72-77
    • Armstrong, S.1    Downey, J.M.2    Ganote, C.E.3
  • 31
    • 0035347302 scopus 로고    scopus 로고
    • Formation of peroxynitrite in vascular endothelial cells exposed to cyclosporine A
    • Navarro-Antolin J, Lopes-Munoz MJ, Klatt P et al (2001) Formation of peroxynitrite in vascular endothelial cells exposed to cyclosporine A. FASEB J 15:1291-1293
    • (2001) FASEB J , vol.15 , pp. 1291-1293
    • Navarro-Antolin, J.1    Lopes-Munoz, M.J.2    Klatt, P.3
  • 32
    • 0346244001 scopus 로고    scopus 로고
    • Intracellular phospho-protein staining techniques for flow cytometry: Monitoring single cell signaling events
    • doi: 10.1002/cyto.a.10072
    • Krutzik PO, Nolan GP (2003) Intracellular phospho-protein staining techniques for flow cytometry: Monitoring single cell signaling events. Cytometry A 55:61-70. doi: 10.1002/cyto.a.10072
    • (2003) Cytometry A , vol.55 , pp. 61-70
    • Krutzik, P.O.1    Nolan, G.P.2
  • 33
    • 2642563776 scopus 로고    scopus 로고
    • A new role for monamine oxidases in the modulation of macrophage-inducible nitric oxide synthase gene expression
    • doi: 10.1189/jlb.1003459
    • Vega A, Chacon P, Monteseirin J et al (2004) A new role for monamine oxidases in the modulation of macrophage-inducible nitric oxide synthase gene expression. J Leukoc Biol 75:1093-1101. doi: 10.1189/jlb.1003459
    • (2004) J Leukoc Biol , vol.75 , pp. 1093-1101
    • Vega, A.1    Chacon, P.2    Monteseirin, J.3
  • 34
    • 0036484303 scopus 로고    scopus 로고
    • Relaxin up-regulates inducible nitric oxide synthase expression and nitric oxide generation in rat coronary endothelial cells
    • Failli P, Nistri S, Quattrone S et al (2002) Relaxin up-regulates inducible nitric oxide synthase expression and nitric oxide generation in rat coronary endothelial cells. FASEB J 16:252-254
    • (2002) FASEB J , vol.16 , pp. 252-254
    • Failli, P.1    Nistri, S.2    Quattrone, S.3
  • 35
    • 0035812887 scopus 로고    scopus 로고
    • Reliable in vitro measurement of nitric oxide released from endothelial cells using low concentrations of the fluorescent probe 4, 5-diaminofluorescein
    • doi: 10.1016/S0014-5793(01)02901-5
    • Leikert JF, Räthel TR, Müller C et al (2001) Reliable in vitro measurement of nitric oxide released from endothelial cells using low concentrations of the fluorescent probe 4, 5-diaminofluorescein. FEBS Lett 506:131-134. doi: 10.1016/S0014-5793(01)02901-5
    • (2001) FEBS Lett , vol.506 , pp. 131-134
    • Leikert, J.F.1    Räthel, T.R.2    Müller, C.3
  • 36
    • 0036710557 scopus 로고    scopus 로고
    • Increased nitric oxide-dependent nitrosylation of 4, 5-diaminofluorescein by oxidants: Implications for the measurement of intracellular nitric oxide
    • doi: 10.1016/S0891-5849(02)00955-3
    • Jourd'heuil D (2002) Increased nitric oxide-dependent nitrosylation of 4, 5-diaminofluorescein by oxidants: Implications for the measurement of intracellular nitric oxide. Free Radic Biol Med 33:676-684. doi: 10.1016/ S0891-5849(02)00955-3
    • (2002) Free Radic Biol Med , vol.33 , pp. 676-684
    • Jourd'heuil, D.1
  • 37
    • 33845573616 scopus 로고    scopus 로고
    • Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes
    • doi: 10.1096/fj.06-5717fje
    • Liao X, Liu JM, Du L et al (2006) Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes. FASEB J 20:1883-1885. doi: 10.1096/fj.06-5717fje
    • (2006) FASEB J , vol.20 , pp. 1883-1885
