Examination of selected clinical factors and medication use as risk factors for pneumonia during stroke rehabilitation: A case-control study

American Journal of Physical Medicine and Rehabilitation

Volumn 88, Issue 1, 2009, Pages 30-38

  Marciniak, Christina ^a,b   Korutz, Alexander W ^a   Lin, Emily ^c   Roth, Elliot ^a,b   Welty, Leah ^a   Lovell, Linda ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b REHABILITATION INSTITUTE OF CHICAGO   (United States)

^c Department of Obstetrics Gynecology

Author keywords

ACE inhibitor; Cerebrovascular disorders; Pneumonia; Rehabilitation

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HISTAMINE H2 RECEPTOR ANTAGONIST; PROTON PUMP INHIBITOR; ANTIHYPERTENSIVE AGENT;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIET THERAPY; DYSPHAGIA; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL INDEPENDENCE MEASURE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PNEUMONIA; RISK ASSESSMENT; RISK FACTOR; STROKE; TRACHEOSTOMY; TUBE; UNIVARIATE ANALYSIS; CHEMICALLY INDUCED DISORDER; ENTERIC FEEDING; REHABILITATION CENTER; RISK; STATISTICAL MODEL;

AGED; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIHYPERTENSIVE AGENTS; CASE-CONTROL STUDIES; DEGLUTITION DISORDERS; ENTERAL NUTRITION; FEMALE; HISTAMINE H2 ANTAGONISTS; HUMANS; LOGISTIC MODELS; MALE; ODDS RATIO; PNEUMONIA; PROTON PUMP INHIBITORS; REHABILITATION CENTERS; RISK FACTORS; SEVERITY OF ILLNESS INDEX; STROKE; TRACHEOSTOMY;

EID: 58249093455     PISSN: 08949115     EISSN: None     Source Type: Journal    
DOI: 10.1097/PHM.0b013e3181909b73     Document Type: Article

References (53)

1. Davenport RJ, Dennis MS, Wellwood I, et al: Complications after acute stroke. Stroke 1996;27:415-20
2. Roth EJ, Lovell L, Harvey RL, et al: Incidence of and risk factors for medical complications during stroke rehabilitation. Stroke 2001;32:523-9
3. Kidd D, Lawson J, Nesbitt R, et al: The natural history and clinical consequences of aspiration in acute stroke. QJM 1995;88:409-13
4. Hilker R, Poetter C, Findeisen N, et al: Nosocomial pneumonia after acute stroke: Implications for neurological intensive care medicine. Stroke 2003;34: 975-81
5. Dziewas R, Ritter M, Schilling M, et al: Pneumonia in acute stroke patients fed by nasogastric tube. J Neurol Neurosurg Psychiatry 2004;75:852-6
6. Addington WR, Stephens RE, Gilliland KA: Assessing the laryngeal cough reflex and the risk of developing pneumonia after stroke: An interhospital comparison. Stroke 1999;30:1203-7
7. Nakajoh K, Nakagawa T, Sekizawa K, et al: Relation between incidence of pneumonia and protective reflexes in post-stroke patients with oral or tube feeding. J Intern Med 2000;247:39-42
8. Niimi A, Matsumoto H, Ueda T, et al: Impaired cough reflex in patients with recurrent pneumonia. Thorax 2003;58:152-3
9. Fox AJ, Lalloo UG, Belvisi MG, et al: Bradykininevoked sensitization of airway sensory nerves: A mechanism for ACE-inhibitor cough. Nat Med 1996; 2:814-7
10. Yamaya M, Yanai M, Ohrui T, et al: Interventions to prevent pneumonia among older adults. J Am Geriatr Soc 2001;49:85-90
11. Ohkubo T, Chapman N, Neal B, et al: Effects of an angiotensin-converting enzyme inhibitor-based regimen on pneumonia risk. Am J Respir Crit Care Med 2004;169:1041-5
12. Okaishi K, Morimoto S, Fukuo K, et al: Reduction of risk of pneumonia associated with use of angiotensin I converting enzyme inhibitors in elderly inpatients. Am J Hypertens 1999;12:778-83
13. Sekizawa K, Ujiie Y, Itabashi S, et al: Lack of cough reflex in aspiration pneumonia. Lancet 1990; 335: 1228-9
14. Huxley EJ, Viroslav J, Gray WR, et al: Pharyngeal aspiration in normal adults and patients with depressed consciousness. Am J Med 1978;64:564-8
15. Gleeson K, Eggli DF, Maxwell SL: Quantitative aspiration during sleep in normal subjects. Chest 1997; 111:1266-72
16. Simms HH, DeMaria E, McDonald L, et al: Role of gastric colonization in the development of pneumonia in critically ill trauma patients: Results of a prospective randomized trial. J Trauma 1991;31: 531-6; discussion 536-7
17. Laheij RJ, Sturkenboom MC, Hassing RJ, et al: Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. JAMA 2004;292:1955-60
18. Gulmez SE, Holm A, Frederiksen H, et al: Use of proton pump inhibitors and the risk of communityacquired pneumonia: A population-based case-control study. Arch Intern Med 2007;167:950-5
19. WHO: Stroke-1989. Recommendations on stroke prevention, diagnosis, and therapy: Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke 1989;20:1407-31
20. Cherney L, Pannell JJ, Cantieri CA: Management of dysphagia in adults and children, in Chereny L (ed): Clinical Evaluation of Dysphagia in Adults. Gaithersburg MD, Aspen Publishers, Inc., 1994, pp 49-69
21. Steefel J: Dysphagia Rehabilitation for Neurologically Impaired Adults. Springfield IL, Charles C Thomas, 1981
22. Hosmer DW, Lemeshow S: Applied Logistic Regression. New York, Wiley, 1989
23. James R, Gines D, Menlove A, et al: Nutrition support (tube feeding) as a rehabilitation intervention. Arch Phys Med Rehabil 2005;86:S82-92
24. Hamdy S, Rothwell JC, Aziz Q, et al: Organization and reorganization of human swallowing motor cortex: Implications for recovery after stroke. Clin Sci 2000;99:151-7
25. Harvey RL, Roth EJ, Heinemann AW, et al: Stroke rehabilitation: Clinical predictors of resource utilization. Arch Phys Med Rehabil 1998;79:1349-55
26. Roth EJ, Lovell L, Harvey RL, et al: Stroke rehabilitation: Indwelling urinary catheters, enteral feeding tubes, and tracheostomies are associated with resource use and functional outcomes. Stroke 2002;33:1845-50
27. Holas MA, DePippo KL, Reding MJ: Aspiration and relative risk of medical complications following stroke. Arch Neurol 1994;51:1051-3
28. Teasell RW, McRae M, Marchuk Y, et al: Pneumonia associated with aspiration following stroke. Arch Phys Med Rehabil 1996;77:707-9
29. Vilar J, Domingo ML, Soto C, et al: Radiology of bacterial pneumonia. Eur J Radiol 2004;51:102-13
30. Iizuka M, Reding M: Use of percutaneous endoscopic gastrostomy feeding tubes and functional recovery in stroke rehabilitation: A case-matched controlled study. Arch Phys Med Rehabil 2005;86:1049-52
31. Ding R, Logemann JA: Swallow physiology in patients with trach cuff inflated or deflated: A retrospective study. Head Neck 2005;27:809-13
32. Elpern EH, Scott MG, Petro L, et al: Pulmonary aspiration in mechanically ventilated patients with tracheostomies. Chest 1994;105:563-6
33. Leder SB, Espinosa JF: Aspiration risk after acute stroke: Comparison of clinical examination and fiberoptic endoscopic evaluation of swallowing [see comment]. Dysphagia 2002;17:214-8
34. Rabinstein AA, Wijdicks EF: Outcome of survivors of acute stroke who require prolonged ventilatory assistance and tracheostomy. Cerebrovasc Dis 2004; 18:325-31
35. Suiter DM, McCullough GH, Powell PW: Effects of cuff deflation and one-way tracheostomy speaking valve placement on swallow physiology. Dysphagia 2003;18:284-92
36. Thorens J, Froehlich F, Schwizer W, et al: Bacterial overgrowth during treatment with omeprazole compared with cimetidine: A prospective randomised double blind study. Gut 1996;39:54-9
37. Sanduleanu S, Jonkers D, De Bruine A, et al: Nonhelicobacter pylori bacterial flora during acid-suppressive therapy: Differential findings in gastric juice and gastric mucosa. Aliment Pharmacol Ther 2001; 15:379-88
38. Mikawa K, Akamatsu H, Nishina K, et al: The effects of cimetidine, ranitidine, and famotidine on human neutrophil functions. Anesth Analg 1999;89:218-24
39. Aybay C, Imir T, Okur H: The effect of omeprazole on human natural killer cell activity. Gen Pharmacol 1995;26:1413-8
40. Scaringi L, Cornacchione P, Fettucciari K, et al: Activity inhibition of cytolytic lymphocytes by omeprazole. Scand J Immunol 1996;44:204-14
41. Cook DJ, Walter SD, Cook RJ, et al: Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 1998;129: 433-40
42. Nardino RJ, Vender RJ, Herbert PN: Overuse of acidsuppressive therapy in hospitalized patients. Am J Gastroenterol 2000;95:3118-22
43. Naunton M, Peterson GM, Bleasel MD: Overuse of proton pump inhibitors. J Clin Pharm Ther 2000; 25:333-40
44. Scagliarini R, Magnani E, Pratico A, et al: Inadequate use of acid-suppressive therapy in hospitalized patients and its implications for general practice. Dig Dis Sci 2005;50:2307-11
45. Arai T, Yasuda Y, Takaya T, et al: ACE inhibitors and symptomless dysphagia. Lancet 1998;352:115-6
46. Wada H, Nakajoh K, Satoh-Nakagawa T, et al: Risk factors of aspiration pneumonia in Alzheimer's disease patients. Gerontology 2001;47:271-6
47. Arai T, Yasuda Y, Toshima S, et al: ACE inhibitors and pneumonia in elderly people. Lancet 1998;352: 1937-8
48. Arai T, Sekizawa K, Ohrui T, et al: ACE inhibitors and protection against pneumonia in elderly patients with stroke. Neurology 2005;64:573-4
49. Mortensen EM, Restrepo MI, Anzueto A, et al: The impact of prior outpatient ACE inhibitor use on 30-day mortality for patients hospitalized with community-acquired pneumonia. BMC Pulm Med 2005; 5:12
50. Takahashi T, Morimoto S, Okaishi K, et al: Reduction of pneumonia risk by an angiotensin I-converting enzyme inhibitor in elderly Japanese inpatients according to insertion/deletion polymorphism of the angiotensin I-converting enzyme gene. Am J Hypertens 2005;18:1353-9
51. Dennis M, Lewis S, Cranswick G, et al: FOOD: A multicentre randomised trial evaluating feeding policies in patients admitted to hospital with a recent stroke. Health Technol Assess 2006;10:iii-iv, ix-x, 1-120
52. Scolapio JS: Methods for decreasing risk of aspiration pneumonia in critically ill patients. JPEN J Parenter Enteral Nutr 2002;26:S58-61; discussion S61
53. Watando A, Ebihara S, Ebihara T, et al: Daily oral care and cough reflex sensitivity in elderly nursing home patients. Chest 2004;126:1066-70