    • Liao, X.1    Liu, J.M.2    Du, L.3
  • 38
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • doi: 10.1152/physrev.00029.2006
    • Pacher P, Beckman JS, Liaudet L (2007) Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87:315-424. doi: 10.1152/ physrev.00029.2006
    • (2007) Physiol Rev , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 39
    • 34447108754 scopus 로고    scopus 로고
    • Arginine vasopressin increases iNOS-NO system activity in cardiac fibroblasts through NF-kappaB activation and its relation with myocardial fibrosis
    • doi: 10.1016/j.lfs.2007.05.018
    • Fan YH, Zhao LY, Zheng QS et al (2007) Arginine vasopressin increases iNOS-NO system activity in cardiac fibroblasts through NF-kappaB activation and its relation with myocardial fibrosis. Life Sci 81(4):327-335. doi: 10.1016/j.lfs.2007.05.018
    • (2007) Life Sci , vol.81 , Issue.4 , pp. 327-335
    • Fan, Y.H.1    Zhao, L.Y.2    Zheng, Q.S.3
  • 40
    • 0037230180 scopus 로고    scopus 로고
    • ROS and NO trigger early preconditioning: Relationship to mitochondrial KATP channel
    • Lebuffe G, Schumacker PT, Shao ZH et al (2003) ROS and NO trigger early preconditioning: Relationship to mitochondrial KATP channel. Am J Physiol Heart Circ Physiol 284(1):H299-H308
    • (2003) Am J Physiol Heart Circ Physiol , vol.284 , Issue.1
    • Lebuffe, G.1    Schumacker, P.T.2    Shao, Z.H.3
  • 41
    • 29444436958 scopus 로고    scopus 로고
    • Ischemia/reperfusion-induced death of cardiac myocytes: Possible involvement of nitric oxide in the coordination of ATP supply and demand during ischemia
    • doi: 10.1016/j.yjmcc.2005.06.020
    • Kawahara K, Hachiro T, Yokokawa T et al (2006) Ischemia/ reperfusion-induced death of cardiac myocytes: Possible involvement of nitric oxide in the coordination of ATP supply and demand during ischemia. J Mol Cell Cardiol 40(1):35-46. doi: 10.1016/ j.yjmcc.2005.06.020
    • (2006) J Mol Cell Cardiol , vol.40 , Issue.1 , pp. 35-46
    • Kawahara, K.1    Hachiro, T.2    Yokokawa, T.3
  • 42
    • 0037293568 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning
    • doi: 10.1038/sj.bjp.0705080
    • Ferdinandy P, Schulz R (2003) Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning. Br J Pharmacol 138:532-543. doi: 10.1038/sj.bjp.0705080
    • (2003) Br J Pharmacol , vol.138 , pp. 532-543
    • Ferdinandy, P.1    Schulz, R.2
  • 43
    • 0032923492 scopus 로고    scopus 로고
    • Non-enzymatic nitric oxide synthesis in biological systems
    • doi: 10.1016/S0005-2728(99)00018-3
    • Zweier JL, Samouilov A, Kuppusamy P (1999) Non-enzymatic nitric oxide synthesis in biological systems. Biochim Biophys Acta 1411:250-262. doi: 10.1016/S0005-2728(99)00018-3
    • (1999) Biochim Biophys Acta , vol.1411 , pp. 250-262
    • Zweier, J.L.1    Samouilov, A.2    Kuppusamy, P.3
  • 44
    • 0032496394 scopus 로고    scopus 로고
    • Xanthine oxidoreductase catalyzes the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions
    • doi: 10.1016/S0014-5793(98)00430-X
    • Millar TM, Stevens CR, Benjamin N et al (1998) Xanthine oxidoreductase catalyzes the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions. FEBS Lett 427:225-228. doi: 10.1016/ S0014-5793(98)00430-X
    • (1998) FEBS Lett , vol.427 , pp. 225-228
    • Millar, T.M.1    Stevens, C.R.2    Benjamin, N.3
  • 45
    • 20944446791 scopus 로고    scopus 로고
    • Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
    • Duranski MR, Greer JJ, Dejam A et al (2005) Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest 115:1232-1240
    • (2005) J Clin Invest , vol.115 , pp. 1232-1240
    • Duranski, M.R.1    Greer, J.J.2    Dejam, A.3
  • 46
    • 0036645303 scopus 로고    scopus 로고
    • Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase
    • doi: 10.1161/01.CIR.0000020682.73694.AB
    • Takemoto M, Sun J, Hiroki J et al (2002) Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation 106(1):57-62. doi: 10.1161/01.CIR.0000020682.73694.AB
    • (2002) Circulation , vol.106 , Issue.1 , pp. 57-62
    • Takemoto, M.1    Sun, J.2    Hiroki, J.3
  • 47
    • 0028847188 scopus 로고
    • Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells
    • Xu XP, Pollock JS, Tanner MA et al (1995) Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells. Cardiovasc Res 30(6):841-847
    • (1995) Cardiovasc Res , vol.30 , Issue.6 , pp. 841-847
    • Xu, X.P.1    Pollock, J.S.2    Tanner, M.A.3
  • 48
    • 0034737826 scopus 로고    scopus 로고
    • Downregulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vivo
    • Toporsian M, Govindaraju K, Nagi M et al (2000) Downregulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vivo. Circ Res 86(6):671-675
    • (2000) Circ Res , vol.86 , Issue.6 , pp. 671-675
    • Toporsian, M.1    Govindaraju, K.2    Nagi, M.3
  • 49
    • 0034803748 scopus 로고    scopus 로고
    • Intermittent hypoxia modulates nNOS expression and heart rate response to sympathetic nerve stimulation
    • Mohan RM, Golding S, Paterson DJ (2001) Intermittent hypoxia modulates nNOS expression and heart rate response to sympathetic nerve stimulation. Am J Physiol Heart Circ Physiol 281(1):H132-H138
    • (2001) Am J Physiol Heart Circ Physiol , vol.281 , Issue.1
    • Mohan, R.M.1    Golding, S.2    Paterson, D.J.3
  • 50
    • 0042917516 scopus 로고    scopus 로고
    • Nitric oxide and cardiac function: Ten years after, and continuing
    • doi: 10.1161/01.RES.0000088351.58510.21
    • Massion PB, Feron O, Dessy C et al (2003) Nitric oxide and cardiac function: Ten years after, and continuing. Circ Res 93:388-398. doi: 10.1161/01.RES.0000088351.58510.21
    • (2003) Circ Res , vol.93 , pp. 388-398
    • Massion, P.B.1    Feron, O.2    Dessy, C.3
  • 51
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • doi: 10.1038/21224
    • Dimmeler S, Fleming I, Fisslthaler B et al (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605. doi: 10.1038/21224
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3
  • 52
    • 33847018997 scopus 로고    scopus 로고
    • Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways
    • doi: 10.1161/01.HYP.0000251865.35728.2f
    • Sampaio WO, Dos Santos RAS, Faria-Silva R et al (2007) Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension 49:185-192. doi: 10.1161/01.HYP.0000251865.35728.2f
    • (2007) Hypertension , vol.49 , pp. 185-192
    • Sampaio, W.O.1    Dos Santos, R.A.S.2    Faria-Silva, R.3
  • 53
    • 18044403985 scopus 로고    scopus 로고
    • Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells
    • doi: 10.1074/jbc.M005036200
    • Hisamoto K, Ohmichi M, Kurachi H et al (2001) Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem 276(5):3459-3467. doi: 10.1074/ jbc.M005036200
    • (2001) J Biol Chem , vol.276 , Issue.5 , pp. 3459-3467
    • Hisamoto, K.1    Ohmichi, M.2    Kurachi, H.3


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